Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(42), P. 16676 - 16685
Published: Oct. 11, 2024
Wearable
sensors
enable
the
noninvasive
continuous
analysis
of
biofluid,
which
is
great
importance
for
healthcare
monitoring.
In
this
work,
a
wearable
sensor
was
seamlessly
integrated
with
microfluidic
chip
prepared
by
three-dimensional
printing
technology
and
multiplexed
metabolite
electrolytes
in
human
sweat.
The
could
rapid
sampling
sweat,
avoids
sweat
evaporation
contamination.
Using
Zn
metal–organic
framework
as
sacrificial
template,
hexagonal
rod-shaped
porous
carbon
nanorod
(PCN)
high
porosity,
large
specific
surface
area,
excellent
conductivity
synthesized
exhibited
robust
electrocatalytic
ability
uric
acid
(UA)
oxidation.
Therefore,
PCN-based
showed
sensitivity
good
selectivity
UA
wide
linear
range
10–200
μM
low
detection
limit
4.13
μM.
Meanwhile,
potentiometry-based
ion-selective
electrode
constructed
pH
K+,
respectively,
sensitivity,
selectivity,
reproducibility,
stability.
addition,
testing
under
different
bending
states
demonstrated
that
mechanical
deformation
had
little
effect
on
electrochemical
performance
sensors.
Furthermore,
we
evaluated
utility
real-time
UA,
pH,
K+
during
aerobic
exercise,
amount
consumed
purine-rich
foods
levels
urine
further
investigated.
relationship
between
obtained.
Overall,
enables
multiple
electrolyte
biofluids,
suggesting
its
potential
application
personalized
disease
prevention.
TrAC Trends in Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
172, P. 117596 - 117596
Published: Feb. 8, 2024
Diagnostic
devices
used
in
the
point-of-care
(POC)
today
play
a
critical
role
as
tools
to
provide
essential
medical
surveillance
data
and
ensure
that
patients
receive
appropriate
timely
care.
These
also
allow
self-analysis
by
patient,
increasing
therapeutic
adherence
well
reducing
pressure
on
clinical
structures.
The
development
of
new
diagnostic
tools,
therefore,
represents
significant
challenge
from
technological
point
view,
both
terms
overcoming
current
weaknesses
costs,
accuracy,
performance,
an
analytical
view
order
develop
are
operator-independent
possible.
Recent
breakthroughs
technologies
(such
cell
phone-dependent
technologies,
paper-based
procedures,
lab-on-a-chip
devices)
paving
way
for
next
generation
testing
(POCT).
Innovative
assay
devices,
efficient
reagent
storage
techniques,
required
POCT
technologies.
Nanomaterials
different
forms,
sizes,
compositions,
such
carbon
nanomaterials,
quantum
dots,
gold
silver
nanoparticles,
mesoporous
silica
metal-organic
frameworks
(MOFs),
have
been
created
characterized
recent
years.
Due
their
specific
physicochemical
properties,
MOF
nanoparticles
increasingly
being
improve
performance
simplify
techniques.
MOFs
colorimetric
or
electrochemical
carriers
plasmonic
biosensors
be
resistant
environmental
conditions.
This
review
will
discuss
detailed
2016
2023,
addition
chemical
synthesis
characterization
methods
related
uses
applications
MOF.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(10), P. 4224 - 4231
Published: Feb. 29, 2024
The
detection
of
physiological
phosphates
(PPs)
is
great
importance
due
to
their
essential
roles
in
numerous
biological
processes,
but
the
efficient
different
PPs
simultaneously
remains
challenging.
In
this
work,
we
propose
a
fluorescence
sensor
array
for
detecting
based
on
metal-ion-regulated
gold
nanoclusters
(AuNCs)
via
an
indicator-displacement
assay.
Zn2+
and
Eu3+
are
selected
assemble
with
two
AuNCs,
resulting
quenching
or
enhancing
fluorescence.
Based
competitive
interaction
metal
ions
AuNCs
PPs,
will
be
recovered
owing
disassembly
AuNC-metal
ion
ensembles.
Depending
PPs'
distinct
responses,
four-channel
was
established.
not
only
exhibits
good
discrimination
capability
eight
kinds
(i.e.,
ATP,
ADP,
AMP,
GTP,
CTP,
UTP,
PPi,
Pi)
linear
discriminant
analysis
also
enables
quantitative
single
phosphate
(e.g.,
ATP)
presence
interfering
mixtures.
Moreover,
potential
application
present
real
samples
cell
lysates
serum)
successfully
demonstrated
performance.
This
work
illustrates
ion-regulated
as
new
sensing
platform
differential
well
other
disease-related
biomolecules.
Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
95(32), P. 12104 - 12112
Published: Aug. 1, 2023
Adenosine
triphosphate
(ATP)
participates
in
the
regulation
of
most
biological
processes,
and
ATP
level
is
closely
associated
with
many
diseases.
However,
it
still
remains
challenging
to
achieve
on-site
monitoring
an
equipment-free
efficient
way.
Microneedles,
a
minimally
invasive
technology
that
can
extract
biomarkers
from
liquid
biopsies,
have
recently
emerged
as
useful
tools
for
early
diagnosis
broad
range
In
this
work,
we
developed
hydrogel
microneedles
are
loaded
ATP-specific
dual-emitting
gold
nanoclusters
(RhE-AuNCs)
fast
sampling
on-needle
detection
ATP.
These
RhE-AuNCs
were
photo-crosslinked
matrix
form
fluorescent
microneedle
patch.
Based
on
ATP-induced
Förster
resonance
energy
transfer
RhE-AuNCs,
highly
selective,
sensitive,
reliable
sensor
was
developed.
Moreover,
simultaneous
capture
visual
achieved
by
AuNC-loaded
sensing
platform,
which
exhibits
promising
performance.
This
work
provides
new
approach
design
point-of-care
also
holds
great
potential
further
development
microneedle-based
analytical
devices.
