Electroactive calcium-alginate/polycaprolactone/reduced graphene oxide nanohybrid hydrogels for skeletal muscle tissue engineering DOI Creative Commons
José Luis Aparicio-Collado, Natalia García-San-Martín, José Molina‐Mateo

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2022, Volume and Issue: 214, P. 112455 - 112455

Published: March 11, 2022

Graphene derivatives such as reduced graphene oxide (rGO) are used components of novel biomaterials for their unique electrical properties. Electrical conductivity is a crucial factor muscle cells, which electrically active. This study reports the development new type semi-interpenetrated polymer network based on two biodegradable FDA-approved biomaterials, sodium alginate (SA) and polycaprolactone (PCL), with Ca2+ ions SA crosslinker. Several drawbacks low cell adhesion weak structural stability can be improved incorporation PCL. Furthermore, this demonstrates how semi-IPN engineered rGO nanosheets (0.5% 2% wt/wt nanosheets) to produce electroactive nanohybrid composite biomaterials. The focuses microstructure enhancement physical biological properties these advanced materials, including water sorption, surface wettability, thermal behavior degradation, mechanical properties, conductivity, myogenic differentiation. results suggest formation complex nano-network different interactions between components: bonds chains induced by (egg-box model), links well themselves through ions, strong hydrogen bonding chains. significantly increases hydrogels, values in range tissue. In vitro cultures C2C12 murine myoblasts revealed that conductive hydrogels not cytotoxic greatly enhance myoblast These indicate have great potential biomedical applications related regeneration tissues, particularly skeletal tissue engineering.

Language: Английский

Injectable sodium alginate hydrogel loaded with plant polyphenol-functionalized silver nanoparticles for bacteria-infected wound healing DOI
Qinsheng Hu, Yong Nie, Jun Xiang

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 234, P. 123691 - 123691

Published: Feb. 20, 2023

Language: Английский

Citations

56
Biomaterials for Drug Delivery and Human Applications DOI Open Access
Paolo Trucillo

Materials, Journal Year: 2024, Volume and Issue: 17(2), P. 456 - 456

Published: Jan. 18, 2024

Biomaterials embody a groundbreaking paradigm shift in the field of drug delivery and human applications. Their versatility adaptability have not only enriched therapeutic outcomes but also significantly reduced burden adverse effects. This work serves as comprehensive overview biomaterials, with particular emphasis on their pivotal role delivery, classifying them terms biobased, biodegradable, biocompatible nature, highlighting characteristics advantages. The examination delves into extensive array applications for biomaterials encompassing diverse medical fields such cancer therapy, cardiovascular diseases, neurological disorders, vaccination. explores actual challenges within this domain, including potential toxicity complexity manufacturing processes. These emphasize necessity thorough research continuous development regulatory frameworks. second aim review is to navigate through compelling terrain recent advances prospects envisioning healthcare landscape where they empower precise, targeted, personalized delivery. transform staggering, promise treatments tailored individual patient needs, offering hope improved efficacy, fewer side effects, brighter future practice.

Language: Английский

Citations

55
Stimuli-Responsive Hydrogels: The Dynamic Smart Biomaterials of Tomorrow DOI Creative Commons
Myriam Neumann,

Greta Di Marco,

Dmitrii Iudin

et al.

Macromolecules, Journal Year: 2023, Volume and Issue: 56(21), P. 8377 - 8392

Published: Oct. 18, 2023

In the past decade, stimuli-responsive hydrogels are increasingly studied as biomaterials for tissue engineering and regenerative medicine purposes. Smart can not only replicate physicochemical properties of extracellular matrix but also mimic dynamic processes that crucial regulation cell behavior. Dynamic changes be influenced by hydrogel itself (isotropic vs anisotropic) or guided applying localized triggers. The resulting swelling–shrinking, shape-morphing, well patterns have been shown to influence function in a spatiotemporally controlled manner. Furthermore, use bioinks 4D bioprinting is very promising they allow biofabrication complex microstructures. This perspective discusses recent cutting-edge advances current challenges field smart engineering. Additionally, emerging trends potential future directions addressed.

Language: Английский

Citations

54
Alginate-Based Materials Loaded with Nanoparticles in Wound Healing DOI Creative Commons
Anna Froelich, Emilia Jakubowska, Monika Wojtyłko

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1142 - 1142

Published: April 4, 2023

Alginate is a naturally derived polysaccharide widely applied in drug delivery, as well regenerative medicine, tissue engineering and wound care. Due to its excellent biocompatibility, low toxicity, the ability absorb high amount of exudate, it used modern dressings. Numerous studies indicate that alginate care can be enhanced with incorporation nanoparticles, revealing additional properties beneficial healing process. Among most extensively explored materials, composite dressings loaded antimicrobial inorganic nanoparticles mentioned. However, other types antibiotics, growth factors, active ingredients are also investigated. This review article focuses on recent findings regarding novel alginate-based materials their applicability dressings, special attention paid potential use treatment chronic wounds.

Language: Английский

Citations

50
Alginate: Microbial production, functionalization, and biomedical applications DOI
Jianfei Wang, Shijie Liu, Jiaqi Huang

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 242, P. 125048 - 125048

Published: May 25, 2023

Language: Английский

Citations

46
Angiogenesis, hemocompatibility and bactericidal effect of bioactive natural polymer‐based bilayer adhesive skin substitute for infected burned wound healing DOI Creative Commons
Mina Shahriari‐Khalaji, Mamoona Sattar, Ran Cao

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 29, P. 177 - 195

Published: July 15, 2023

Thermal wounds are complex and lethal with irregular shapes, risk of infection, slow healing, large surface area. The mortality rate in patients infected burns is twice that non-infected burns. Developing multifunctional skin substitutes to augment the healing vital. Herein, we 3D printed a hydrogel scaffold comprising carboxymethyl chitosan (CMCs) oxidized alginate grafted catechol (O-AlgCat) on hydrophobic electrospun layer, forming bilayer substitute (BSS). functional layer (FL) was fabricated by physiochemical crosslinking ensure favorable biodegradability. gallium-containing or backing (BL) could mimic epidermis skin, avoiding fluid penetration offering antibacterial activity. FL contains catechol, gallium, biologically active platelet rich fibrin (PRF) adhere both tissue BL, show activity, encourage angiogenesis, cell growth, migration. bioactive BSS exhibited noticeable adhesive properties (P ≤ 0.05), significant activity faster clot formation, potential promote proliferation 0.05) migration L929 cells. Furthermore, angiogenesis significantly higher when evaluated vivo ovo. BSS-covered healed due low inflammation high collagen density. Based obtained results, be an effective treatment for burn wounds.

Language: Английский

Citations

44
Alginate-Based Encapsulation Fabrication Technique for Drug Delivery: An Updated Review of Particle Type, Formulation Technique, Pharmaceutical Ingredient, and Targeted Delivery System DOI Creative Commons
Joanne Lai, Abul Kalam Azad, Wan Mohd Azizi Wan Sulaiman

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 370 - 370

Published: March 6, 2024

Alginate is a natural biopolymer widely studied for pharmaceutical applications due to its biocompatibility, low toxicity, and mild gelation abilities. This review summarizes recent advances in alginate-based encapsulation systems targeted drug delivery. formulations like microparticles, nanoparticles, microgels, composites fabricated by methods including ionic gelation, emulsification, spray drying, freeze drying enable tailored loading, enhanced stability, sustained release kinetics. microspheres prepared or provide gastric protection colon-targeted of orally delivered drugs. nanoparticles exhibit cellular uptake tumor-targeting capabilities through the permeation retention effect. Crosslinked alginate microgels allow high loading controlled profiles. Composite gels with cellulose, chitosan, inorganic nanomaterials display improved mechanical properties, mucoadhesion, tunable Alginate-based wound dressings containing antimicrobial promote healing burns chronic wounds topical Although well-established as excipient, more extensive vivo testing needed assess clinical safety efficacy emerging prior human trials. Future opportunities include engineered combining stimuli-responsiveness, active targeting, diagnostic capabilities. In summary, this discusses techniques oral, transdermal, intravenous delivery, an emphasis on approaches enabling therapeutic outcomes.

Language: Английский

Citations

30
Polysaccharide-based materials as an eco-friendly alternative in biomedical, environmental, and food packaging DOI Creative Commons

Zahra Behrooznia,

Jhamak Nourmohammadi

Giant, Journal Year: 2024, Volume and Issue: 19, P. 100301 - 100301

Published: June 6, 2024

The global community has encountered numerous challenges concerning environmental sustainability, encompassing issues like waste generation, depletion of natural resources, air pollution, and other threats to human well-being. Consequently, the pursuit an eco-friendly environment emerged as a critical concern in recent years. Polysaccharides, being biopolymers, have garnered significant attention owing their distinctive properties that make them versatile for various applications. Numerous sustainable environmentally friendly polysaccharides, such chitosan, cellulose, starch, hyaluronic acid, alginate, inulin, been identified. This article highlights characteristics renewable categorization, potential contribute sustainability. It introduces extraction methods aimed at minimizing chemical pollution. Through careful selection diverse polysaccharides application functionalization techniques, suggests possibility obtaining suitable superabsorbent hydrogels, appropriate nanocomposites, effective scaffolds. significance utilizing polysaccharide-based materials is explored detail, emphasizing exceptional properties. Additionally, discusses applications polymers, including agriculture, biomedicine, food packaging.

Language: Английский

Citations

19
Polydiacetylene (PDA) Embedded Polymer-Based Network Structure for Biosensor Applications DOI Creative Commons
Huisoo Jang, Jisoo Jeon, Mingyeong Shin

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 66 - 66

Published: Jan. 15, 2025

Biosensors, which combine physical transducers with biorecognition elements, have seen significant advancement due to the heightened interest in rapid diagnostic technologies across a number of fields, including medical diagnostics, environmental monitoring, and food safety. In particular, polydiacetylene (PDA) is gaining attention as an ideal material for label-free colorimetric biosensor development its unique color-changing properties response external stimuli. PDA forms through self-assembly diacetylene monomers, color change occurring conjugated backbone twists stimuli such temperature, pH, chemical interactions. This enables detection biomarkers, metal ions, toxic compounds. Moreover, combination polymeric structures hydrogels further enhances sensitivity structural stability PDA-based biosensors, making them reliable effective complex biological conditions. review comprehensively examines recent research trends applications PDA–polymeric structure hybrid while discussing future directions potential advancements this field.

Language: Английский

Citations

2
Modification of Alginates to Modulate Their Physic-Chemical Properties and Obtain Biomaterials with Different Functional Properties DOI Creative Commons

Piotr Rosiak,

Ilona Latańska,

Paulina Paul

et al.

Molecules, Journal Year: 2021, Volume and Issue: 26(23), P. 7264 - 7264

Published: Nov. 30, 2021

Modified alginates have a wide range of applications, including in the manufacture dressings and scaffolds used for regenerative medicine, systems selective drug delivery, as hydrogel materials. This literature review discusses methods to modify obtain materials with new or improved functional properties. It diverse biological activity alginates. presents modification that utilize both natural synthetic peptides, describes their influence on properties The success functionalization depends reaction conditions being sufficient guarantee desired transformations provide modified desirable properties, but mild enough prevent degradation is description efficient alginate using biologically active ligands. Particular attention was paid because combination peptides leads obtaining conjugates resulting from components well completely new, different functionality.

Language: Английский

Citations

86