Exosomes derived from Baicalin‐pretreated bone mesenchymal stem cells improve Th17/Treg imbalance after hepatic ischemia–reperfusion via FGF21 and the JAK2/STAT3 pathway DOI

Baoyan Zhang,

Linfeng Su,

Zhichao Chen

et al.

IUBMB Life, Journal Year: 2024, Volume and Issue: 76(8), P. 534 - 547

Published: Feb. 21, 2024

Baicalin is an active compound extracted from Scutellaria baicalensis with antioxidant and anti-inflammatory properties. Bone mesenchymal stem cells (BMSCs)-derived exosomes have shown promise for the treatment of hepatic ischemia-reperfusion (I/R) injury. This study aims to investigate role Baicalin-pretreated BMSCs-derived in I/R injury its mechanisms. BMSCs were pretreated or without Baicalin, their (Ba-Exo Exo) collected characterized. These administered mice via tail vein injection. Treatment Exo Ba-Exo significantly suppressed elevation ALT AST induced by Additionally, both treatments resulted a reduction liver weight-to-body weight ratio. RT-PCR results revealed significant downregulation pro-inflammatory cytokines treatment. Both improved Th17/Treg cell imbalance reduced cocultured normal cells, expression fibroblast growth factor 21 (FGF21) was elevated through After treatment, JAK2/STAT3 pathway inhibited, FOXO1 upregulated. Finally, recombinant FGF21 injected into mouse veins assess effects. Recombinant injection further inhibited pathway, increased expression, imbalance. In conclusion, this confirms protective effects against mitigates injury, achieved inducing inhibiting activating expression. Therefore, baicalin pretreatment emerges as promising strategy enhance therapeutic capability I/R.

Language: Английский

Progress in approved drugs from natural product resources DOI

Zhongwen Luo,

Fucheng Yin, Xiaobing Wang

et al.

Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(3), P. 195 - 211

Published: March 1, 2024

Language: Английский

Citations

99
The NLRP3 Inflammasome in Non-Alcoholic Fatty Liver Disease and Steatohepatitis: Therapeutic Targets and Treatment DOI Creative Commons
Lili Yu, Wei Hong,

Shen Lu

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: March 8, 2022

Non-alcoholic fatty liver disease (NAFLD) is among the most prevalent primary diseases worldwide and can develop into various conditions, ranging from simple steatosis, through non-alcoholic steatohepatitis (NASH), to fibrosis, eventually cirrhosis hepatocellular carcinoma. Nevertheless, there no effective treatment for NAFLD due complicated etiology. Recently, activation of NLPR3 inflammasome has been demonstrated be a contributing factor in development NAFLD, particularly as modulator progression initial hepatic steatosis NASH. NLRP3 inflammasome, caspase-1 platform, critical processing key pro-inflammatory cytokines pyroptosis. Various stimuli involved activate depending on diverse cellular stresses that they cause. inflammasome-related inhibitors agents have tested positive effects experimental models. Meanwhile, some drugs applied clinical studies, supporting this therapeutic approach. In review, we discuss activation, biological functions, targeting context progression. Specifically, focus different types inhibit summarize their pharmacological effectiveness treatment.

Language: Английский

Citations

82
Flavonoids improve type 2 diabetes mellitus and its complications: a review DOI Creative Commons

Xinrui Yi,

Mosi Dong,

Naifei Guo

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: May 31, 2023

The prevalence of type 2 diabetes mellitus (T2DM) is increasing every year. Medications are currently the most common therapy for T2DM. However, these medications have certain adverse effects. In order to find safe and effective ways improve this disease, researchers discovered that some natural products can decrease blood sugar. Flavonoids one essential low molecular weight phenolic chemicals in plant world, which widely exist roots, stems, leaves, flowers, fruits. They possess a variety biological activities, including organ protection, hypoglycemic, lipid-lowering, anti-oxidative anti-inflammatory Some flavonoids ameliorate T2DM its complications through anti-oxidation, action, glucose lipid metabolism regulation, insulin resistance management, etc. Hence, review aims at demonstrating potential benefits complications. This laid foundation development novel hypoglycemic from flavonoids.

Language: Английский

Citations

48
Study of Characterization, Antimicrobial, and Anticancer Potential of Albumin-Baicalin Nanoparticles in Hep3B Liver Cancer Cell Lines DOI

Baby Shakila,

Sulaiman Ali Alharbi, Tahani Awad Alahmadi

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 10, 2025

Language: Английский

Citations

2
Natural polyphenols: a potential prevention and treatment strategy for metabolic syndrome DOI
Shaohui Wang,

Qinyun Du,

Xianli Meng

et al.

Food & Function, Journal Year: 2022, Volume and Issue: 13(19), P. 9734 - 9753

Published: Jan. 1, 2022

Natural polyphenols from different plants (including vegetables, fruits, cocoa beans, teas and herbs) can be used to reduce the symptoms of metabolic syndrome (MS).

Language: Английский

Citations

50
Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis DOI Open Access
Qi Wang, Wenjun Li, Haibo Hu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 159, P. 114226 - 114226

Published: Jan. 17, 2023

Pulmonary fibrosis (PF) is a chronic and irreversible pulmonary disease, can lead to decreased lung function, respiratory failure even death. The pathogenesis research treatment strategy of PF significantly lag behind the medical progress clinical needs. this disease remains thorny problem, effective therapeutic drugs are still limited. Monomeric compounds from traditional Chinese medicine own various biological activities high safety. They play broad part in treating diseases also candidate drug for preventing PF. In paper, we reviewed mechanism action potential value anti-PF monomeric medicine. These attenuate inflammatory response, oxidative stress, epithelial mesenchymal transformation other processes through many signaling pathways, inhibit activation differentiation fibroblasts, thus contributing This review provide new ideas development efficiency with low toxicity.

Language: Английский

Citations

29
Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine DOI
Li Qiao,

Yuan Lianghao,

Gao Shijie

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(7), P. 1662 - 1692

Published: Jan. 1, 2024

In this review, we have summarized the common self-assembled mechanism of NSMs-based SANDDSs. Meanwhile, potential applications for cancer treatment and future development prospects are also prospected.

Language: Английский

Citations

15
The potential of baicalin to enhance neuroprotection and mitochondrial function in a human neuronal cell model DOI Creative Commons
Zoe Liu, Trang T. T. Truong, Chiara C. Bortolasci

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(8), P. 2487 - 2495

Published: March 19, 2024

Abstract Baicalin is a flavone glycoside derived from flowering plants belonging to the Scutellaria genus. Previous studies have reported baicalin’s anti-inflammatory and neuroprotective properties in rodent models, indicating potential of baicalin neuropsychiatric disorders where alterations numerous processes are observed. However, extent therapeutic effects remains undetermined human cell model, more specifically, neuronal cells mimic brain environment vitro. As proof concept, we treated C8-B4 (murine model) with three different doses (0.1, 1 5 μM) vehicle control (DMSO) for 24 h after liposaccharide-induced inflammation measured levels TNF-α medium by ELISA. NT2-N (human neuronal-like underwent identical treatment, followed RNA extraction, genome-wide mRNA expression profiles gene set enrichment analysis (GSEA). We also performed neurite outgrowth assays mitochondrial flux bioanalysis (Seahorse) cells. found that cells, at ≥ μM exhibited effects, lowering culture media. In positively affected transcriptionally up-regulated genes tricarboxylic acid cycle glycolysis pathway. Similarly, Seahorse showed increased oxygen consumption rate baicalin-treated an indicator enhanced function. Together, our findings confirmed mitochondria enhancing human-neuronal like Given prominence mechanisms diverse paucity therapeutics, this suggests application these altered.

Language: Английский

Citations

10
Baicalin Attenuates Oxidative Stress in a Tissue-Engineered Liver Model of NAFLD by Scavenging Reactive Oxygen Species DOI Open Access
Wen Gao, Bin Xu, Yizhi Zhang

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(3), P. 541 - 541

Published: Jan. 26, 2022

Oxidative stress plays an important role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Baicalin has been shown to exert protective effects various diseases. The mechanism baicalin's antioxidative effect NAFLD is currently unclear. aim this study was investigate and mechanisms baicalin on oxidative a new tissue-engineered model NAFLD. 3D induced by fat-supplemented medium (fatty acids, FFA group) for 8 days administered 5th day. CCK-8 assay showed that at concentrations below 100 μM had no obvious cytotoxicity. inhibited apoptosis lactate dehydrogenase release group. reduced levels reactive oxygen species malondialdehyde FFA, increased superoxide dismutase glutathione amounts. However, it did not upregulate nuclear erythroid 2-related factor 2 compared with Mitochondrial morphology partially restored after treatment, ATP5A expression mitochondrial membrane potential were increased. anion scavenging ability enhanced dose-dependent manner. In summary, reduces protects mitochondria inhibit via its own antioxidant activity.

Language: Английский

Citations

29
Baicalin—Current Trends in Detection Methods and Health-Promoting Properties DOI Creative Commons
Agata Bajek-Bil,

Marcelina Chmiel,

Aleksandra Włoch

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(4), P. 570 - 570

Published: April 10, 2023

Baicalin (7-D-glucuronic acid-5,6-dihydroxyflavone) belongs to natural flavonoids extracted from the roots of Scutellaria baicalensis, plant used in traditional Chinese medicine. It has been proven that baicalin various pharmacological activities, such as antioxidant, anti-inflammatory, anticancer, antibacterial, and anti-apoptotic ones. However, it is essential not only determine medical usefulness baicalin, but also find develop most effective methods for its extraction detection. Therefore, aim this review was summarize current detection identification present applications underlying mechanisms action. Based on latest literature, can be concluded liquid chromatography alone or together with mass spectrometry commonly method determination baicalin. Recently, new electrochemical have established, e.g., biosensors fluorescence, which better limits, sensitivity, selectivity.

Language: Английский

Citations

22