CuS/Co-Ferrocene-MOF Nanocomposites for Photothermally Enhanced Chemodynamic Antibacterial Therapy

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 10998 - 11007

Published: April 29, 2024

Infections caused by bacteria pose a serious threat to public health, and there is need for numerous innovative, antibiotic-free antimicrobial medicines. Herein, we describe the synthesis of CuS/Co-ferrocene-MOF (CuS/Co-Fc-MOF) nanocomposites, formed coupling CuS nanoparticles (NPs) two-dimensional (2D) Co-Fc-MOF nanosheets, that constitutes an platform capable near-infrared (NIR) photothermal promotion chemodynamic antibacterial. 2D CuS/Co-Fc-MOF nanocomposites consist nanosheets with dimensions approximately 100–200 nm thicknesses 13.1–15.6 nm, where NPs, size about 8 are excellently dispersed on surface nanosheets. The diverse valence states cobalt iron in enable them undergo Fenton-like reactions H2O2, thus generating highly oxidizing ·OH therapy (CDT). utilization local plasmonic resonance effect NPs enables enhancement CDT activity under laser irradiation. More importantly, can achieve rapid (15 min) NIR laser-assisted killing both S. aureus E. coli bacterial infection microenvironment compared Therefore, be employed as promising nanoagent promote photothermally augmented antibacterial therapy.

Language: Английский

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Single-Atom-Based Nanoenzyme in Tissue Repair

ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 12639 - 12671

Published: May 8, 2024

Since the discovery of ferromagnetic nanoparticles Fe3O4 that exhibit enzyme-like activity in 2007, research on nanoenzymes has made significant progress. With in-depth study various and rapid development related nanotechnology, have emerged as a promising alternative to natural enzymes. Within nanozymes, there is category metal-based single-atom nanozymes been rapidly developed due low cast, convenient preparation, long storage, less immunogenicity, especially higher efficiency. More importantly, possess capacity scavenge reactive oxygen species through mechanisms, which beneficial tissue repair process. Herein, this paper systemically highlights types metal their catalytic recent applications repair. The existing challenges are identified prospects future composed metallic nanomaterials proposed. We hope review will illuminate potential repair, encouraging sequential clinical translation.

Language: Английский

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Dual-ROS-scavenging and dual-lingering nanozyme-based eye drops alleviate dry eye disease

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 8, 2024

Abstract Efficiently removing excess reactive oxygen species (ROS) generated by various factors on the ocular surface is a promising strategy for preventing development of dry eye disease (DED). The currently available drops DED treatment are palliative, short-lived and frequently administered due to short precorneal residence time. Here, we developed nanozyme-based exploiting borate-mediated dynamic covalent complexation between n-FeZIF-8 nanozymes (n-Z(Fe)) poly(vinyl alcohol) (PVA) overcome these problems. resultant formulation (PBnZ), which has dual-ROS scavenging abilities prolonged corneal retention can effectively reduce oxidative stress, thereby providing an excellent preventive effect alleviate DED. In vitro in vivo experiments revealed that PBnZ could eliminate ROS through both its multienzyme-like activity ROS-scavenging borate bonds. positively charged displayed longer time physical adhesion bonds phenyboronic acid PVA or o-diol with mucin. results showed These dual-function provide insights into novel strategies other ROS-mediated inflammatory diseases rationale application nanomaterials clinical settings. Graphical

Language: Английский

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Microorganism microneedle micro-engine depth drug delivery

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 17, 2024

As a transdermal drug delivery method, microneedles offer minimal invasiveness, painlessness, and precise in-situ treatment. However, current rely on passive diffusion, leading to uncontrollable penetration. To overcome this, we developed pneumatic microneedle patch that uses live Enterobacter aerogenes as microengines actively control delivery. These microbes generate gas, driving drugs into deeper tissues, with adjustable glucose concentration allowing over the process. Our results showed this microorganism-powered system increases depth by 200%, reaching up 1000 μm below skin. In psoriasis animal model, technology effectively delivered calcitriol subcutaneous offering rapid symptom relief. This innovation addresses limitations of conventional microneedles, enhancing efficiency, permeability, introducing creative paradigm for on-demand controlled

Language: Английский

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Iron‐doped nanozymes with spontaneous peroxidase‐mimic activity as a promising antibacterial therapy for bacterial keratitis

Smart Medicine, Journal Year: 2024, Volume and Issue: 3(2)

Published: May 22, 2024

The development of non-antibiotic pharmaceuticals with biocompatible and efficient antibacterial properties is great significance for the treatment bacterial keratitis. In this study, we have developed iron-doped nanozymes (Fe

Language: Английский

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Tuning Atomically Dispersed Metal Sites in Nanozymes for Sensing Applications

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Abstract Nanozymes with atomically dispersed metal sites (ADzymes), especially single‐atom nanozymes, have attracted widespread attention in recent years due to their unique advantages mimicking the active of natural enzymes. These nanozymes not only maximize exposure catalytic but also possess superior activity performance, achieving challenging reactions. position ADzymes as highly promising candidates field sensing and biosensing. This review summarizes classification properties ADzymes, systematically highlighting some typical regulation strategies involving central metal, coordination environment, etc., achieve catalytical activity, specificity, multifunctionality. Then, we present advances different fields, including colorimetry, fluorescence, electrochemistry, chemiluminescence, photoelectrochemistry, electrochemiluminescence. Taking advantage resultant show great potential goal sensitivity, selectivity accuracy for detection various targets. Specifically, underlying mechanisms terms signal amplification were discussed detail. Finally, current challenges perspectives on development advanced are discussed.

Language: Английский

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Recent Advances in Nanotechnology for the Treatment of Dry Eye Disease

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(8), P. 669 - 669

Published: April 12, 2024

Dry eye disease (DED) incidence is continuously growing, positioning it to become an emergent health issue over the next few years. Several topical treatments are commonly used treat DED; however, reports indicate that only a minor proportion of drug bioavailability achieved by majority drops available on market. In this context, enhancing ability overcome ocular barriers and prolonging its residence time surface represent new challenge in field carrier systems. Therefore, research has focused development multi-functional nanosystems, such as nanoemulsions, liposomes, dendrimers, hydrogels, other nanosized carriers. These systems designed improve efficacy and, at same time, require fewer daily administrations, with potentially reduced side effects. This review summarizes different nanotechnologies developed, their role DED, nanotechnology-based eyedrops currently approved for DED treatment.

Language: Английский

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Rosmarinic acid-grafted gelatin nanogels for efficient diquafosol delivery in dry eye disease therapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 306 - 318

Published: July 19, 2024

Language: Английский

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Fluorinated multifunctional polymer vesicles for enhanced ocular surface penetration and synergistic treatment of dry eye disease

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 592 - 608

Published: Jan. 24, 2025

Language: Английский

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Ferrous Tungstate Nanomaterials with Excellent Enzyme-Mimicking Activity to Enhance Lateral Flow Immunoassay Sensitivity

Analytical Chemistry, Journal Year: 2025, Volume and Issue: 97(5), P. 2714 - 2723

Published: Jan. 30, 2025

Lateral flow immunochromatography (LFIA) with gold nanoparticles (AuNPs) is widely used in the biomedical field as a rapid and simple vitro detection technique. However, conventional AuNP-LFIA has limitations sensitivity range. In this study, nonprecious metal iron-based bimetallic FeWO4 nanomaterials convenient excellent enzyme-mimetic catalytic activities were synthesized by one-pot hydrothermal method. Here, combined C-reactive protein (CRP) antibodies to form novel signal-enhancing probe for analysis of CRP. The further achieves significant signal amplification catalyzing oxidation reaction 3-amino-9-ethylcarbazole LFIA assay, thereby improving accuracy assay. application FeWO4-based improved limit CRP 19.38 ng/mL after amplification, which approximately 30-fold lower than that addition, method demonstrated good stability reproducibility, providing promising prospective strategy early diagnosis inflammatory diseases.

Language: Английский

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