Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(39)
Published: July 15, 2024
Abstract
Growing
demand
for
wound
care
resulting
from
the
increasing
chronic
diseases
and
trauma
brings
intense
pressure
to
global
medical
health
service
system.
Artificial
skin
provides
mechanical
microenvironmental
support
wound,
which
is
crucial
in
healing
tissue
regeneration.
However,
challenges
still
remain
clinical
application
of
artificial
since
lack
synergy
effect
necessary
performance.
In
this
study,
a
multi‐functional
fabricated
through
microfluidic
spinning
technology
by
using
core‐shell
gel
nanofiber
scaffolds
(NFSs).
This
strategy
can
precisely
manipulate
microstructure
under
microscale.
The
as‐prepared
demonstrates
superior
characteristics
including
surface
wettability,
breathability,
high
strength,
strain
sensitivity,
biocompatibility
biodegradability.
Notably,
has
capability
deliver
medications
controlled
sustained
manner,
thereby
accelerating
process.
innovative
approach
paves
way
development
new
generation
introduces
novel
concept
structural
design
unique
NFSs.
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: April 30, 2024
Post-traumatic
peritendinous
adhesion
presents
a
significant
challenge
in
clinical
medicine.
This
study
proposes
the
use
of
diamond-like
carbon
(DLC)
deposited
on
polylactic
acid
(PLA)
membranes
as
biophysical
mechanism
for
anti-adhesion
barrier
to
encase
ruptured
tendons
tendon-injured
rats.
The
results
indicate
that
PLA/DLC
composite
membrane
exhibits
more
efficient
effect
than
PLA
membrane,
with
histological
score
decreasing
from
3.12
±
0.27
2.20
0.22
and
effectiveness
increasing
21.61%
44.72%.
Mechanistically,
abundant
C=O
bond
functional
groups
surface
DLC
can
reduce
reactive
oxygen
species
level
effectively;
thus,
phosphorylation
NF-κB
M1
polarization
macrophages
are
inhibited.
Consequently,
excessive
inflammatory
response
augmented
by
macrophage-originated
cytokines
including
interleukin-6
(IL-6),
interleukin-1β
(IL-1β),
tumor
necrosis
factor-α
(TNF-α)
is
largely
reduced.
For
biocompatibility
evaluation,
slowly
absorbed
within
tissue
displays
prolonged
effects
compared
traditional
membranes.
Further
studies
show
depositing
decelerates
release
degradation
product
lactic
its
induction
macrophage
M2
interfering
esterase
ester
bonds,
which
further
delays
fibrosis
process.
It
was
found
possess
an
treatment
adhesion.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(26), P. 32887 - 32905
Published: June 21, 2024
Hydrogel
bioelectronics
has
been
widely
used
in
wearable
sensors,
electronic
skin,
human-machine
interfaces,
and
implantable
tissue-electrode
providing
great
convenience
for
human
health,
safety,
education.
The
generation
of
waste
from
bioelectronic
devices
jeopardizes
health
the
natural
environment.
development
degradable
recyclable
hydrogels
is
recognized
as
a
paradigm
realizing
next
environmentally
friendly
sustainable
bioelectronics.
This
review
first
summarizes
wide
range
applications
bioelectronics,
including
devices.
Then,
employment
synthetic
polymers
hydrogel
discussed
terms
degradability
recyclability.
Finally,
this
work
provides
constructive
thoughts
perspectives
on
current
challenges
toward
valuable
insights
guidance
future
evolution