Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Sept. 25, 2024
Infectious
diseases
represent
a
significant
global
health
challenge,
with
bacteria,
fungi,
viruses,
and
parasitic
protozoa
being
causative
agents.
The
shared
symptoms
among
the
emergence
of
new
pathogen
variations
make
diagnosis
treatment
complex.
Conventional
diagnostic
methods
are
laborious
intricate,
underscoring
need
for
rapid,
accurate
techniques.
Aptamer-based
technologies
offer
promising
solution,
as
they
cost-effective,
sensitive,
specific,
convenient
molecular
disease
diagnosis.
Aptamers,
which
single-stranded
RNA
or
DNA
sequences,
serve
nucleotide
equivalents
monoclonal
antibodies,
displaying
high
specificity
affinity
target
molecules.
They
structurally
robust,
allowing
long-term
storage
without
substantial
activity
loss.
Aptamers
find
applications
in
diverse
fields
such
drug
screening,
material
science,
environmental
monitoring.
In
biomedicine,
extensively
studied
biomarker
detection,
diagnostics,
imaging,
targeted
therapy.
This
comprehensive
review
focuses
on
utility
aptamers
managing
infectious
diseases,
particularly
realms
diagnostics
therapeutics.
Analytical Chemistry,
Journal Year:
2022,
Volume and Issue:
94(51), P. 17819 - 17826
Published: Dec. 13, 2022
Dengue
fever
is
a
global
mosquito-borne
viral
infectious
disease
that
has,
in
recent
years,
rapidly
spread
to
almost
all
regions
of
the
world.
Lack
vaccination
and
directed
treatment
makes
detection
at
infection's
early
stages
extremely
important
for
prevention
clinical
care.
In
this
paper,
we
developed
rapid
highly
sensitive
dengue
tool
using
novel
platform
diagnosis,
called
spin-enhanced
lateral
flow
immunoassay
(SELFIA)
with
fluorescent
nanodiamond
(FND)
as
reporter.
Taking
advantage
unique
magneto-optical
properties
negatively
charged
nitrogen-vacancy
centers
FND,
SELFIA
utilizes
alternating
electromagnetic
fields
modulate
signals
from
FND's
fluorescence
provide
specific
results.
With
sandwich
SELFIA,
could
efficiently
detect
four
non-structural
protein
(NS1)
serotypes
(DV1,
DV2,
DV3,
DV4).
The
lowest
concentration
NS1
antigens
varied
0.1
1.3
ng/mL,
which
among
limits
date.
FND-based
technique
up
500
5000
times
more
than
carbon
black
conventional
gold
nanoparticles,
respectively.
By
different
anti-NS1
antibodies,
differentiate
antigen
contained
tested
samples
via
three
simultaneous
assays.
Proposed
allows
both
qualitative
quantitative
differentiation
between
serotypes,
will
assist
development
screening
has
potential
its
stages,
especially
high-risk
limited-resource
areas.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 18, 2024
Here
we
show
that
gradient
force
optical
tweezers
can
be
used
to
mediate
the
self-assembly
of
nanodiamonds
into
superstructures,
which
serve
as
optically
trapped
nanoscale
quantum
probes
with
superior
magnetic
resonance
sensing
capabilities.
Enhanced
fluorescence
rates
from
nitrogen-vacancy
NV
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Sept. 25, 2024
Infectious
diseases
represent
a
significant
global
health
challenge,
with
bacteria,
fungi,
viruses,
and
parasitic
protozoa
being
causative
agents.
The
shared
symptoms
among
the
emergence
of
new
pathogen
variations
make
diagnosis
treatment
complex.
Conventional
diagnostic
methods
are
laborious
intricate,
underscoring
need
for
rapid,
accurate
techniques.
Aptamer-based
technologies
offer
promising
solution,
as
they
cost-effective,
sensitive,
specific,
convenient
molecular
disease
diagnosis.
Aptamers,
which
single-stranded
RNA
or
DNA
sequences,
serve
nucleotide
equivalents
monoclonal
antibodies,
displaying
high
specificity
affinity
target
molecules.
They
structurally
robust,
allowing
long-term
storage
without
substantial
activity
loss.
Aptamers
find
applications
in
diverse
fields
such
drug
screening,
material
science,
environmental
monitoring.
In
biomedicine,
extensively
studied
biomarker
detection,
diagnostics,
imaging,
targeted
therapy.
This
comprehensive
review
focuses
on
utility
aptamers
managing
infectious
diseases,
particularly
realms
diagnostics
therapeutics.
