Cited by Alleviation of Immobilization Stress or Fecal Microbiota-Induced Insomnia and Depression-like Behaviors in Mice by Lactobacillus plantarum and Its Supplement

(R)-(-)-Ketamine: The Promise of a Novel Treatment for Psychiatric and Neurological Disorders DOI

Hana Shafique,

Julie Demers,

Julia Biesiada

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6804 - 6804

Published: June 20, 2024

NMDA receptor antagonists have potential for therapeutics in neurological and psychiatric diseases, including neurodegenerative epilepsy, traumatic brain injury, substance abuse disorder (SUD), major depressive (MDD). (S)-ketamine was the first of a novel class antidepressants, rapid-acting to be approved medical use. The stereoisomer, (R)-ketamine (arketamine), is currently under development treatment-resistant depression (TRD). compound has demonstrated efficacy multiple animal models. Two clinical studies disclosed TRD bipolar depression. A study by drug sponsor recently failed reach priori endpoints but post hoc analysis revealed efficacy. value supported experimental data humans rodents, showing that it less sedating, does not produce marked psychotomimetic or dissociative effects, than (S)-ketamine, produces models range disorders. mechanisms action antidepressant effects are hypothesized due antagonism and/or non-NMDA mechanisms. We suggest further experimentation with will create improved medicines some disorders underserved current medications.

Language: Английский

Citations

The vagus nerve: An old but new player in brain–body communication DOI

Li Ma,

Hanbing Wang,

Kenji Hashimoto

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

Role of oxidative phosphorylation in the antidepressant effects of arketamine via the vagus nerve-dependent spleen-brain axis DOI

Lijia Chang, Wei Yan, Youge Qu

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 199, P. 106573 - 106573

Published: June 18, 2024

Arketamine, the (R)-enantiomer of ketamine, exhibits antidepressant-like effects in mice, though precise molecular mechanisms remain elusive. It has been shown to reduce splenomegaly and depression-like behaviors chronic social defeat stress (CSDS) model depression. This study investigated whether spleen contributes arketamine CSDS model. We found that splenectomy significantly inhibited arketamine's CSDS-susceptible mice. RNA-sequencing analysis identified oxidative phosphorylation (OXPHOS) pathway prefrontal cortex (PFC) as a key mediator splenectomy's impact on effects. Furthermore, oligomycin A, an inhibitor OXPHOS pathway, reversed suppressive Specific genes within pathways, such COX11, UQCR11 ATP5e, may contribute these inhibitory Notably, transforming growth factor (TGF)-β1, along with appears modulate Additionally, SRI-01138, agonist TGF-β1 receptor, alleviated Subdiaphragmatic vagotomy also counteracted These findings suggest PFC play significant roles arketamine, mediated through spleen-brain axis via vagus nerve.

Language: Английский

Citations

Depression-like phenotypes in mice with hepatic ischemia/reperfusion injury: A role of gut–microbiota–liver–brain axis via vagus nerve DOI

Yong Yang, Akifumi Eguchi, Xiayun Wan

et al.

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 345, P. 157 - 167

Published: Oct. 24, 2023

Language: Английский

Citations

Beneficial effects of arketamine on the reduced bone mineral density in susceptible mice after chronic social defeat stress: Role of the gut–microbiota–bone–brain axis DOI

Xiayun Wan, Akifumi Eguchi, Lijia Chang

et al.

Neuropharmacology, Journal Year: 2023, Volume and Issue: 228, P. 109466 - 109466

Published: Feb. 15, 2023

Language: Английский

Citations

A role of splenic heme biosynthesis pathway in the persistent prophylactic actions of arketamine in lipopolysaccharide-treated mice DOI

Li Ma, Long Wang, Youge Qu

et al.

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 25, 2023

Relapse is common in remitted patients with major depressive disorder (MDD). Arketamine, an (R)-enantiomer of ketamine, has persistent prophylactic actions inflammatory model depression. However, the precise mechanisms underlying these remain unknown. Given role brain-spleen axis depression, we sought to identify splenic molecular targets that play a arketamine. Lipopolysaccharide (LPS) (1.0 mg/kg) was administered 6 days after single injection arketamine (10 or saline. RNA-sequencing analysis found altered expression heme biosynthesis II pathway. Quantitative RT-PCR revealed pretreatment blocked increased genes involved pathway LPS-treated mice, namely, 5-aminolevulinase synthase 2 (Alas2), ferrochelatase (Fech), hydroxymethylbilane (Hmbs). Interestingly, there were positive correlations between and spleen weight plasma levels pro-inflammatory cytokines. We also higher ALAS2 FECH from MDD patients. Pretreatment key intermediate precursor heme, 5-aminolaevulinic acid (300 mg/kg/day for 3 days), caused splenomegaly, cytokines, depression-like behavior low-dose LPS (0.1 mg/kg)-treated mice. inhibitor, succinyl acetone (120 had effects These data suggest novel inflammation-related Therefore, could be new target prevention relapse

Language: Английский

Citations

Pick fecal microbiota transplantation to enhance therapy for major depressive disorder DOI

Yiming Meng, Jing Sun, Guirong Zhang

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 128, P. 110860 - 110860

Published: Sept. 9, 2023

Language: Английский

Citations

A role of gut–brain axis on prophylactic actions of arketamine in male mice exposed to chronic restrain stress DOI

Li Ma, Akifumi Eguchi, Guilin Liu

et al.

Pharmacology Biochemistry and Behavior, Journal Year: 2024, Volume and Issue: 238, P. 173736 - 173736

Published: Feb. 23, 2024

Language: Английский

Citations

Subdiaphragmatic vagotomy reduces hypothalamic oxytocin expression and blood levels after oral MDMA administration in male rats DOI

Yong Yue, Xiayun Wan, Guilin Liu

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 137, P. 111260 - 111260

Published: Jan. 22, 2025

Language: Английский

Citations

Potential Molecular Mechanisms of Alcohol Use Disorder with Non-Coding RNAs and Gut Microbiota for the Development of Superior Therapeutic Application DOI

Moeka Nakashima,

Naoko Suga,

Sayuri Yoshikawa

et al.

Genes, Journal Year: 2024, Volume and Issue: 15(4), P. 431 - 431

Published: March 29, 2024

Many investigations have evaluated the expression of noncoding RNAs (ncRNAs) as well their related molecular functions and biological machineries in individuals with alcohol dependence. Alcohol dependence may be one most prevailing psychological disorders globally, its pathogenesis is intricate inadequately comprehended. There substantial evidence indicating significant links between multiple genetic factors development In particular, critical roles ncRNAs been emphasized pathology mental illnesses, probably including comprehension action modification, furthermore, they emerged therapeutic targets for a variety psychiatric It worth mentioning that dysregulated has regularly detected An in-depth knowledge m6A modification valuable novel treatment against general, more profound understanding practical might make important contributions to precise diagnosis and/or actual management Here, this review, we mostly focused on up-to-date regarding alterations modifications Then, present prospects future research applications concept engram system.

Language: Английский

Citations