Galloylated Toll-Like Receptor 7/8 Agonist Nanovaccine for Enhanced Tumor Antigen Delivery in Personalized Immunotherapy DOI
Mengyao Ma,

Ximu Li,

Mingyuan Zhong

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Cancer vaccines, a critical technology in cancer immunotherapy, have shown great therapeutic potential. However, traditional vaccines based on tumor cell lysates (TCLs) disappointing results early clinical trials due to low immunogenicity, vivo instability, and the inability codeliver with adjuvants. To address these issues, we developed nanoparticle vaccine, R848-GA@TCLs, by modifying toll-like receptor 7/8 (TLR7/8) agonist R848 gallic acid. This nanovaccine leverages "capturing" ability of galloyl moiety coload TCLs R848, forming stable nanoparticles. R848-GA@TCLs efficiently target lymph nodes, increasing TCL accumulation 10-fold, enable synchronized release antigens adjuvants within dendritic cells (DCs). Our show that increase respect cross-presentation antigens, promote production pro-inflammatory cytokines, activate DCs, leading significant effector T cells, natural killer (NK) M1 macrophages. strong immune response resulted potent antitumor effects, demonstrating efficacy multiple models significantly inhibiting growth metastasis. In conclusion, represent personalized vaccine capable codelivering adjuvants, eliciting robust responses, hold potential for applications.

Language: Английский

The interplay between PEGylated nanoparticles and blood immune system DOI
Guo Chen, Haoyang Yuan,

Yuxiu Wang

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 115044 - 115044

Published: Aug. 2, 2023

Language: Английский

Citations

42
Cancer Nanovaccines: Nanomaterials and Clinical Perspectives DOI
Nimeet Desai, Vivek P. Chavda, Thakur Raghu Raj Singh

et al.

Small, Journal Year: 2024, Volume and Issue: 20(35)

Published: May 1, 2024

Abstract Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art nanovaccine development, elucidating innovative strategies and technologies employed their design. It explores both preclinical clinical advancements, emphasizing key studies demonstrating potential elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, impact of nanoscale properties on performance. Detailed insights into complex interplay between tumor microenvironment responses are provided, highlighting challenges opportunities optimizing therapeutic outcomes. Additionally, presents thorough analysis ongoing trials, presenting snapshot landscape. By curating latest scientific findings developments, this aims serve as comprehensive resource researchers clinicians engaged advancing immunotherapy. Integrating design holds immense promise revolutionizing treatment paradigms, provides timely update evolving landscape nanovaccines.

Language: Английский

Citations

24
A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-II Photo-Immunotherapy of Metastatic Tumor DOI Creative Commons

Yijian Gao,

Ying Liu, Xiliang Li

et al.

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 16(1)

Published: Nov. 20, 2023

Massive efforts have been concentrated on the advance of eminent near-infrared (NIR) photothermal materials (PTMs) in NIR-II window (1000-1700 nm), especially organic PTMs because their intrinsic biological safety compared with inorganic PTMs. However, so far, only a few NIR-II-responsive was explored, and conversion efficiencies (PCEs) still remain relatively low. Herein, donor-acceptor conjugated diradical polymers open-shell characteristics are explored for synergistically immunotherapy metastatic tumors window. By employing side-chain regulation, polymer TTB-2 obvious absorption developed, its nanoparticles realize record-breaking PCE 87.7% upon light illustration. In vitro vivo experiments demonstrate that show good tumor photoablation navigation photoacoustic imaging window, without any side-effect. Moreover, by combining PD-1 antibody, pulmonary metastasis breast cancer is high-effectively prevented efficient photo-immunity effect. Thus, this study explores superior theranostics offering new horizon developing radical-characteristic materials.

Language: Английский

Citations

36
Nanoparticle-based immunoengineering strategies for enhancing cancer immunotherapy DOI

Bao-Toan Nguyen Dang,

Taeg Kyu Kwon, Sooyeun Lee

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 365, P. 773 - 800

Published: Dec. 14, 2023

Language: Английский

Citations

24
Seizing the fate of lymph nodes in immunotherapy: To preserve or not? DOI
Zhenyu Xu, Zi‐Zhan Li, Lei‐Ming Cao

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216740 - 216740

Published: Feb. 27, 2024

Language: Английский

Citations

13
Lymphoid organ-targeted nanomaterials for immunomodulation of cancer, inflammation, and beyond DOI
Jessica C. Hsu, Peng Liu, Yangmeihui Song

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(15), P. 7657 - 7680

Published: Jan. 1, 2024

Nanomaterials exhibit significant potential for stimulating immune responses, offering both local and systemic modulation across a variety of diseases. The lymphoid organs, such as the spleen lymph nodes, are home to various cells, including monocytes dendritic which contribute progression prevention/treatment Consequently, many nanomaterial formulations being rationally designed target these organs engage with specific cell types, thereby inducing therapeutic protective effects. In this review, we explore crucial cellular interactions processes involved in regulation highlight innovative nano-based immunomodulatory approaches. We outline essential considerations design an emphasis on their impact biological interactions, targeting capabilities, treatment efficacy. Through selected examples, illustrate strategic therapeutically active nanomaterials subsequent immunomodulation infection resistance, inflammation suppression, self-antigen tolerance, cancer immunotherapy. Additionally, address current challenges, discuss emerging topics, share our outlook future developments field.

Language: Английский

Citations

11
Amyloid-β-targeting immunotherapies for Alzheimer's disease DOI
Yi Jin,

Qiaofei Du,

Mingjie Song

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 346 - 365

Published: Sept. 18, 2024

Language: Английский

Citations

9
Exploring the immuno-nano nexus: A paradigm shift in tumor vaccines DOI Open Access
Yuanyuan Li, Yuxing Xu,

Wenwen Su

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117897 - 117897

Published: Feb. 7, 2025

Language: Английский

Citations

1
A Spatially Distributed Microneedle System for Bioorthogonal T Cell‐Guided Cancer Therapy DOI Creative Commons

Lanya Li,

Fei Wang, Shushan Mo

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Chimeric antigen receptor (CAR)-T cell therapy represents a promising strategy for cancer treatment. However, the diversity of solid tumor antigens and poor infiltration CAR-T cells significantly hinder efficacy therapies against tumors. Here, spatially distributed microneedle system (SDMNS) is developed that leverages bioorthogonal reactions to activate guide endogenous T tumors effective destruction. The SDMNS consists two dissolving microneedles, each loaded with complementary groups applied separately lymph nodes sites. One dibenzocyclooctyne (DBCO)-modified antibodies activates labels them in nodes. other microneedle, containing N-azidoacetylmannosamine-tetraacylated (Ac4ManNAz) glycometabolic labeling cells, chemotactic factor IP10, directly site. vivo studies demonstrate effectively directs migration activated into Through click reaction, DBCO-modified conjugate azide (N3)-modified eliciting robust antitumor immune responses durable memory. offers novel overcomes heterogeneity by facilitating directed cells.

Language: Английский

Citations

1
Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment DOI Creative Commons
Mengyao Yang, Xin Wang,

Mengke Peng

et al.

Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 24, 2025

Abstract Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has advantages including high precision, non-invasiveness, minimal side effects, but also overcomes limitation of low penetration light to deep tumors. The cytotoxic reactive oxygen species be produced by utilization combined with US kill tumor cells. However, underlying mechanism been elucidated, its unsatisfactory efficiency retards further clinical application. Herein, we shed on main mechanisms types sonosensitizers, organic inorganic sonosensitizers. Due development nanotechnology, many novel nanoplatforms are utilized this arisen field solve barriers enable continuous innovation. This review highlights potential nanosonosensitizers focus enhanced based monotherapy or synergistic that difficult reach traditional treatment, especially orthotopic cancers.

Language: Английский

Citations

1