Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: April 6, 2022

Abstract Natural enzymes usually suffer from high production cost, ease of denaturation and inactivation, low yield, making them difficult to be broadly applicable. As an emerging type artificial enzyme, nanozymes that combine the characteristics nanomaterials are promising alternatives. On one hand, have enzyme-like catalytic activities regulate biochemical reactions. other also inherit properties nanomaterials, which can ameliorate shortcomings natural serve as versatile platforms for diverse applications. In this review, various mimic activity different introduced. The achievements in cancer diagnosis treatment technologies summarized by highlighting advantages these Finally, future research directions rapidly developing field outlooked."Image missing"

Language: Английский

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MOF-818 nanozyme-based colorimetric and electrochemical dual-mode smartphone sensing platform for in situ detection of H2O2 and H2S released from living cells

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 451, P. 138321 - 138321

Published: Aug. 1, 2022

Language: Английский

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Single‐Atomic Iron Doped Carbon Dots with Both Photoluminescence and Oxidase‐Like Activity

Small, Journal Year: 2022, Volume and Issue: 18(37)

Published: Aug. 19, 2022

Abstract Multifunctional nanozymes can benefit biochemical analysis via expanding sensing modes and enhancing analytical performance, but designing multifunctional to realize the desired of targets is challenging. In this work, single‐atomic iron doped carbon dots (SA Fe‐CDs) are designed synthesized a facile in situ pyrolysis process. The small‐sized CDs not only maintain their tunable fluorescence, also serve as support for loading dispersed active sites. Monoatomic Fe offers SA Fe‐CDs exceptional oxidase‐mimetic activity catalyze 3,3′,5,5′‐tetramethylbenzidine (TMB) oxidation with fast response ( V max = 10.4 nM s ‐1 ) strong affinity K m 168 µM). Meanwhile, photoluminescence quenched by product TMB due inner filter effect. Phosphate ions (Pi) suppress oxidase‐mimicking restore interacting Based on principle, dual‐mode colorimetric fluorescence assay Pi high sensitivity, selectivity, rapid established. This work paves path develop enzyme‐like catalysts, simple efficient method phosphate monitoring, which will inspire exploration multi‐mode strategies based nanozyme catalysis.

Language: Английский

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A versatile platform for colorimetric, fluorescence and photothermal multi-mode glyphosate sensing by carbon dots anchoring ferrocene metal-organic framework nanosheet

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 443, P. 130277 - 130277

Published: Oct. 30, 2022

Language: Английский

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Biomedical Applications of Microfluidic Devices: A Review

Biosensors, Journal Year: 2022, Volume and Issue: 12(11), P. 1023 - 1023

Published: Nov. 16, 2022

Both passive and active microfluidic chips are used in many biomedical chemical applications to support fluid mixing, particle manipulations, signal detection. Passive devices geometry-dependent, their uses rather limited. Active include sensors or detectors that transduce chemical, biological, physical changes into electrical optical signals. Also, they transduction detect biological applications, highly versatile tools for disease diagnosis organ modeling. This review provides a comprehensive overview of the significant advances have been made development microfluidics devices. We will discuss function as micromixers sorters cells substances (e.g., microfiltration, flow displacement, trapping). Microfluidic fabricated using range techniques, including molding, etching, three-dimensional printing, nanofabrication. Their broad utility lies detection diagnostic biomarkers organ-on-chip approaches permit modeling cancer, well neurological, cardiovascular, hepatic, pulmonary diseases. Biosensor allow point-of-care testing, assays based on enzymes, nanozymes, antibodies, nucleic acids (DNA RNA). An anticipated field includes optimization techniques fabrication biocompatible materials. These developments increase versatility, reduce costs, accelerate time technology.

Language: Английский

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Microenvironment‐Activated Nanozyme‐Armed Bacteriophages Efficiently Combat Bacterial Infection

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(30)

Published: April 21, 2023

Bacterial infection is one of the greatest challenges to public health, requiring new therapeutic methods. Herein, an innovative nanozyme-armed phage (phage@palladium (Pd)) system fabricated for combating bacterial infection. The proposed phage@Pd preserves function phages achieve precise recognition and adhesion host Escherichia coli. In aid phages, ultrasmall Pd nanozymes equipped with conspicuous pH-dependent peroxidase-like activity can generate toxic hydroxyl radical around bacteria in acidic hydrogen-peroxide-overexpressed microenvironment while remaining inert physiological conditions, thus realizing noteworthy elimination at infected sites, meantime ensuring biological safety healthy tissues. addition, filamentous structure also enhance its bactericidal efficiency toward nonhost by randomly entangling on them, indicating possible broad-spectrum germicidal efficacy. Notably, not only eradicate planktonic bacteria, but kill inside biofilm vitro. For both vivo models acute pneumonia or subcutaneous abscess, shows significant eliminating promoting tissue recovery. These results demonstrate that nanohybrid a safe effective antimicrobial agent, providing insight into development advanced antibacterial materials.

Language: Английский

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The Nanozyme Revolution: Enhancing the Performance of Medical Biosensing Platforms

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: April 27, 2023

Nanozymes represent a class of nanosized materials that exhibit innate catalytic properties similar to biological enzymes. The unique features these have positioned them as promising candidates for applications in clinical sensing devices, specifically those employed at the point-of-care. They notably found use means amplify signals nanosensor-based platforms and thereby improve sensor detection limits. Recent developments understanding fundamental chemistries underpinning enabled development highly effective nanozymes capable clinically relevant biomarkers limits compete with "gold-standard" techniques. However, there remain considerable hurdles need be overcome before nanozyme-based sensors can utilized platform ready use. An overview current understandings disease diagnostics biosensing unmet challenges must considered prior their translation diagnostic tests is provided.

Language: Английский

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Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Biosensors, Journal Year: 2023, Volume and Issue: 13(4), P. 461 - 461

Published: April 5, 2023

This review highlights the recent advancements in field of nanozymes and their applications development point-of-care biosensors. The use as enzyme-mimicking components biosensing systems has led to improved performance miniaturization these sensors. unique properties nanozymes, such high stability, robustness, surface tunability, make them an attractive alternative traditional enzymes applications. Researchers have explored a wide range nanomaterials, including metals, metal oxides, metal–organic frameworks, for nanozyme-based Different sensing strategies, colorimetric, fluorescent, electrochemical SERS, been implemented using signal-producing components. Despite numerous advantages, there are also challenges associated with biosensors, stability specificity, which need be addressed wider future biosensors looks promising, potential bring paradigm shift biomolecular sensing. highly specific, multi-enzyme mimicking could lead creation sensitive low-biofouling Integration into diagnostics promises revolutionize healthcare by improving patient outcomes reducing costs while enhancing accuracy sensitivity diagnostic tools.

Language: Английский

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Bioinspired and Green Synthesis of Silver Nanoparticles for Medical Applications: A Green Perspective

Applied Biochemistry and Biotechnology, Journal Year: 2023, Volume and Issue: 196(6), P. 3636 - 3669

Published: Sept. 5, 2023

Silver nanoparticles (AgNPs) possess unmatched chemical, biological, and physical properties that make them unique compounds as antimicrobial, antifungal, antiviral, anticancer agents. With the increasing drug resistance, AgNPs serve promising entities for targeted therapy against several bacterial, fungal, viral components. In addition, also successful agents cancers, including breast, prostate, lung cancers. Several works in recent years have been done towards development of by using plant extracts like flowers, leaves, bark, root, stem, whole parts. The green method AgNP synthesis thus has advantages over chemical methods, especially low cost synthesis, no toxic byproducts, eco-friendly production pathways, can be easily regenerated, bio-reducing potential derived nanoparticles. Furthermore, are biocompatible do not harm normally functioning human or host cells. This review provides an exhaustive overview synthesized used After a brief introduction, we discussed studies on from different extracts, leaf parts, seeds, stems, plants. following section, highlighted therapeutic actions various bacteria, fungi, viruses, We then general mechanism action AgNPs. methods were article. Finally, concluded providing future perspectives this field nanotechnology.

Language: Английский

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Challenges of Emerging Wearable Sensors for Remote Monitoring toward Telemedicine Healthcare

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(3), P. 1773 - 1784

Published: Jan. 11, 2023

Digitized telemedicine tools with the Internet of Things (IoT) started advancing into our daily lives and have been incorporated commercial wearable gadgets for noninvasive remote health monitoring. The newly established steered toward a new era decentralized healthcare. advancement monitoring system has attracted enormous interest in multimodal big data acquisition real-time physiological biochemical information via methods any health-related industries. expectation creation focused on early diagnosis multiple diseases minimizing cost high-tech invasive treatments. However, only limited progress directed development sensors. This Perspective addresses these sensors that encounter challenges forefront technological gaps hampering realization at molecular levels related to smart materials mostly single use, issues selectivity analytes, low sensitivity targets, miniaturization, lack artificial intelligence perform tasks secure transfer. Sensor stability minimized signal drift, on-body sensor reusability, long-term continuous provides key analytical challenges. also focuses on, promotes, highlights distinct capability interconnect healthcare physical sensing multiplex deeper levels. Moreover, it points out some critical different material aspects promotes what will take advance current state-of-art Ultimately, this is draw attention potential blind spots technology inspire further integrated mitigating multimorbidity aging societies through identify signs diseases.

Language: Английский

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