Selenization of Small Molecule Drugs: A New Player on the Board

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(10), P. 7759 - 7787

Published: May 8, 2024

There is an urgent need to develop safer and more effective modalities for the treatment of a wide range pathologies due increasing rates drug resistance, undesired side effects, poor clinical outcomes, etc. Throughout years, selenium (Se) has attracted great deal attention its important role in human health. Besides, growing body work unveiled that inclusion Se motifs into number molecules promising strategy obtaining novel therapeutic agents. In current Perspective, we have gathered most recent literature related incorporation different moieties scaffolds known drugs their feasible pharmaceutical applications. addition, highlight representative examples as well provide our perspective on possible future directions, promises, opportunities, challenges this ground-breaking area research.

Language: Английский

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Injectable hydrogel with selenium nanoparticles delivery for sustained glutathione peroxidase activation and enhanced osteoarthritis therapeutics

Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100864 - 100864

Published: Nov. 11, 2023

Reactive oxygen burst in articular chondrocytes is a major contributor to osteoarthritis progression. Although selenium indispensable role the antioxidant process, narrow therapeutic window, delicate toxicity margins, and lack of an efficient delivery system have hindered its translation clinical applications. Herein, transcriptomic biochemical analyses revealed that was associated with metabolic abnormality. A novel injectable hydrogel deliver nanoparticles (SeNPs) proposed intervene selenoprotein expression for treatment. The hydrogels based on oxidized hyaluronic acid (OHA) cross-linked acid-adipic dihydrazide (HA-ADH) formulated load SeNPs through Schiff base reaction. were further incorporated SeNPs, which exhibited minimal toxicity, mechanical properties, self-healing capability, sustained drug release. Encapsulated facilitated cartilage repair synergetic effects scavenging reactive species (ROS) depressing apoptosis. Mechanistically, restored redox homeostasis by targeting glutathione peroxidase-1 (GPX1). Therapeutic outcomes SeNPs-laden demonstrated rat model created destabilization medial meniscus, including protection, subchondral bone sclerosis improvement, inflammation attenuation, pain relief demonstrated. These results highlight potential OHA/HA-ADH@SeNPs hydrogels, providing fundamental insights into remedying imbalance biomaterial development.

Language: Английский

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Unveiling Green Synthesis and Biomedical Theranostic paradigms of Selenium Nanoparticles (SeNPs) - A state-of-the-art comprehensive update

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124535 - 124535

Published: Aug. 1, 2024

The advancements in nanotechnology, pharmaceutical sciences, and healthcare are propelling the field of theranostics, which combines therapy diagnostics, to new heights; emphasizing emergence selenium nanoparticles (SeNPs) as versatile theranostic agents. This comprehensive update offers a holistic perspective on recent developments synthesis applications SeNPs, underscoring their growing importance nanotechnology healthcare. SeNPs have shown significant potential multiple domains, including antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic, wound healing, cytoprotective therapies. review highlights adaptability biocompatibility crucial for advanced disease detection, monitoring, personalized treatment. Special emphasis is placed green techniques, eco-friendly cost-effective benefits biosensing, imaging therapeutic applications. Additionally, appraisal scrutinizes progressive trends smart stimuli-responsive conferring role innovative solutions management diagnostics. Despite promising prophylactic potential, also present several challenges, particularly regarding toxicity concerns. These challenges implications clinical translation thoroughly explored, providing balanced view current state prospects

Language: Английский

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Porous Se@SiO2 nanospheres alleviate diabetic retinopathy by inhibiting excess lipid peroxidation and inflammation

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Feb. 6, 2024

Abstract Background Lipid peroxidation is a characteristic metabolic manifestation of diabetic retinopathy (DR) that causes inflammation, eventually leading to severe retinal vascular abnormalities. Selenium (Se) can directly or indirectly scavenge intracellular free radicals. Due the narrow distinction between Se’s effective and toxic doses, porous Se@SiO2 nanospheres have been developed control release Se. They exert strong antioxidant anti-inflammatory effects. Methods The effect anti-lipid effects Se@SiO 2 on mice were assessed by detecting level Malondialdehyde (MDA), glutathione peroxidase 4 (GPX4), decreased reduced/oxidized (GSH/GSSG) ratio, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL) -1β retina. To further examine protective vasculopathy mice, acellular capillary, expression tight junction proteins, blood–retinal barrier destruction was observed. Finally, we validated GPX4 as target via detected MDA, GSH/GSSG, TNF-α, IFN-γ, IL -1β, wound healing assay, tube formation in high glucose (HG) cultured Human microvascular endothelial cells (HRMECs). Results reduced while increasing GSH/GSSG mice. Therefore, number capillaries, depletion leakage Further, identified inhibition repression peroxidation, anti-inflammatory, cell dysfunction HG-cultured HRMECs. Conclusion Porous effectively attenuated inhibiting excess lipid inflammation GPX4, suggesting their potential therapeutic agents for DR.

Language: Английский

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Multifunctional Selenium-Based Metal Polyphenol Nanoparticles Impede the Pathological Cross-talk Between Reactive Oxygen Species and Inflammation in Sepsis

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(6), P. 2434 - 2445

Published: May 20, 2024

Oxidative stress and dysregulated inflammation lead to a detrimental loop in sepsis, which results cytokine storms multiorgan failure. Development of high-performance nanozyme impede the pathological cross-talk is an effective strategy. Herein, we develop multifunctional tannic acid-Zn-coated selenium nanoparticles (TZn@CSe) with superoxide dismutase glutathione peroxidase-like enzyme activities, can effectively neutralize various types ROS decrease expression iNOS. Furthermore, they reversed polarization M1 macrophages reduced inflammatory cytokines. Mechanistic assays revealed that TZn@CSe significantly modulated oxidative response signaling pathways, thereby alleviating storms. Eventually, increased survival rate septic mice by 50% ameliorated damage lungs, therapeutic efficacy surpassed first-line clinical drug. Our work provides feasible method for sepsis intercept interplay between inflammation.

Language: Английский

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Synthesis and Application of Selenium Nanoparticles for the Modulation of Inflammatory Diseases

Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Exploring the Link between Oxidative Stress, Selenium Levels, and Obesity in Youth

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7276 - 7276

Published: July 2, 2024

Obesity is a worldwide increasing concern. Although in adults this easily estimated with the body mass index, children, who are constantly growing and whose bodies changing, reference points to assess weight status age gender, need corroboration complementary data, making their quantification highly difficult. The present review explores interaction spectrum of oxidative stress, selenium status, obesity children adolescents. Any factor related stress that triggers and, conversely, induces part vicious circle, complex chain mechanisms derive from each other reinforce serious health consequences. Selenium its compounds exhibit key antioxidant activity also have significant role nutritional evaluation obese children. balance intake, retention, metabolism emerges as vital aspect health, reflecting interactions between diet, obesity. Understanding whether contributor or consequence could inform interventions public strategies aimed at preventing managing an early age.

Language: Английский

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Porphyra haitanensis polysaccharide-functionalized selenium nanoparticles for effective alleviation of ulcerative colitis

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127570 - 127570

Published: Oct. 20, 2023

Language: Английский

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Protective Effects of Selenium Nanoparticles against Bisphenol A-Induced Toxicity in Porcine Intestinal Epithelial Cells

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7242 - 7242

Published: April 14, 2023

Bisphenol A (BPA) is widely used to harden plastics and polycarbonates causes serious toxic effects in multiple organs, including the intestines. Selenium, as an essential nutrient element for humans animals, exhibits a predominant effect various physiological processes. Selenium nanoparticles have attracted more attention due their outstanding biological activity biosafety. We prepared chitosan-coated selenium (SeNPs) further compared protective effects, investigated underlying mechanism of SeNPs inorganic (Na2SeO3) on BPA-induced toxicity porcine intestinal epithelial cells (IPEC-J2). The particle size, zeta potential, microstructure were detected by using nano-selenium size meter transmission electron microscope. IPEC-J2 exposed BPA alone or simultaneously Na2SeO3. CCK8 assay was performed screen optimal concentration exposure Na2SeO3 treatment. apoptosis rate flow cytometry. Real-time PCR Western blot methods analyze mRNA protein expression factors related tight junctions, apoptosis, inflammatory responses endoplasmic reticulum stress. Increased death morphological damage observed after exposure, these increases attenuated disturbed junction function involved with decreased Zonula occludens 1 (ZO-1), occludin, claudin-1 proteins. Proinflammatory response mediated transcription factor nuclear factor-k-gene binding (NF-κB), such elevated levels interleukin-1β(IL-1β), interleukin-6 (IL-6), interferon-γ (IFN-γ), interleukin-17 (IL-17), tumor necrosis factor-α (TNF-α) induced at 6 24 h exposure. also oxidant/antioxidant status led oxidative cell indicated increased BCL-2-associated X (Bax), caspase 3, 8, 9 B-cell lymphoma-2 (Bcl-2) Bcl-xl expression. activated stress (ERS) receptor kinase receptor-like (PERK), Inositol requiring enzyme (IRE1α), activating (ATF6). found that treatment can alleviate caused BPA. superior counteracted injury, proinflammatory response, stress, ERS Our findings suggest protect from damage, partly through inhibiting ER activation subsequently attenuating suppressing thus enhancing barrier function. data indicate may represent effective reliable tool preventing animals humans.

Language: Английский

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A review of recent developments in the application of nanostructures for sperm cryopreservation

Cryobiology, Journal Year: 2024, Volume and Issue: 115, P. 104890 - 104890

Published: April 3, 2024

Language: Английский

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