A Programmable Handheld Extrusion‐Based Bioprinting Platform for In Situ Skin Wounds Dressing: Balance Mobility and Customizability DOI Creative Commons
Chenmin Wang,

Chengwei Hu,

Haojin Cheng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Bioprinting technology plays a crucial role for constructing tissue substitutes. However, the mismatched scaffold shapes and poor treatment timeliness limit its clinical translational application. In situ printing that prints bioregenerants directly inside patient's body can meet needs of specific repair. This study develops smartphone controlled handheld bioprinter in skin wounds dressing. The mini be placed on any surface to create strips, complex patterns, 3D structures, equipped with microchannel needles expand functionality. size strips as well path programmed by ensure precision printed product quality. Furthermore, device not only allows smooth switching between different bioinks heterogeneous structure, but also fast uniform coverage large wound surfaces. When dealing vitro & vivo, printer effectively fill precisely close wounds, promoting healing. programmable balance mobility customizability management is expected realize potential emergency medical condition‐constrained scenarios, such battlefields or disaster areas.

Language: Английский

Wound management materials and technologies from bench to bedside and beyond DOI
Canran Wang, Ehsan Shirzaei Sani, Chia-Ding Shih

et al.

Nature Reviews Materials, Journal Year: 2024, Volume and Issue: 9(8), P. 550 - 566

Published: June 17, 2024

Language: Английский

Citations

83
3D bioprinting advanced biomaterials for craniofacial and dental tissue engineering – A review DOI Creative Commons
Hailong Xu,

Yuran Ge,

Yidan Zhang

et al.

Materials & Design, Journal Year: 2024, Volume and Issue: 241, P. 112886 - 112886

Published: March 28, 2024

The rising incidence of defects in oral and maxillofacial tissues, linked to factors such as trauma, tumors, periodontal disease, aging, poses significant challenges. Current treatments, involving autografts, allografts, synthetic graft materials, face obstacles like secondary inflammation, inadequate biocompatibility. Tissue engineering, integrating cell biology material science since the 1990s, relies heavily on biomaterial scaffolds promote adhesion, proliferation, differentiation. Traditional scaffold fabrication, including 3D printing, methods lack precision, hindering effective tissue repair by controlling distribution extracellular matrix. Biomedical engineering advancements have introduced bioprinting an innovative solution, overcoming constraints conventional scaffolds. technology enables rapid precise reconstruction damaged tissues with loaded cells, mimicking vivo environments. This paper explores key technologies inkjet-based, extrusion-based, fused deposition modeling, laser-assisted, VAT photopolymerization, freeform reversible embedding suspended hydrogels, sacrificial template printing. selection materials suitable mechanical biological properties is crucial, considering distinct requirements each technique. review provides a comprehensive survey research progress printing applications craniofacial dental serving valuable reference for future medical research.

Language: Английский

Citations

24
4D bioprinting of programmed dynamic tissues DOI Creative Commons

Jiahui Lai,

Yuwei Liu, Gang Lü

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 37, P. 348 - 377

Published: April 23, 2024

Setting time as the fourth dimension, 4D printing allows us to construct dynamic structures that can change their shape, property, or functionality over under stimuli, leading a wave of innovations in various fields. Recently, smart biomaterials, biological components, and living cells into 3D constructs with effects has led an exciting field bioprinting. bioprinting gained increasing attention is being applied create programmed cell-laden such bone, cartilage, vasculature. This review presents overview on for engineering tissues organs, followed by discussion approaches, technologies, biomaterials design, bioink requirements, applications. While much progress been achieved, complex process facing challenges need be addressed transdisciplinary strategies unleash full potential this advanced biofabrication technology. Finally, we present future perspectives rapidly evolving bioprinting, view its potential, increasingly important roles development basic research, pharmaceutics, regenerative medicine.

Language: Английский

Citations

24
Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering DOI Creative Commons
Tomasz Górnicki, Jakub Lambrinow, Afsaneh Golkar‐Narenji

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(6), P. 531 - 531

Published: March 16, 2024

Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic adds complexity to traditional cell cultivation methods. most commonly used technique involves cultivating cells on flat surface in two-dimensional format due its simplicity. A three-dimensional (3D) provide microenvironment for surrounding cells. There two main techniques obtaining 3D structures based the presence scaffolding. Scaffold-free consist spheroid technologies. Meanwhile, scaffold contain organoids all constructs that various types scaffolds, ranging from decellularized extracellular matrix (dECM) through hydrogels one extensively studied forms potential culture up 4D bioprinted biomaterials. bioprinting is important create scaffolds. versatility this allows many different inks, mainly hydrogels, as well inorganic substances. Increasing amounts data evidence vast usage engineering personalized medicine, with area application being regeneration skin musculoskeletal systems. Recent papers also indicate increasing vivo tests products which further strengthen importance branch emphasize need extensive research safe humansbiomimetic tissues organs. In review article, we recent advancements field preceded by an overview technologies led development complex type culture.

Language: Английский

Citations

22
Engineered exosomes and composite biomaterials for tissue regeneration DOI Creative Commons
Weikang Hu, Wang Wang, Zesheng Chen

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(5), P. 2099 - 2126

Published: Jan. 1, 2024

Exosomes, which are small vesicles enclosed by a lipid bilayer and released many cell types, widely dispersed have garnered increased attention in the field of regenerative medicine due to their ability serve as indicators diseases agents with therapeutic potential. Exosomes play crucial role mediating intercellular communication through transfer biomolecules, including proteins, lipids, RNA, other molecular constituents, between cells. The targeted transport proteins nucleic acids specific cells has potential enhance or impair biological functions. applications, they can be used alone combination approaches. examination unique attributes functions these factors emerged prominent study realm biomedical research. This manuscript summarizes origins properties exosomes, structural, biological, physical, chemical aspects. paper offers complete recent progress tissue repair medicine, emphasizing possible implications methods forthcoming regeneration attempts.

Language: Английский

Citations

20
Current status, challenges, and prospects of artificial intelligence applications in wound repair theranostics DOI Creative Commons
Huazhen Liu, Wenbin Sun,

Weihuang Cai

et al.

Theranostics, Journal Year: 2025, Volume and Issue: 15(5), P. 1662 - 1688

Published: Jan. 2, 2025

Skin injuries caused by physical, pathological, and chemical factors not only compromise appearance barrier function but can also lead to life-threatening microbial infections, posing significant challenges for patients healthcare systems. Artificial intelligence (AI) technology has demonstrated substantial advantages in processing analyzing image information. Recently, AI-based methods algorithms, including machine learning, deep neural networks, have been extensively explored wound care research, providing effective clinical decision support diagnosis, treatment, prognosis, rehabilitation. However, remain achieving a closed-loop system the comprehensive application of AI management, encompassing monitoring, treatment. This review comprehensively summarizes recent advancements applications repair. Specifically, it discusses AI's role injury type classification, measurement (including area depth), tissue monitoring prediction, personalized Additionally, addresses limitations faces management. Finally, recommendations repair are proposed, along with an outlook on future research directions, aiming provide scientific evidence technological further AI-driven theranostics.

Language: Английский

Citations

3
Dual physiological responsive structural color hydrogel particles for wound repair DOI
Li Wang, Lu Fan, Anne M. Filppula

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 46, P. 494 - 502

Published: Jan. 7, 2025

Language: Английский

Citations

2
Engineered hydrogel platform for diabetic wound healing DOI
Jie Cui, Jianbin Shi, Yanjun Liu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160379 - 160379

Published: Feb. 1, 2025

Language: Английский

Citations

2
Multifunctional hydrogel-based engineered extracellular vesicles delivery for complicated wound healing DOI Creative Commons
Zuhao Li,

Jinlong Liu,

Jian Song

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(11), P. 4198 - 4217

Published: Jan. 1, 2024

The utilization of extracellular vesicles (EVs) in wound healing has been well-documented.However, the direct administration free EVs via subcutaneous injection at sites may result rapid dissipation bioactive components and diminished therapeutic efficacy.Functionalized hydrogels provide effective protection, as well ensure sustained release bioactivity during process, making them an ideal candidate material for delivering EVs.In this review, we introduce mechanisms by which accelerate healing, then elaborate on construction strategies engineered EVs.Subsequently, discuss synthesis application delivery systems to enhance complicated healing.Furthermore, face wounds, functionalized with specific microenvironment regulation capabilities, such antimicrobial, anti-inflammatory, immune regulation, used loading EVs, potential approaches addressing these challenges.Ultimately, deliberate future trajectories outlooks, offering a fresh viewpoint advancement artificial intelligence (AI)-energized materials 3D bio-printed multifunctional hydrogel-based dressings biomedical applications.

Language: Английский

Citations

15
3D Printing‐Based Hydrogel Dressings for Wound Healing DOI Creative Commons
Xuan Zhou,

Xunzhou Yu,

Tingting You

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(47)

Published: Nov. 18, 2024

Abstract Skin wounds have become an important issue that affects human health and burdens global medical care. Hydrogel materials similar to the natural extracellular matrix (ECM) are one of best candidates for ideal wound dressings most feasible choices printing inks. Distinct from hydrogels made by traditional technologies, which lack bionic mechanical properties, 3D can promptly accurately create with complex bioactive structures potential promote tissue regeneration healing. Herein, a comprehensive review multi‐functional printing‐based hydrogel healing is presented. The first summarizes techniques dressings, including photo‐curing, extrusion, inkjet, laser‐assisted printing. Then, properties design approaches series bioinks composed natural, synthetic, composite polymers described. Thereafter, application in variety environments discussed depth, hemostasis, anti‐inflammation, antibacterial, skin appendage regeneration, intelligent monitoring, machine learning‐assisted therapy. Finally, challenges prospects

Language: Английский

Citations

14