Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 21, 2024
Difluoromethyl (CF
Language: Английский
Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(1), P. 108794 - 108794
Published: July 12, 2023
Language: Английский
Citations
5
Advanced Agrochem, Journal Year: 2023, Volume and Issue: 2(4), P. 349 - 355
Published: July 17, 2023
To find new pesticide candidates, by using of a natural product andrographolide as the precursor, series novel indolo[2,3-b]andrographolide derivatives were semisynthesized Fischer-indole rearrangement reaction. Their structures identified 1H NMR, IR, mp, and HRMS, steric configuration compound Ic was further determined on single-crystal analysis. Compounds If IIb showed 5.9 7.0 times potent acaricidal activity compared to against Tetranychus cinnabarinus. Compound Ib displayed 4.2 folds higher aphicidal Eriosoma lanigerum. In addition, pronounced insecticidal IIc Aphis citricola that andrographolide. Scanning electron microscopy revealed can destroy epidermis T. These results provide basis for future research botanical agrochemicals.
Language: Английский
Citations
4
ChemBioChem, Journal Year: 2024, Volume and Issue: 25(7)
Published: March 1, 2024
Abstract Pesticides are essential in agricultural development. Controlled‐release pesticides have attracted great attentions. Base on a principle of spatiotemporal selectivity, we extended the photoremovable protective group (PRPG) into agrochemical agents to achieve controllable release active ingredients. Herein, obtained NP‐TBZ by covalently linking o ‐nitrobenzyl ( NP ) with thiabendazole TBZ ). Compound can be controlled dependent light. The irradiated and unirradiated showed significant differences fungicidal activities both vitro vivo. In addition, displayed similar antifungal directly‐used , indicating factual applicability . Furthermore, explored action mode microcosmic variations SEM analysis, demonstrated that retained same against mycelia growth.
Language: Английский
Citations
1
Photochemistry and Photobiology, Journal Year: 2024, Volume and Issue: 100(6), P. 1813 - 1826
Published: March 6, 2024
Pesticides can improve crops' yield and quality, but unreasonable applications of pesticides lead to waste which are further accumulated in the environment threaten human health. Developing release controlled drugs utilization rate pesticides. Among these methods, light-controlled is a new technology release, realize spatiotemporal delivery by light. Four compounds, named Imidacloprid-Thioacetal o-nitrobenzyl-Phenamacril (IMI-TNB-PHE), o-nitrobenzyl- Imidacloprid (IMI-TNB-IMI), Phenamacril-Thioacetal (PHE-TNB-PHE), o-nitrobenzyl-Imidacloprid Synergist (IMI-TNB-IMISYN), were designed synthesized connecting thioacetal o-nitrobenzyl (TNB) with TNB displaying simple efficient optical properties this work. Dual photo-controlled including two molecules IMI or PHE, both as well IMISYN were, respectively, studied paper. Insecticidal/fungicidal activities photosensitive showed 2-4 times increments if they exposed In addition, synergistic effect was observed after IMI-TNB-IMISYN, consistent IMISYN. The results demonstrated whether dual same different pesticide could be achieved linker precision. We envisioned that will an innovative protective group for light-dependent application agrochemicals future.
Language: Английский
Citations
1
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(29), P. 16112 - 16127
Published: July 10, 2024
The active splicing strategy has witnessed improvement in bioactivity and antifungal spectra pesticide discovery. Herein, a series of simple-structured molecules (
Language: Английский
Citations
1
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 22, 2024
Azo-incorporating was reported to be an effective strategy for increasing SDH inhibitory activity but poor in vivo control effects. Herein, the azo-incorporated compounds were structurally optimized retain a preferential conformation by replacing azo bond with their bioisosteres. Interestingly, 1,2,4-oxadiazole compound
Language: Английский
Citations
1
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 20, 2024
In pursuit of potent and environmentally benign insecticides targeting the γ-aminobutyric acid (GABA) receptor, a series novel meta-diamide compounds bearing phthalimide were rationally designed synthesized. Bioassay studies revealed that most target exhibited promising larvicidal activity against Mythimna separata (M. separata) Plutella xylostella (P. xylostella). Notably, active compound N15 displayed exceptional potency with LC50 values 3.82 3.42 mg·L–1 M. P. xylostella, respectively. Electrophysiological using Xenopus oocytes confirmed exerted its insecticidal by GABA receptors.
Language: Английский
Citations
1
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 20, 2024
Photopharmacology, an emerging interdisciplinary field, enables precise modulation of target biological activity by employing light-controllable photoswitchable molecules. The research on nicotinamidase (Naam), a recently identified molecule for pesticides, remains relatively underexplored. Therefore, based the structure its inhibitor Flonicamid, we designed and synthesized series photopharmacological ligands (FABS) incorporating azobenzene switch, further investigating their effects insect behavior activity. Compound FAB03 exhibited LC50 value 32.8 μM before light exposure 154 after against Aedes albopictus, indicating 4.7-fold difference in FAB05 0.691 2.85 nymphs (1 day old) Aphis craccivora, 4.1-fold Additionally, this has successfully achieved light-mediated locomotor both Drosophila melanogaster A. albopictus larvae. Fluorescence staining experiments with larvae were conducted to explore potential modes action drug. Calcium content analysis showed that Flonicamid at 20 μg/mL significantly caused inward Ca2+ flux ovarian Spodoptera frugiperda (SF9), trans-configurations also led certain increase concentration intracellular Ca2+. AlphaFold2 was employed predict three-dimensional Naam, binding elucidated through molecular docking studies.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139360 - 139360
Published: Dec. 1, 2024
Language: Английский
Citations
1
Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(44), P. 16533 - 16541
Published: Oct. 25, 2023
Caged plant growth regulators (caged PGRs) that release bioactive molecules under irradiation are critical in enhancing the efficacy and mitigating negative environmental effects of PGRs. The synthetically derived inhibitor exo-16,17-dihydro-gibberellin A5-13-acetate (DHGA5) regulates development stress resilience plants. We report here conception novel caged DHGA5 derivatives wherein photoremovable protecting groups (PRPGs) serve not only to enable light-controlled but also protect carboxyl group during chemical synthesis. Three o-nitrobenzyl-based with different substituents on nitrobenzyl moiety were obtained evaluated for their properties vitro vivo. photolysis half-life values 7a, 7b, 7c a UV lamp 15.6 h, 1.2 28.2 respectively. Experiments vivo showed 0.2 mM compounds significantly inhibited model Arabidopsis thaliana important crop rice precise photoactivated form.
Language: Английский
Citations
2