Nanoparticles incorporated hydrogels for delivery of antimicrobial agents: developments and trends

RSC Advances, Journal Year: 2024, Volume and Issue: 14(19), P. 13535 - 13564

Published: Jan. 1, 2024

Nanoparticle-hydrogel systems are versatile biomaterials that possess numerous advantages for biomedical applications. This review focuses on the application of nanoparticle-hydrogels system delivery antimicrobial agents.

Language: Английский

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Advancements in 3D-printable polysaccharides, proteins, and synthetic polymers for wound dressing and skin scaffolding – A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131207 - 131207

Published: March 28, 2024

Language: Английский

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An Overview of Biofilm-Associated Infections and the Role of Phytochemicals and Nanomaterials in Their Control and Prevention

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 162 - 162

Published: Jan. 24, 2024

Biofilm formation is considered one of the primary virulence mechanisms in Gram-positive and Gram-negative pathogenic species, particularly those responsible for chronic infections promoting bacterial survival within host. In recent years, there has been a growing interest discovering new compounds capable inhibiting biofilm formation. This promising antivirulence strategy that could potentially overcome antibiotic resistance issues. Effective antibiofilm agents should possess distinctive properties. They be structurally unique, enable easy entry into cells, influence quorum sensing signaling, synergize with other antibacterial agents. Many these properties are found both natural systems isolated from plants synthetic like nanoparticles nanocomposites. this review, we discuss clinical nature biofilm-associated some associated their tolerance. We focus on advantages efficacy various as therapeutic approach to control biofilms address multidrug bacteria.

Language: Английский

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Polysaccharide- and protein-based hydrogel dressings that enhance wound healing: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135482 - 135482

Published: Sept. 1, 2024

Language: Английский

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Antimicrobial Phenolic Materials: From Assembly to Function

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.

Language: Английский

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Preparation and characterization of zirconium-based metal-organic skeleton composite sodium alginate@SiO2 and its adsorption on methylene blue solution in water

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140916 - 140916

Published: Feb. 10, 2025

Language: Английский

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Advancements and Applications of Injectable Hydrogel Composites in Biomedical Research and Therapy

Gels, Journal Year: 2023, Volume and Issue: 9(7), P. 533 - 533

Published: June 30, 2023

Injectable hydrogels have gained popularity for their controlled release, targeted delivery, and enhanced mechanical properties. They hold promise in cardiac regeneration, joint diseases, postoperative analgesia, ocular disorder treatment. Hydrogels enriched with nano-hydroxyapatite show potential bone addressing challenges of defects, osteoporosis, tumor-associated regeneration. In wound management cancer therapy, they enable accelerated closure, drug delivery. also find applications ischemic brain injury, tissue cardiovascular personalized immunotherapy. This manuscript highlights the versatility injectable hydrogel nanocomposites biomedical research. Moreover, it includes a perspective section that explores future prospects, emphasizes interdisciplinary collaboration, underscores promising research applications.

Language: Английский

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Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications

Biomaterials Science, Journal Year: 2023, Volume and Issue: 12(1), P. 8 - 56

Published: Oct. 25, 2023

Hydrogels have established their significance as prominent biomaterials within the realm of biomedical research. However, injectable hydrogels garnered greater attention compared with conventional counterparts due to excellent minimally invasive nature and adaptive behavior post-injection. With rapid advancement emerging chemistry deepened understanding biological processes, contemporary been endowed an "intelligent" capacity respond various endogenous/exogenous stimuli (such temperature, pH, light magnetic field). This innovation has spearheaded revolutionary transformations across fields such tissue engineering repair, controlled drug delivery, disease-responsive therapies, beyond. In this review, we comprehensively expound upon raw materials (including natural synthetic materials) principles these advanced hydrogels, concurrently providing a detailed discussion prevalent strategies for conferring stimulus responsiveness. Finally, elucidate latest applications "smart" stimuli-responsive in domain, offering insights into prospects.

Language: Английский

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Metal nanoparticles and carbohydrate polymers team up to improve biomedical outcomes

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115695 - 115695

Published: Oct. 14, 2023

The convergence of carbohydrate polymers and metal nanoparticles (MNPs) holds great promise for biomedical applications. Researchers aim to exploit the capability matrices modulate physicochemical properties MNPs, promote their therapeutic efficiency, improve targeted drug delivery, enhance biocompatibility. Therefore, understanding various attributes both carbohydrates MNPs is key harnessing them many distinct types carbohydrate-MNP systems confer unique capabilities wound healing, tissue engineering, cancer treatment, even food packaging. Here, we introduce physicochemical/biological discuss potentials shortcomings (alone in combination) We then offer an overview on how they can be utilized outcomes. Last but not least, future perspectives toward application such are highlighted.

Language: Английский

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Polymer-Based Functional Materials Loaded with Metal-Based Nanoparticles as Potential Scaffolds for the Management of Infected Wounds

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 155 - 155

Published: Jan. 23, 2024

Wound infection due to bacterial invasion at the wound site is one of primary challenges associated with delayed healing. Microorganisms tend form biofilms that protect them from harm, leading their multidrug resistance. The alarming increase in antibiotic resistance poses a threat Hence, urgent need for novel dressing materials capable managing crucial expediting recovery. There considerable interest polymeric dressings embedded bioactive substances, such as metal-based nanoparticles, potential solutions treating microbially infected wounds. Metal-based nanoparticles have been widely used management wounds broad antimicrobial efficacy. This review focuses on polymer-based and loaded like silver, gold, magnesium oxide, or zinc oxide. When compared, oxide-loaded exhibited higher antibacterial activity against Gram-positive strains silver nanoparticle-loaded gram-negative strains. However, infused both displayed synergistic effect bacteria. Furthermore, these antibiofilm generation reactive oxygen species while accelerating closure vitro vivo.

Language: Английский

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