Vietnam Journal of Biotechnology,
Journal Year:
2024,
Volume and Issue:
22(2), P. 318 - 328
Published: June 30, 2024
Ageratum
conyzoides
L.
is
widely
used
for
the
treatment
of
skin
wound
in
some
communities
Asia,
Africa,
and
South
America,
including
Vietnam.
In
this
study,
we
demonstrated
that
70%
ethanol
extract
A.
leaves
collected
Bidoup
National
Park,
Nui
Ba,
Lam
Dong,
Vietnam
had
properties
would
be
advantageous
wounds.
Firstly,
found
contained
64.9±2.58
mgGAE/gE
polyphenols
79.33±1.03
mgQE/gE
flavonoids,
antioxidant
activity
with
IC50
131.74±2.67
µg/mL.
This
was
also
proven
to
have
antimicrobial
activities
against
pathogenic
bacteria,
S.
aureus,
P.
aeruginosa,
E.
faecalis,
coli.
We
could
inhibit
generation
nitric
oxide
LPS-activated
Raw
264.7
cells,
indicating
its
vitro
anti-inflammatory
activity.
And
finally,
first
time,
promote
proliferation
fibroblast
NIH-3T3
cell
line.
All
together,
these
findings
support
traditional
use
plant
treatment.
Journal of Pharmaceutical Analysis,
Journal Year:
2024,
Volume and Issue:
14(10), P. 100983 - 100983
Published: April 26, 2024
The
surface
plasmon
resonance
(SPR)
biosensor
technology
is
a
novel
optical
analysis
method
for
studying
intermolecular
interactions.
Owing
to
in-depth
research
on
traditional
Chinese
medicine
(TCM)
in
recent
years,
comprehensive
and
specific
identification
of
components
target
interactions
has
become
key
yet
difficult
tasks.
SPR
gradually
been
used
analyze
the
active
TCM
owing
its
high
sensitivity,
strong
exclusivity,
large
flux,
real-time
monitoring
capabilities.
This
review
sought
briefly
introduce
principle
SPR,
provide
historical
new
insights
into
application
TCM.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(8), P. e19308 - e19308
Published: Aug. 1, 2023
Pulmonary
fibrosis
is
an
enduring
and
advancing
pulmonary
interstitial
disease
caused
by
multiple
factors
that
ultimately
lead
to
structural
changes
in
normal
lung
tissue.
Currently,
a
global
with
high
degree
of
heterogeneity
mortality
rate.
Nitidine
pirfenidone
have
been
approved
for
treating
fibrosis,
the
quest
effective
therapeutic
drugs
remains
unabated.
In
recent
years,
anti-pulmonary
properties
natural
flavonoids
garnered
heightened
attention,
although
further
research
needed.
this
paper,
resources,
characteristics,
mechanisms
were
reviewed.
We
hope
provide
potential
opportunities
application
fight
against
fibrosis.
Archiv der Pharmazie,
Journal Year:
2024,
Volume and Issue:
357(10)
Published: July 3, 2024
Idiopathic
pulmonary
fibrosis
(IPF)
is
a
chronic
interstitial
lung
disease
of
unknown
etiology.
Currently,
drugs
used
to
treat
IPF
in
clinical
practice
exhibit
severe
side
effects
and
limitations.
To
address
these
issues,
this
paper
discusses
the
therapeutic
preclinical
targeted
(such
as
STAT3
TGF-β/Smad
pathway
inhibitors,
chitinase
PI3K
phosphodiesterase
etc.)
natural
products
on
IPF.
Through
summary
current
research
progress,
it
found
that
possess
multitarget
effects,
stable
efficacy,
low
nondrug
dependence.
Furthermore,
we
discuss
significant
prospects
product
molecules
combating
by
influencing
immune
system,
expecting
analytical
data
will
aid
development
new
or
investigation
active
ingredients
for
potential
treatments
future.
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(2), P. 332 - 332
Published: Feb. 4, 2024
Coronavirus
disease
2019
(COVID-19)
caused
a
severe
epidemic
due
to
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2).
Recent
studies
have
found
that
patients
do
not
completely
recover
from
infections,
but
instead,
suffer
variety
of
post-acute
sequelae
SARS-CoV-2
infection,
known
as
long
COVID.
The
effects
COVID
can
be
far-reaching,
with
duration
up
six
months
and
range
symptoms
such
cognitive
dysfunction,
immune
dysregulation,
microbiota
dysbiosis,
myalgic
encephalomyelitis/chronic
fatigue
syndrome,
myocarditis,
pulmonary
fibrosis,
cough,
diabetes,
pain,
reproductive
thrombus
formation.
However,
recent
shown
naringenin
naringin
palliative
on
various
COVID-19
sequelae.
Flavonoids
naringenin,
commonly
in
fruits
vegetables,
positive
effects,
including
reducing
inflammation,
preventing
viral
providing
antioxidants.
This
article
discusses
the
molecular
mechanisms
clinical
treating
above
diseases.
It
proposes
them
potential
drugs
for
treatment
COVID,
it
inferred
exhibit
extended
medications,
future
likely
serving
nutraceuticals
or
supplements
comprehensive
alleviation
manifestations
complications.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(10)
Published: Sept. 23, 2024
Abstract
Pulmonary
fibrosis
(PF)
is
a
chronic
and
progressive
lung
disease
characterized
by
extensive
alterations
of
cellular
fate
function
excessive
accumulation
extracellular
matrix,
leading
to
tissue
scarring
impaired
respiratory
function.
Although
our
understanding
its
pathogenesis
has
increased,
effective
treatments
remain
scarce,
fibrotic
progression
major
cause
mortality.
Recent
research
identified
various
etiological
factors,
including
genetic
predispositions,
environmental
exposures,
lifestyle
which
contribute
the
onset
PF.
Nonetheless,
precise
mechanisms
these
factors
interact
drive
are
not
yet
fully
elucidated.
This
review
thoroughly
examines
diverse
molecular
mechanisms,
key
signaling
pathways
involved
in
PF,
such
as
TGF‐β,
WNT/β‐catenin,
PI3K/Akt/mTOR.
It
also
discusses
current
therapeutic
strategies,
antifibrotic
agents
like
pirfenidone
nintedanib,
explores
emerging
targeting
senescence.
Emphasizing
need
for
omni‐target
approaches
overcome
limitations
therapies,
this
integrates
recent
findings
enhance
PF
development
more
prevention
management
ultimately
improving
patient
outcomes.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13410 - 13410
Published: Dec. 14, 2024
Nigella
sativa
(NS)
is
an
annual
herb
belonging
to
the
Ranunculaceae
family,
also
known
as
black
cumin
or
seed.
This
plant
has
been
used
since
ancient
times
due
its
therapeutic
properties
and
proven
effective
in
gastrointestinal,
respiratory,
cardiovascular,
infectious,
inflammatory
conditions.
In
this
review,
aim
highlight
effects
of
Arab
countries
“the
that
cures
any
disease”,
which
are
provided
by
phytochemical
compounds
composition,
such
thymoquinone,
p-cymene,
α-thujene,
longifolene,
β-pinene,
α-pinene,
carvacrol.
These
confer
antioxidant
effect
seeds,
leading
a
significant
decrease
ROS
potent
anti-inflammatory
effect.
Also,
NS
seeds
may
have
synergistic
with
other
drugs,
chemotherapeutic
agents
antibiotics,
lead
reduction
dose,
improved
effect,
could
overcoming
obstacles
drug
resistance.
The
studies
review
showed
potential
be
agent
both
monotherapy
adjuvant.
Although
there
demonstrating
NS,
need
for
much
more
extensive
research
clinical
trials
clearly
established
objectives
so
mechanism
action
active
substances
better
understood.
With
data
far,
can
food
production
small
quantities
administered
short
periods.
Further
investigations
understanding
profile
most
mode
administration,
well
clearer
perspective
on
toxicological
NS.
Chemistry & Biodiversity,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
ABSTRACT
Macrophages
are
heterogeneous
cells
that
the
mediators
of
tissue
homeostasis.
These
immune
originated
from
monocytes
and
classified
into
two
basic
categories,
M1
M2
macrophages.
macrophages
exhibit
anti‐tumorous
inflammatory
reactions
due
to
behavior
phagocytosis.
or
tumor‐associated
(TAMs)
most
abundant
in
tumor
microenvironment
(TME)
have
a
role
progression
by
interacting
with
other
TME.
By
expression
various
cytokines,
chemokines,
growth
factors,
TAMs
lead
strengthening
cell
proliferation,
angiogenesis,
suppression
system
which
further
support
invasion
metastasis.
This
review
discusses
recent
updated
mechanisms
regarding
Moreover,
current
therapeutic
approaches
targeting
TAMs,
their
advantages,
limitations
also
summarized,
treatment
outlined
along
an
elaboration
regression
comprehensive
article
possibly
helps
understand
underlying
comparative
way
level
advanced
one.
