Prognosis and Treatment of Gastric Cancer: A 2024 Update

Cancers, Journal Year: 2024, Volume and Issue: 16(9), P. 1708 - 1708

Published: April 27, 2024

Due to the high death rate associated with gastric cancer, a great deal of research has been conducted on this disease. The goal paper was start trimestral review 2024 for year that had just started. scientific literature from 1 January chosen consideration guidelines European Society Medical Oncology (ESMO), which are updated new findings but not systematically reviewed annually. We used search term “gastric cancer” find most current publications in PubMed database related prognosis and treatment cancer. As previously said, only articles satisfied inclusion criteria were those 2024. Articles case reports eliminated since they nothing do our research. cancer is focus majority primary axes include surgery immunonutrition, immunotherapy Helicobacter pylori, therapeutic targets. Patients GC may experience less psychological, social, financial hardship if recently identified markers discovered circulation better assessed validated. This could be achieved by either including an artificial intelligence-based diagnostic score or using them conjunction traditional methods. rising GC, funding into diagnosis, prognosis, therapy, targets essential.

Language: Английский

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Chinese herbal medicine for the treatment of intestinal cancer: preclinical studies and potential clinical applications

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 1, 2024

Language: Английский

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Comprehensive Ethnopharmacological Analysis of Medicinal Plants in the UAE: Lawsonia inermis, Nigella sativa, Ziziphus spina-christi, Allium cepa, Allium sativum, Cymbopogon schoenanthus, Matricaria aurea, Phoenix dactylifera, Portulaca oleracea, Reichardia tingitana, Salvadora persica, Solanum lycopersicum, Trigonella foenum-graecum, Withania somnifera, and Ziziphus lotus

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 411 - 411

Published: Jan. 23, 2025

The United Arab Emirates (UAE) is home to diverse indigenous medicinal plants traditionally used for centuries. This study systematically evaluates the pharmacological and nutritional potential of key plants, including Lawsonia inermis, Nigella sativa, Ziziphus spina-christi, Allium cepa, sativum, Cymbopogon schoenanthus, Matricaria aurea, Phoenix dactylifera, Portulaca oleracea, Reichardia tingitana, Salvadora persica, Solanum lycopersicum, Trigonella foenum-graecum, Withania somnifera, lotus. Comprehensive literature searches were conducted using PubMed, Scopus, Web Science identify studies relevant their uses. findings highlight therapeutic roles these in managing global health challenges such as gastrointestinal diseases, antimicrobial resistance through bioactive compounds like flavonoids, polyphenols, antioxidants. Additionally, contributions nutrition, essential vitamins minerals, are emphasized disease prevention promotion. While this research focuses on UAE, implications globally relevant, many also found traditional medicine across Asia, Africa, Europe. Integrating into healthcare systems offers solutions pressing public concerns, reduces reliance synthetic pharmaceuticals, promotes sustainable practices. work a valuable reference researchers, professionals, policymakers, bridging knowledge modern scientific applications globally.

Language: Английский

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Understanding the Dual Role of Macrophages in Tumor Growth and Therapy: A Mechanistic Review

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

ABSTRACT Macrophages are heterogeneous cells that the mediators of tissue homeostasis. These immune originated from monocytes and classified into two basic categories, M1 M2 macrophages. macrophages exhibit anti‐tumorous inflammatory reactions due to behavior phagocytosis. or tumor‐associated (TAMs) most abundant in tumor microenvironment (TME) have a role progression by interacting with other TME. By expression various cytokines, chemokines, growth factors, TAMs lead strengthening cell proliferation, angiogenesis, suppression system which further support invasion metastasis. This review discusses recent updated mechanisms regarding Moreover, current therapeutic approaches targeting TAMs, their advantages, limitations also summarized, treatment outlined along an elaboration regression comprehensive article possibly helps understand underlying comparative way level advanced one.

Language: Английский

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Common Halophytes of Western India and Their Utilization

Sustainable development and biodiversity, Journal Year: 2025, Volume and Issue: unknown, P. 27 - 55

Published: Jan. 1, 2025

Language: Английский

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Huqi formula suppresses hepatocellular carcinoma growth by modulating the PI3K/AKT/mTOR pathway and promoting T cell infiltration

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 19, 2025

Abstract Background Hepatocellular carcinoma (HCC) poses ongoing difficulties for public health systems due to its high incidence and poor prognosis. Huqi formula (HQF), a well-known prescription in traditional Chinese medicine, has demonstrated notable clinical effectiveness the treatment of HCC. However, mechanisms underlying therapeutic effects have yet be completely elucidated. Purpose This study aimed investigate anti-HCC HQF mechanisms. Methods Chemical profiling quantification were conducted by LC–MS HPLC. Orthotopic subcutaneous tumor models established through hydrodynamic injection Akt/Nras plasmids c-Met/sgPten cells, respectively, evaluate on Network pharmacology, RNA-Seq, molecular docking, Western blot, flow cytometry employed assess Results analysis identified 41 components, with HPLC showing salvianolic acid B as most abundant compound (0.303%). In c-Met/sgPten-induced HCC models, significantly reduced tissue damage, improved liver function, inhibited progression. Mechanistic studies revealed that induced apoptosis cells downregulating p-PI3K, p-AKT, p-mTOR expression, docking indicating strongest binding affinity between PI3K. further enhanced CD4 + CD8 T cell infiltration within microenvironment. When combined PD-1 therapy, efficacy against Finally, toxicity assays confirmed safety profile HQF. Conclusion significant synergistic effect PD-1, could used an alternative agent Graphical

Language: Английский

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Therapeutic potential of natural products in stress granules: underlying molecular mechanisms and future perspectives

Current Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Wild grown Portulaca oleracea as a novel magnetite based carrier with in vitro antioxidant and cytotoxicity potential

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 13, 2025

The latest research on nanotechnology through the new tailored scaffolds encompassed therapeutic effects of natural compounds, and unique properties metallic nanoparticles offer possibilities in emerging biomedical fields. Various strategies have been developed to address limitations existing agents concerning specificity, vectorization, bioavailability, drug resistance, adverse effects. In this study, medicinal plant Portulaca oleracea L. magnetite were used develop an innovative target carrier system, designed enhance cytotoxic effect overcome main drawbacks (permeability localization) phytoconstituents. low-metabolite profile Romanian wild-grown exhibits a diverse range hundred fifty-five compounds across various chemical categories (amino acids, peptides, fatty flavonoids, alkaloids, terpenoids, phenolic organic esters, sterols, coumarins, nucleosides, lignans, miscellaneous compounds). Morpho-structural magnetic phytocarrier investigated using variety methods, including XRD, FTIR, Raman, SEM, DLS), determinations. MTT assay was conducted evaluate vitro potential cytotoxicity normal human dermal fibroblasts (NHDF), as well two tumoral cell lines: osteosarcoma (HOS) cervical cancer (HeLa). Results indicated that significant inhibition both lines' viability exerted by compared herbal extract. Furthermore, results obtained for total content antioxidant screening performed FRAP DPPH assays superior system. These findings suggest applications system its promising implications future development field.

Language: Английский

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Coatings Applied to the Optimization of Portulaca oleracea L. Seed Pellet Formulation Based on Mixture Design

Coatings, Journal Year: 2025, Volume and Issue: 15(3), P. 341 - 341

Published: March 15, 2025

Portulaca oleracea L. is an important herb with the same origin in medicine and food. To achieve precise sowing of P. oleracea, this study employed a mixed experimental design to optimize pellet formulation seeds. Fillers such as kaolin, bentonite, talcum powder were used, along binders including polyvinyl alcohol, sodium alginate, carboxymethyl cellulose. The physical characteristics germination properties pelletized seeds evaluated determine optimal formulation. results indicated that, after pelletizing, exhibited higher seed viability vigor, rate, index. Specifically, singulation rate correlated positively kaolin content, disintegration was proportional amount added, compression resistance bentonite ratio. Using response optimization, fillers used for pelletizing identified 17% powder, 16% 67% bentonite. Single-factor experiments showed that using PVP binder at mass fraction 10% resulted improved indices. This not only optimized based on properties, but also expanded application processing traditional Chinese herbs. It holds significant implications mechanized production small,

Language: Английский

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Dietary Phytochemicals in Health and Disease: Mechanisms, Clinical Evidence, and Applications—A Comprehensive Review

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

ABSTRACT Phytochemicals are bioactive compounds found in plants that play a key role promoting health and preventing diseases. Present fruits, vegetables, grains, seed oils, these considered safe for consumption due to the co‐evolution adaptation between mammals plants. Due their wide‐ranging biological effects, they have attracted considerable research interest. This comprehensive review explores mechanisms of action, benefits, applications dietary phytochemicals, with particular focus on groups such as polyphenols, flavonoids, carotenoids. Research shows phytochemicals interact nuclear membrane receptors, influence metabolic pathways, affect epigenetic modifications. Our highlights broad range activities compounds, including antioxidant, antibacterial, anti‐inflammatory, anti‐diabetic, anticancer all which contribute health‐promoting properties. Clinical evidence supports prevention management diseases cardiovascular disorders, conditions, cancer, diets rich being linked lower risk disease. also at cutting edge food preservation, supplements, emerging medical treatments. Additionally, we identified advancements extraction identification techniques, particularly metabolomics, further enhance areas. Despite promising challenges bioavailability, regulatory barriers, need robust clinical trials persist. However, innovative delivery systems like nanoparticles, liposomes, encapsulation offer potential solutions bioavailability by improving absorption stability. The concludes emphasizing personalized nutrition combination therapies benefits while stressing methods, trials, bioavailability.

Language: Английский

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