Effects of immune cells and cytokines on inflammation and immunosuppression in the tumor microenvironment

International Immunopharmacology, Journal Year: 2020, Volume and Issue: 88, P. 106939 - 106939

Published: Sept. 22, 2020

Language: Английский

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Global prevalence and epidemiological trends of Hashimoto's thyroiditis in adults: A systematic review and meta-analysis

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Oct. 13, 2022

Although Hashimoto's thyroiditis is associated with cardiovascular disease and malignancy, the global status of not well characterized across regions. Our objective was to evaluate prevalence trends in adults regions different economic income levels around world.For this systematic review meta-analysis, we searched PubMed, Embase, MEDLINE, Scopus, Web Science databases, 48 random-effects representative studies from inception June 2022 were included without language restrictions obtain overall worldwide. In addition, stratified by time publication, geographic region, level region residence, gender, diagnostic method, etc.A total 11,399 retrieved, which met research criteria: 20 Europe, 16 Asia, five South America, three North Africa. Furthermore, there are two projects involving 19 countries 22,680,155 participants. The 7.5 (95%CI 5.7-9.6%), while low-middle-income group 11.4 2.5-25.2%). Similarly, 5.6 (95%Cl 3.9-7.4%) upper-middle-income group, high-income 8.4 5.6-11.8). varied region: Africa (14.2 [95% CI 2.5-32.9%]), Oceania (11.0% 7.8-14.7%]), America Europe 8.0, 7.8% (95% Cl 0.0-29.5%) 5.8 2.8-9.9%) Asia. our investigator heterogeneity high (I2), results using a sensitivity analysis showed robustness reliability findings. People living areas more likely develop thyroiditis, than people areas, women's risk about four times higher men's.Global patients as many males, discrepancies levels. especially Africa, therefore local health departments should take strategic measures prevent, detect, treat thyroiditis. At same time, hidden medical burden other diseases caused also be done well.https://www.crd.york.ac.uk/prospero/, identifier: CRD 42022339839.

Language: Английский

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Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer

Cell Death Discovery, Journal Year: 2022, Volume and Issue: 8(1)

Published: July 27, 2022

Abstract Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage gasdermin family proteins. Based on accumulating evidence, pyroptosis closely associated with tumour development, but the molecular mechanism underlying activation and signalling pathways regulated remain unclear. In this review, we first briefly introduce definition, morphological characteristics, effect anticancer immunity. Then review recent progress concerning complex role in various tumours. Importantly, summarise FDA-approved chemotherapy drugs or natural compounds that exerted antitumor properties inducing cancer cells. Moreover, also focus current application nanotechnology-induced therapy. addition, some unsolved problems potential future research directions are raised.

Language: Английский

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Roles of reactive oxygen species in inflammation and cancer

MedComm, Journal Year: 2024, Volume and Issue: 5(4)

Published: April 1, 2024

Abstract Reactive oxygen species (ROS) constitute a spectrum of oxygenic metabolites crucial in modulating pathological organism functions. Disruptions ROS equilibrium span various diseases, and current insights suggest dual role for tumorigenesis the immune response within cancer. This review rigorously examines production its normal cells, elucidating subsequent regulatory network inflammation Comprehensive synthesis details documented impacts on diverse cells. Exploring intricate relationship between cancer immunity, we highlight influence existing immunotherapies, including checkpoint blockade, chimeric antigen receptors, vaccines. Additionally, underscore promising prospects utilizing targeting modulators as novel immunotherapeutic interventions discusses complex interplay ROS, inflammation, tumorigenesis, emphasizing multifaceted functions both physiological conditions. It also underscores potential implications immunotherapy suggests future research directions, development targeted therapies precision oncology approaches. In summary, this emphasizes significance understanding ROS‐mediated mechanisms advancing therapy developing personalized treatments.

Language: Английский

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Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 327, P. 117999 - 117999

Published: March 4, 2024

Traditional Chinese medicine (TCM) has been used for centuries to treat various types of inflammation and tumors the digestive system. Portulaca oleracea L. (POL), in TCM thousands years. The chemical composition POL is variable includes flavonoids, alkaloids, terpenoids organic acids other classes natural compounds. Many these compounds exhibit powerful anti-inflammatory anti-cancer-transforming effects In this review, we focus on potential therapeutic role NASH, gastritis colitis their associated cancers, with a pharmacological properties mechanisms action main active POL. information data its ingredients were collated from resources like ethnobotanical textbooks literature databases such as CNKI, VIP (Chinese literature), PubMed, Science Direct, Elsevier Google Scholar (English literatures), Wiley, Springer, Tailor Francis, Scopus, Inflibnet. Kaempferol, luteolin, myricetin, quercetin, genistein, EPA, DHA, melatonin found improve NASH NASH-HCC, while kaempferol, apigenin, quercetin played gastric cancer. Apigenin, lupeol, vitamin C have treatment cancers. discovery beneficial supports idea that could be promising novel candidate prevention inflammation-related cancers However, clinical describing mode naturally are still lacking. addition, pharmacokinetic compounds, changes drug dose absorption rates, cannot extrapolated animal models need measured patients trials. On one hand, systematic meta-analysis existing publications containing needs carried out. studies hepatic renal toxicity also needed. Additionally, well-designed preclinical validate performed, thus hopefully providing basis validation benefits

Language: Английский

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Unveiling the Link Between Chronic Inflammation and Cancer

Metabolism Open, Journal Year: 2025, Volume and Issue: 25, P. 100347 - 100347

Published: Jan. 9, 2025

The highly nuanced transition from an inflammatory process to tumorigenesis is of great scientific interest. While it well known that environmental stimuli can cause inflammation, less about the oncogenic modifications chronic inflammation in tissue microenvironment bring about, as how these set off pro-tumorigenic processes. It clear no matter where factors come from, maintaining encourages carcinogenesis. In addition encouraging angiogenesis and metastatic processes, sustaining survival proliferation malignant transformed cells, possibly altering efficacy therapeutic agents, negatively regulate antitumoral adaptive innate immune responses. Because has multiple pathways involved metastasis, gained recognition a marker cancer desirable target for therapy. Recent advances our knowledge molecular mechanisms drive cancer's progression demonstrate promotes metastasis while suppressing anti-tumor immunity. many solid tumor types, including breast, lung, liver cancer, stimulates activation oncogenes impairs body's defenses against tumor. Additionally, alters As tactical approach treatment, findings have underscored importance targeting pathways. This review highlights role development focusing on its impact progression, suppression, therapy resistance. examines current anti-inflammatory strategies, NSAIDs, cytokine modulators, STAT3 inhibitors, addressing their potential limitations. emphasizes need further research unravel complex linking identify targets specific subtypes.

Language: Английский

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Macrophages in pancreatitis: Mechanisms and therapeutic potential

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 131, P. 110693 - 110693

Published: Sept. 1, 2020

Macrophages play a crucial role in the pathogenesis of pancreatitis that is common gastrointestinal disease. Particularly, macrophages differentiate into different phenotypes and exert diverse functions acute (AP) chronic (CP), respectively. In AP, pancreas other related organs are mainly activated differentiated pro-inflammatory M1 phenotype, furthermore secrete inflammatory cytokines mediators, causing local inflammation pancreas, even intractable systemic response or multiple organ failure. CP, often exhibit M2 polarisation interact with pancreatic stellate cells (PSCs) an autocrine paracrine cytokine-dependent manner to promote progression fibrosis. As severity fibrosis aggravates, proportion M2/M1 macrophage increases. The discovery has promoted research targeted drugs, which provides great potential for effective treatment pancreatitis. This paper overview roles various current status immunotherapy targeting macrophages. findings addressed this review considerable significance understanding pivotal

Language: Английский

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A Systematic Review of the Biological Effects of Cordycepin

Molecules, Journal Year: 2021, Volume and Issue: 26(19), P. 5886 - 5886

Published: Sept. 28, 2021

We conducted a systematic review of the literature on effects cordycepin cell survival and proliferation, inflammation, signal transduction animal models. A total 1204 publications were found by cut-off date 1 February 2021. After application exclusion criteria, 791 papers remained. These read data chosen subjects extracted. 192 proliferation calculated median inhibitory concentration (IC50) 135 µM. Cordycepin consistently repressed migration (26 papers) cellular inflammation (53 papers). Evaluation 76 indicated reduced PI3K/mTOR/AKT ERK signalling activation AMPK. In contrast, p38 Jun kinases variable, as cycle arrest papers), suggesting these are cell-specific responses. The examination 150 studies that purified has many potential therapeutic effects, including reduction tumour growth (37 repression pain (9 protecting brain function (11 improvement respiratory cardiac conditions (8 19 amelioration metabolic disorders Nearly all consistent with mediating its through activating AMPK, inhibiting repressing inflammatory response. conclude excellent lead for drug development, especially age-related diseases. addition, we discuss remaining issues around mechanism action, toxicity biodistribution cordycepin.

Language: Английский

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Therapeutic Influence on Important Targets Associated with Chronic Inflammation and Oxidative Stress in Cancer Treatment

Cancers, Journal Year: 2021, Volume and Issue: 13(23), P. 6062 - 6062

Published: Dec. 1, 2021

Chronic inflammation and oxidative stress are the interconnected pathological processes, which lead to cancer initiation progression. The growing level of inflammatory damage was shown increase severity contribute tumor spread. overproduction reactive oxygen species (ROS), is associated with reduced capacity endogenous cell defense mechanisms and/or metabolic imbalance, main contributor stress. An abnormal ROS defined as a predisposing factor for transformation that could trigger pro-oncogenic signaling pathways, induce changes in gene expression, facilitate accumulation mutations, DNA damage, genomic instability. Additionally, activation transcription factors caused by prolonged stress, including NF-κB, p53, HIF1α, etc., leads expression several genes responsible inflammation. resulting hyperactivation mediators, TNFα, TGF-β, interleukins, prostaglandins can development neoplasia. Pro-inflammatory cytokines were adaptive reactions acquisition resistance cells apoptosis, while promoting proliferation, invasion, angiogenesis. Moreover, chronic response excessive production free radicals, further aggravate initiated reactions. This review summarizes recent data progress discovery associate onset metastasis. In addition, provides insights therapeutic approaches natural substances will be able simultaneously inhibit key oncological inflammation-related targets.

Language: Английский

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Emerging Roles of the Iron Chelators in Inflammation

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(14), P. 7977 - 7977

Published: July 20, 2022

Iron is a crucial element for mammalian cells, considering its intervention in several physiologic processes. Its homeostasis finely regulated, and alteration could be responsible the onset of disorders. closely related to inflammation; indeed, during inflammation high levels interleukin-6 cause an increased production hepcidin which induces degradation ferroportin. Ferroportin leads decreased iron efflux that culminates elevated intracellular concentration consequently toxicity cells tissues. Therefore, chelation considered novel useful therapeutic strategy order counteract autoimmune inflammatory diseases. Several chelators are already known have anti-inflammatory effects, among them deferiprone, deferoxamine, deferasirox, Dp44mT noteworthy. Recently, eltrombopag has been reported important role reducing inflammation, acting both directly by chelating iron, indirectly modulating efflux. This review offers overview possible biological effects suggesting as molecules.

Language: Английский

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