Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 18, 2025
One
of
the
popular
subjects
millennia
is
synthesis
nanostructures,
their
applications
in
numerous
fields,
and
interaction
with
various
biological
systems,
making
them
appealing
for
drug
delivery
diagnostic
therapeutic
agents.
In
this
study,
silver
oxide
nanoparticles
were
synthesized
using
E.
sativa
(ES)
aqueous
extract.
The
biosynthesis
was
followed
via
UV-vis
spectroscopy
by
analysis,
FTIR,
XRD,
TEM,
Zeta
potential
to
further
analyze
nanoparticles.
Furthermore,
biosynthesized
(Ag2ONPs)
checked
through
activities.
antioxidative
assessed
performing
a
DPPH
radical
scavenging
assay,
total
reducing
power
antioxidant
capacity
assay.
Antimicrobial
observed
against
bacterial
fungal
strains.
Likewise,
Artemia
salina
(brine
shrimps)
used
study
cytotoxicity,
while
VERO
HEK-293
cell
lines
applied
check
biocompatibility
NPs.
Anticancer
evaluated
Hep-2
cells
utilizing
an
MTT
A
mean
crystallite
~
50
nm
size
evidenced
TEM
analysis.
Notable
antimicrobial
activity
detected
strains
maximum
ZOI
B.
subtilis
18.5
±
2.36
mm
at
1000
µg/mL
A.
niger
reveals
minimum
ZOP
16
1.7
respectively.
dose-dependent
response
evaluation
(LC50:
12.21
µg/mL),
(IC50:
62.36
line
43.11
26.56
9.97
µg/mL).
multifaceted
attributes
ES-Ag2ONPs
encompassing
antimicrobial,
antioxidant,
cytotoxic,
anticancer
properties
render
versatile
platform
biomedical
horizons.
However,
detailed
investigation
clinical
trials
will
undoubtedly
provide
translational
diverse
fields.
Biotechnology and Applied Biochemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
ABSTRACT
Globally,
breast
cancer
continues
to
be
the
leading
type
of
affecting
women,
with
rising
mortality
rates
projected
by
2030.
This
highlights
importance
developing
new,
affordable
treatments,
like
drug
delivery
systems
that
use
nanoparticles.
Gold
nanoparticles
(AuNPs),
including
their
exceptional
optical
and
physical
attributes,
make
them
an
attractive
vehicle
for
targeted
treatment,
allowing
accurate
focused
medication
directly
cancerous
cells
while
reducing
harmful
side
effect.
study
focuses
on
synthesis
characterization
brucine‐gold
(BRU‐AuNPs)
therapy
evaluating
antioxidant
apoptotic
mechanism.
BRU‐AuNPs
were
synthesized
characterized
(UV–Vis
spectroscopy,
Fourier
transform
infrared
[FTIR],
scanning
electron
microscopy
[SEM],
x‐ray
diffraction
[XRD],
dynamic
light
scattering
[DLS],
zeta
potential)
confirm
successful
synthesis,
size,
stability.
In
vitro
studies
assessed
using
MCF‐7
cell
lines
evaluate
cytotoxicity,
balance,
reactive
oxygen
species
(ROS)
generation,
mitochondrial
membrane
potential,
apoptosis
induction,
migration,
pro‐apoptotic
gene
expression.
Characterization
results
confirmed
average
crystal
size
85.40
nm
stable
surface
charge.
Results
demonstrated
reduced
viability
in
a
dose‐dependent
manner,
IC
50
value
11.47
µg/mL.
Treatment
altered
increased
ROS
depolarized
membranes,
induced
apoptosis.
Additionally,
inhibited
migration
upregulated
The
exhibit
potential
as
highly
effective
system
treatment.
Their
ability
deliver
BRU
tumor
effects
enhancing
therapeutic
efficacy
underscores
promise
advancing
therapy.
Further
are
warranted
explore
clinical
optimize
outcomes.
Natural Product Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 7
Published: Jan. 25, 2025
Current
study
investigates
the
medicinal
applications
of
Butea
monosperma
(Palash),
state
flower
Jharkhand,
India,
focusing
on
synthesising
biomodified
copper
oxide
nanoparticles
(CuO-NPs)
and
its
antifungal
properties.
Flavonoid
content
in
extract
was
quantified
by
aluminium
chloride
colorimetric
analysis.
CuO-NPs
were
synthesised
via
co-precipitation
method
then
modified
with
methanolic
extract.
Characterization
confirmed
properties
these
NPs
including
their
high
crystallinity,
spherical
structure
nanoscale
size
(9-90
nm
size).
Anti-fungal
activity
revealed
significant
inhibition
hyphal
growth
at
concentrations
100-1000
ppm
(76.6%
for
F.
oxysporum
75.05%
S.
rolfsii).
Statistical
computational
analysis
effectiveness
showing
strong
interactions
between
fungal
proteins.
