Zero-dimensional nano-carbons: Synthesis, properties, and applications

Applied Physics Reviews, Journal Year: 2024, Volume and Issue: 11(2)

Published: April 19, 2024

Zero-dimensional (0D) nano-carbons, including graphene quantum dots, nanodiamonds, and carbon represent the new generation of carbon-based nanomaterials with exceptional properties arising from diverse phenomena, such as surface, size, edge effects, which strongly depend on carbon–carbon bond configuration (sp2, sp3, a mixture sp2 sp3) particle size. Their unique physicochemical properties, optical, electronic, magnetic, reactivity, catalytic are valuable for energy conversion storage, sensing, catalysis, optoelectronic devices, modern nanotechnologies, biomedical, many other applications. This review aims to provide insights into distinctive effects 0D nano-carbon microstructures their that crucial cutting-edge fundamental studies broad range multifunctional The key synthesis methods different types nano-carbons current advances characterization computational techniques study structures structure–property relationships also discussed. concludes status, challenges, future opportunities in this rapidly developing research field.

Language: Английский

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Diagnostics and analysis of SARS-CoV-2: current status, recent advances, challenges and perspectives

Chemical Science, Journal Year: 2023, Volume and Issue: 14(23), P. 6149 - 6206

Published: Jan. 1, 2023

The disastrous spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has induced public healthcare issues and weakened the global economy significantly. Although SARS-CoV-2 infection is not as fatal initial outbreak, many infected victims suffer from long COVID. Therefore, rapid large-scale testing critical in managing patients alleviating its transmission. Herein, we review recent advances techniques to detect SARS-CoV-2. sensing principles are detailed together with their application domains analytical performances. In addition, advantages limits each method discussed analyzed. Besides molecular diagnostics antigen antibody tests, also neutralizing antibodies emerging variants. Further, characteristics mutational locations different variants epidemiological features summarized. Finally, challenges possible strategies prospected develop new assays meet diagnostic needs. Thus, this comprehensive systematic detection technologies may provide insightful guidance direction for developing tools diagnosis analysis support effective long-term pandemic management control.

Language: Английский

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Afterglow Nanoprobe-Enabled Quantitative Lateral Flow Immunoassay by a Palm-Size Device for Household Healthcare

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(12), P. 4891 - 4900

Published: March 11, 2024

Lateral flow immunoassay (LFIA), a classical point-of-care testing (POCT) technique, plays an important role in disease screening and healthcare monitoring. However, traditional LFIA is either designed for qualitative analysis or requires expensive equipment quantification, limiting its use household diagnosis. In this study, we proposed new generation of health monitoring by using ultralong organic phosphorescence (UOP) nanomaterials as afterglow nanoprobes with self-developed palm-size sensing device. The UOP exhibit signal second-level lifetime, which completely avoids the interference from excitation light biological background fluorescence. Therefore, ultraminiaturized low-cost nanosensor was successfully eliminating complex optical path filtering systems. We chose inflammatory factor, C-reactive protein (CRP), POCT validation. whole completed within 9 min. A limit detection (LOD) 0.54 ng/mL CRP antigen achieved high stability good specificity, comparable to laboratory instruments fully satisfying clinical diagnosis requirement.

Language: Английский

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Recent advances in low‐background luminescent nanomaterials‐enhanced lateral flow assays for clinical diagnosis

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Lateral flow assays (LFAs) are widely applicable in clinical point‐of‐care testing (POCT) due to their unique advantages such as simplicity, rapidity, and cost‐effectiveness. However, sensitivity is often constrained by the background autofluorescence of biological sample, self‐matrix, or readout technique, thereby leading overlooking trace amounts biomarkers present early disease. In recent years, various nanomaterials‐based methods have been developed address this issue, including time‐gated wavelength‐differentiated strategy external modulated for separation minimize interference from samples. This review provides a comprehensive overview low‐background luminescent nanoparticles (LBLNPs)‐enhanced LFA systems, focusing on analyzing underlying mechanism these nanomaterials improving accuracy LFAs platform diagnosis. Representative examples selected demonstrate potential detecting disease‐associated samples blood, urine, saliva et al. Finally, unresolved challenges future development prospects briefly discussed.

Language: Английский

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Recent Development of Fluorescent Nanodiamonds for Optical Biosensing and Disease Diagnosis

Biosensors, Journal Year: 2022, Volume and Issue: 12(12), P. 1181 - 1181

Published: Dec. 19, 2022

The ability to precisely monitor the intracellular temperature directly contributes essential understanding of biological metabolism, signaling, thermogenesis, and respiration. heat generation its measurement can also assist in prediction pathogenesis chronic diseases. However, thermometry without altering biochemical reactions cellular membrane damage is challenging, requiring appropriately biocompatible, nontoxic, efficient biosensors. Bright, photostable, functionalized fluorescent nanodiamonds (FNDs) have emerged as excellent probes for magnetometry with spatial resolution on a nanometer scale. magnetic field-dependent luminescence naturally occurring defects diamonds are key high-sensitivity biosensing applications. Alterations surface chemistry FNDs conjugation polymer, metallic, nanoparticles opened vast possibilities drug delivery, diagnosis, nanomedicine, hyperthermia. This study covers some recently reported research focusing thermometry, sensing, emerging applications artificial intelligence (AI) biomedical imaging. We extend application biosensors toward disease diagnosis by using intracellular, stationary, time-dependent information. Furthermore, potential machine learning (ML) AI algorithms developing revolutionize any future outbreak.

Language: Английский

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Development of a high-throughput centrifugal microsystem for enzyme-linked immunosorbent assay to detect SARS-CoV-2

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 472, P. 144808 - 144808

Published: July 17, 2023

Language: Английский

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Nanodiamonds in biomedical research: Therapeutic applications and beyond

PNAS Nexus, Journal Year: 2024, Volume and Issue: 3(5)

Published: April 30, 2024

Abstract Nanodiamonds (NDs) comprise a family of carbon-based nanomaterials (i.e. diameter <100 nm) with the same sp3 lattice structure that gives natural diamonds their exceptional hardness and electrical insulating properties. Among all carbon nanomaterials—e.g. nanotubes, nanodots, fullerenes—NDs are particular interest for biomedical applications because they offer high biocompatibility, stability in vivo, dynamic surface chemistry can be manipulated to perform seemingly limitless variety ultra-specific tasks. NDs already deepening our understanding basic biological processes, while numerous laboratories continue studying these an aim making seismic improvements prevention, diagnosis, treatment human diseases. This review surveys approximately 2,000 most recent articles published last 5 years includes references more than 150 relevant publications on NDs. The findings categorized by contemporary lines investigation based potential applications, namely: genetics gene editing, drug delivery systems, neural interfacing, sensors, synthetic biology, organ tissue regeneration. also brief background methods currently developed synthesis preparation. Finally, recommendations future investigations offered.

Language: Английский

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An Advanced Healthcare Sensing Platform for Direct Detection of Viral Proteins in Seconds at Femtomolar Concentrations via Aerosol Jet 3D‐Printed Nano and Biomaterials

Advanced Materials Interfaces, Journal Year: 2024, Volume and Issue: 11(14)

Published: March 12, 2024

Abstract Sensing of viral antigens has become a critical tool in combating infectious diseases. Current sensing techniques have tradeoff between sensitivity and time detection; with 10–30 min detection at relatively low 6–12 h high (picomolar) sensitivity. In this research, uniquely nanoengineered interfaces are demonstrated on 3D electrodes that enable the spike SARS‐CoV‐2 their variants seconds femtomolar concentrations excellent specificity, thus, overcoming tradeoff. The electrodes, manufactured using high‐resolution aerosol jet nanoprinter, consist microelectrode array sintered gold nanoparticles coated graphene antibodies specific to severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) antigens. An impedance‐based modality is employed sense several pseudoviruses concern (VOCs). This device sensitive most VOCs. A 100 f m , along limit‐of‐detection 9.2 within test range 0.1–1000 p 43 s shown. work illustrates effective nano‐bioengineering can be used create an ultrafast ultrasensitive healthcare diagnostic for emerging infections.

Language: Английский

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Recent Advances in Lateral Flow Assays for Viral Protein Detection with Nanomaterial-Based Optical Sensors

Biosensors, Journal Year: 2024, Volume and Issue: 14(4), P. 197 - 197

Published: April 17, 2024

Controlling the progression of contagious diseases is crucial for public health management, emphasizing importance early viral infection diagnosis. In response, lateral flow assays (LFAs) have been successfully utilized in point-of-care (POC) testing, emerging as a viable alternative to more traditional diagnostic methods. Recent advancements virus detection primarily leveraged methods such reverse transcription–polymerase chain reaction (RT-PCR), transcription–loop-mediated isothermal amplification (RT-LAMP), and enzyme-linked immunosorbent assay (ELISA). Despite their proven effectiveness, these conventional techniques are often expensive, require specialized expertise, consume significant amount time. contrast, LFAs utilize nanomaterial-based optical sensing technologies, including colorimetric, fluorescence, surface-enhanced Raman scattering (SERS), offering quick, straightforward analyses with minimal training infrastructure requirements detecting proteins biological samples. This review describes composition mechanism recent protein detection, categorizing them into fluorescent, SERS-based techniques. progress, developing simple, stable, highly sensitive, selective LFA system remains formidable challenge. Nevertheless, an advanced promises not only enhance clinical diagnostics but also extend its utility environmental monitoring beyond, demonstrating potential revolutionize both healthcare safety.

Language: Английский

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Nanomaterial-based biosensors for avian influenza virus: A new way forward

Talanta, Journal Year: 2023, Volume and Issue: 265, P. 124892 - 124892

Published: July 8, 2023

Language: Английский

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