A Prospective Cohort Study of COVID-19 Vaccination, SARS-CoV-2 Infection, and Fertility

American Journal of Epidemiology, Journal Year: 2022, Volume and Issue: 191(8), P. 1383 - 1395

Published: Jan. 14, 2022

Some reproductive-aged individuals remain unvaccinated against coronavirus disease 2019 (COVID-19) because of concerns about potential adverse effects on fertility. Using data from an internet-based preconception cohort study, we examined the associations COVID-19 vaccination and severe acute respiratory syndrome 2 (SARS-CoV-2) infection with fertility among couples trying to conceive spontaneously. We enrolled 2,126 self-identified female participants aged 21-45 year residing in United States or Canada during December 2020-September 2021 followed them through November 2021. Participants completed questionnaires every 8 weeks sociodemographics, lifestyle, medical factors, partner information. fit proportional probabilities regression models estimate between self-reported SARS-CoV-2 both partners fecundability (i.e., per-cycle probability conception), adjusting for confounders. was not appreciably associated either (female ratio (FR) = 1.08, 95% confidence interval (CI): 0.95, 1.23; male FR CI: 0.83, 1.10). Female strongly (FR 1.07, 0.87, 1.31). Male a transient reduction (for within 60 days, 0.82, 0.47, 1.45; after 1.16, 0.92, 1.47). These findings indicate that may be short-term decline does impair partner.

Language: Английский

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Male reproductive health after 3 months from SARS-CoV-2 infection: a multicentric study

Journal of Endocrinological Investigation, Journal Year: 2022, Volume and Issue: 46(1), P. 89 - 101

Published: Aug. 9, 2022

Abstract Purpose While SARS-CoV-2 infection appears not to be clinically evident in the testes, indirect inflammatory effects and fever may impair testicular function. To date, few long-term data of semen parameters impairment after recovery comprehensive andrological evaluation recovered patients has been published. The purpose this study was investigate whether affect male reproductive health. Methods Eighty were recruited three months COVID-19 recovery. They performed physical examination, ultrasound, analysis, sperm DNA integrity (TUNEL), anti-sperm antibodies (ASA) testing, sex hormone profile (Total testosterone, LH, FSH). In addition, all administered International Index Erectile Function questionnaire (IIEF-15). Sperm compared with two age-matched healthy pre-COVID-19 control groups normozoospermic (CTR1) primary infertile (CTR2) subjects. Results Median values from subjects within WHO 2010 fifth percentile. Mean percentage fragmentation (%SDF) 14.1 ± 7.0%. Gelatin Agglutination Test ( GAT ) positive 3.9% blood serum samples, but no plasma sample found. Only five (6.2%) had total testosterone levels below laboratory reference range. bilateral volume 31.5 9.6 ml. dysfunction detected 30% Conclusion Our remark that does seem cause direct damage function, while transient. It is possible counsel couples postpone research parenthood or ART procedures around infection.

Language: Английский

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Impact of COVID 19 on erectile function

The Aging Male, Journal Year: 2022, Volume and Issue: 25(1), P. 202 - 216

Published: Aug. 4, 2022

Purpose: COVID-19, a novel infection, presented with several complications, including socioeconomical and reproductive health challenges such as erectile dysfunction (ED). The present review summarizes the available shreds of evidence on impact COVID-19 ED.Materials methods: All published peer-reviewed articles from onset outbreak to date, relating ED, were reviewed. Results: Available pieces that ED is consequence are convincing. share common risk factors disruption vascular integrity, cardiovascular disease (CVD), cytokine storm, diabetes, obesity, chronic kidney (CKD). also induces impaired pulmonary haemodynamics, increased ang II, testicular damage low serum testosterone, reduced arginine-dependent NO bioavailability promotes reactive oxygen species (ROS) generation endothelial dysfunction, resulting in ED. In addition, triggers psychological/mental stress suppresses testosterone-dependent dopamine concentration, which contributes incident ED.Conclusions: conclusion, exerts detrimental effect male function, function. This involves cascade events multiple pathways. As pandemic dwindles, identifying long-term effects COVID-19-induced proffering adequate effective measures militating against remains pertinent.

Language: Английский

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Effects of SARS-CoV-2 Inflammation on Selected Organ Systems of the Human Body

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(8), P. 4178 - 4178

Published: April 10, 2022

SARS-CoV-2 virus does not only affect the respiratory system. It may cause damage to many organ systems with long-term effects. The latest scientific reports inform that this leaves a trace in nervous, circulatory, respiratory, urinary and reproductive systems. manifests itself disturbances functioning of organs these systems, causing serious health problems. aim study was review research into effects COVID-19 determine how common symptoms are who is most at risk. Based on literature using electronic databases PubMed Web Science infection, 88 studies were included analysis. information contained analyzed shows can multi-organ damage, number negative complications. There evidence complications lasting more than six months. They mainly concern circulatory However, small or short-lasting, speculative.

Language: Английский

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Erectile dysfunction and premature ejaculation: a continuum movens supporting couple sexual dysfunction

Journal of Endocrinological Investigation, Journal Year: 2022, Volume and Issue: 45(11), P. 2029 - 2041

Published: May 3, 2022

Language: Английский

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Metabolic syndrome and erectile dysfunction: a systematic review and meta-analysis study

Journal of Endocrinological Investigation, Journal Year: 2023, Volume and Issue: 46(11), P. 2195 - 2211

Published: July 29, 2023

Language: Английский

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Galectin-3 is involved in inflammation and fibrosis in arteriogenic erectile dysfunction via the TLR4/MyD88/NF-κB pathway

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Feb. 20, 2024

Abstract Galectin-3 (Gal-3) is a multifunctional protein that has been linked to fibrosis and inflammation in the cardiovascular system. In this study, we examined impact of Gal-3 on patients with arteriogenic erectile dysfunction (A-ED) underlying mechanisms involved. To induce arterial injury, utilized cuffs periaqueductal common iliac arteries Sprague‒Dawley (SD) rats administered high-fat diet co-induce local atherosclerosis. Our results showed successfully developed novel A-ED model was validated based histological evidence. vivo, vascular lumen subjected cuff placement exhibited significant narrowing, accompanied by upregulation Gal-3, Toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88) expression penile cavernosa. This led activation nuclear factor kappa B 65 (NF-κB-p65), resulting reduced intracavernosal pressure, endothelial nitric oxide synthase expression, smooth muscle content, promoting fibrosis. However, treatment inhibitor-modified citrus pectin (MCP) significantly normalized those effects. vitro, knocking down reduction TLR4, MyD88, NF-κB-p65 corpus cavernosum cells (CCSMCs), decreasing levels. conclusion, inhibiting may improve reducing inflammation, through TLR4/MyD88/NF-κB pathway. These findings highlight potential therapeutic target A-ED.

Language: Английский

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Prevalence and risk factors of erectile dysfunction in COVID-19 patients: a systematic review and meta-analysis

Journal of Endocrinological Investigation, Journal Year: 2022, Volume and Issue: 46(4), P. 795 - 804

Published: Oct. 28, 2022

Language: Английский

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COVID-19 vaccination does not affect male sexual functions

Reproductive Biology and Endocrinology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Jan. 13, 2023

COVID-19 infection has been linked with erectile dysfunction, which also raised apprehensions about the impact of vaccination on male sexual functions. The purpose this study was to investigate functions, such as function, orgasmic desire, intercourse satisfaction, and overall satisfaction.We used International Index Erectile Function (IIEF) questionnaire for data collection. Mixed methods were adopted study, consisted Google online form distribution hard copies those who not internet friendly. All entered in a spreadsheet scores assigned each response according standard given IIEF questionnaire. Fifteen questions, one corresponding question questionnaire, included assess function.In first part analysis, we calculated function men reporting low (~ 15%) excluded, providing us 465 individuals further analysis. Regarding 71% reported no impact, 3% decline, 2.7% an improvement, 23.3% could impact. We performed analysis basis age-groups participants duration after vaccination, finding that there irrespective age subjects or length period vaccination.COVID-19 does affect including satisfaction.

Language: Английский

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A systematic review on the correlation between COVID-19 and lower urinary tract symptoms

Journal of Clinical Virology Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100202 - 100202

Published: Jan. 1, 2025

Language: Английский

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