Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 692 - 692

Published: May 27, 2024

There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in broad range characteristics and biological effects. Polyphenols can be found foods drinks, including fruits, cereals, tea, coffee. Studies both vitro vivo, well clinical trials, have shown that they possess potent antioxidant activities, numerous therapeutic effects, health advantages. Dietary polyphenols demonstrated the potential to prevent many problems, obesity, atherosclerosis, high blood sugar, diabetes, hypertension, cancer, neurological diseases. In this paper, protective effects mechanisms behind them investigated detail, citing most recent available literature. This review aims provide comprehensive overview current knowledge on role preventing managing chronic The cited publications derived from vitro, human-based studies trials. A more complete understanding these naturally occurring metabolites will pave way for development novel polyphenol-rich diet drug programs. This, turn, provides further evidence their benefits.

Language: Английский

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Tea polyphenols: extraction techniques and its potency as a nutraceutical

Frontiers in Sustainable Food Systems, Journal Year: 2023, Volume and Issue: 7

Published: May 24, 2023

Usually, polyphenols help address numerous health issues caused by oxidative stress. Tea is a popular beverage (rich in polyphenols) with abundant promoting and disease prevention great health-promoting disease-prevention attributes, originating from the delicate, dried leaves of Camellia sinensis plant. has been proven to have health-boosting impacts like anti-inflammatory, anti-cancerous, anti-diabetic, aids weight loss. Cognitive impairment, also known as cognitive decline aging or other neurological disorders, become an emerging concern. polyphenols, especially phenolic acids, havegained enormous attention due their link improved function preventing decline. This review summarizes recent studies on benefits tea. Additionally, effective traditional modern techniques extract effects various diseases described.

Language: Английский

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Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2413 - 2413

Published: May 22, 2023

The emphasis on healthy nutrition is gaining a forefront place in current biomedical sciences. Nutritional deficiencies and imbalances have been widely demonstrated to be involved the genesis development of many world-scale public health burdens, such as metabolic cardiovascular diseases. In recent years, bee pollen emerging scientifically validated candidate, which can help diminish conditions through nutritional interventions. This matrix being extensively studied, has proven very rich well-balanced nutrient pool. this work, we reviewed available evidence interest source. We mainly focused richness nutrients its possible roles main pathophysiological processes that are directly linked imbalances. scoping review analyzed scientific works published last four focusing clearest inferences perspectives translate cumulated experimental preclinical into clinically relevant insights. promising uses for malnutrition, digestive health, disorders, other bioactivities could helpful readjust homeostasis (as it also true case anti-inflammatory or anti-oxidant needs), well benefits diseases, were identified. knowledge gaps identified, along with practical challenges hinder establishment fructification these uses. A complete data collection made major range botanical species allows more robust clinical information.

Language: Английский

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Phytochemical Composition of Ziziphus lotus (L.) Lam and Its Impact on the Metabolic Syndrome: A Review

Advances in Pharmacological and Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

The long‐term pathological state known as metabolic syndrome is characterized by hypertension, insulin resistance diabetes, abdominal obesity, and hyperlipidemia. Seeking healthcare strategies with fewer side effects, such herbal remedies, preferable in terms of mitigating the negative consequences synthetic medications. Ziziphus lotus (L.) (Rhamnaceae) or wild jujube, commonly “Sedra,” one best choices it contains a variety phytochemicals biologically active compounds. Several flavonoids stilbenes have been recognized primary bioactive components including rutin, hyperin, isoquercitrin, resveratrol. These polyphenols are pharmacologically broad‐spectrum beneficial effects for reducing risk factors associated syndrome. They exhibit antioxidant anti‐inflammatory properties, regulate lipid metabolism, possess antiobesity, antihypertensive, antidiabetic characteristics. However, there certain limitations to their therapeutic application, low bioavailability. Various proposed enhance pharmacokinetic profile potential future use. main goal this review explore underlying mechanisms related jujube its compounds treatment prevention

Language: Английский

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Regulation of pyroptosis by natural products in ulcerative colitis: mechanisms and therapeutic potential

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 9, 2025

Ulcerative colitis (UC), a chronic inflammatory bowel disease, is driven by dysregulated immune responses and persistent intestinal inflammation. Pyroptosis, caspase/gasdermin-mediated cell death that exacerbates mucosal damage through excessive cytokine release epithelial barrier disruption. Although pyroptosis considered to be key mechanism in the pathogenesis of UC, systematic assessment role natural products targeting pathway remains critical research gap. The purpose this review investigate regulatory effects on UC elucidate mechanisms action potential therapeutic effects. Key findings highlight polyphenols (e.g., resveratrol), flavonoids Quercetin), terpenoids as promising agents inhibit NLRP3 inflammasome activation, suppress gasdermin D cleavage, restore integrity, thereby reducing pro-inflammatory preclinical models. Current evidence shows enhanced efficacy safety when these compounds are combined with standard therapies, but clinical translation requires overcoming three barriers: limited human trial data, uncharacterized polypharmacology, suboptimal pharmacokinetics needing formulation refinement. Future should prioritize standardized animal-to-human translational models, mechanistic studies synergistic pathways, rigorous validation harness full pyroptosis-targeted therapies.

Language: Английский

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Lipid Metabolism-Related Enzyme Inhibition and Antioxidant Potential of the Extracts and Phytochemical Compounds from Trachystemon orientalis (L.) D.Don

Plant Foods for Human Nutrition, Journal Year: 2025, Volume and Issue: 80(2)

Published: April 28, 2025

Language: Английский

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Bioactive compounds in childhood obesity and associated metabolic complications: Current evidence, controversies and perspectives

Pharmacological Research, Journal Year: 2022, Volume and Issue: 187, P. 106599 - 106599

Published: Dec. 9, 2022

Obesity represents the most frequent chronic disease among children worldwide, with a significant global burden on society. Metabolically unhealthy obesity (MUO) can affect since their first years of life, and novel therapeutic strategies to tackle metabolic complications are under investigation. This review focuses bioactive compounds possible beneficial effects obesity, particularly omega-3, docosahexaenoic acid, vitamin D, biotics, polysaccharide macromolecules, polyphenols, inositols, alpha lipoic bromelaine. Our aim is summarize current evidence about in treatment highlighting recent findings use adolescents. Most studied molecules omega-3 despite heterogeneity between studies. Moreover, given emerging interest gut-brain axis link health microbiota, various studies prebiotics, probiotics, synbiotics, postbiotics macromolecules have been considered. Some preclinical seem highlight role even if clinical still discussed. Lastly, we describe inositols alpha-lipoic acid. Despite some dietary supplements be promising overweight subjects, only few them dose/response efficacy has found pediatric age. Innovative, well-designed targeted trials then needed prove these that could support standard behavioral therapy for obesity.

Language: Английский

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Patulin alleviates hepatic lipid accumulation by regulating lipogenesis and mitochondrial respiration

Life Sciences, Journal Year: 2023, Volume and Issue: 326, P. 121816 - 121816

Published: June 3, 2023

The aim of this study is to evaluate the effects patulin on hepatic lipid metabolism and mitochondrial oxidative function elucidate underlying molecular mechanisms. accumulation were evaluated in free fatty acid-treated AML12 or HepG2 cells through oil red O staining, triglyceride assay, real-time polymerase chain reaction, western blotting. Alteration capacity by treatment was determined using Seahorse analysis measure oxygen consumption rate. increased amounts droplets induced acids significantly reduced treatment. Patulin markedly activated CaMKII/AMP-activated protein kinase (AMPK)/proliferator-activated receptor-γ coactivator (PGC)-1α signaling pathway hepatocytes, expression sterol regulatory element binding 1c (SREBP-1c) lipogenic genes, genes related acid oxidation. In addition, enhanced rate phosphorylation proteins hepatocytes. anti-lipid accumulation; SREBP-1c, PGC-1α, carnitine palmitoyltransferase 1 expression; prevented compound C, an AMPK inhibitor. a potent inducer pathway, AMPK-mediated activation required for efficacy inhibit accumulation. This first report that promising bioactive prevents development worsening liver diseases, including non-alcoholic disease, improving quality metabolism.

Language: Английский

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The association between dietary intake of flavonoids and its subclasses and the risk of metabolic syndrome

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: July 5, 2023

The healthiest way to prevent metabolic syndrome (MetS) is through behavioral and nutritional adjustments. We examined the relationship between total flavonoids intake, flavonoid subclasses, clinically manifest MetS.A cross-sectional analysis was conducted among 28,719 individuals from National Health Nutrition Examination Survey (NHANES) Food Nutrient Database for Dietary Studies (FNDDS) 2007-2011 2017-2018. Two 24-h reviews were determine intake subclasses. link MetS investigated using a multivariate logistic regression model.Q2 Q3 of associated with 20 19% lower risk incident after adjusting age sex. Anthocyanidins flavanones in Q2 substantially reduced compared Q1. decreased steadily as increased 237.67 mg/d. Flavanones anthocyanidins also displayed V-shaped curves (34.37 23.13 mg/d).MetS adversely linked flavanones, anthocyanidins. Moreover, most effective doses flavonoids, 237.67, 34.37, mg/d, respectively, potentially preventing MetS.

Language: Английский

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The Role of Epigenetic Control of Mitochondrial (Dys)Function in MASLD Onset and Progression

Nutrients, Journal Year: 2023, Volume and Issue: 15(22), P. 4757 - 4757

Published: Nov. 12, 2023

Metabolic dysfunction-associated steatotic fatty liver disease (MASLD), a novel definition for NAFLD, represents one of the most common causes disease, and its incidence is increasing worldwide. It characterized by complex etiopathogenesis in which mitochondrial dysfunction exerts pivotal role together with alteration lipid metabolism, inflammation, oxidative stress. Nutrients bioactive compounds can influence such mechanisms so that changes diet lifestyle are regarded as important treatment strategies. Notably, natural exert their through epigenetic landscape, overall resulting rewiring molecular networks involved cell tissue homeostasis. Considering information, present review aims at providing evidence modifications occurring mitochondria response to context (dys)function. For this purpose, recent studies reporting effects on NAFLD/MASLD, well research showing DNA methylation non-coding RNAs-related circuits mitochondria, will be illustrated. Overall, highlight importance understanding compounds-dependent modulation improving knowledge MASLD identifying biomarkers employed effective preventative strategies or protocols.

Language: Английский

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