Nanophotonics,
Journal Year:
2021,
Volume and Issue:
10(12), P. 3089 - 3134
Published: Sept. 2, 2021
Abstract
Cancer
is
the
second
leading
cause
of
death
worldwide
after
cardiovascular
disease.
Depending
on
type
and
location
tumor,
several
cancer
treatments
are
implemented.
Among
these,
three
most
conventional
therapies
surgery,
radiotherapy
chemotherapy.
However,
there
other
therapeutic
approaches
such
as
photodynamic
therapy
(PDT).
PDT
relies
combined
action
light,
a
photoactivable
molecule
called
photosensitizer
(PS)
molecular
oxygen.
Most
PSs
used
for
clinical
applications
not
cancer-cell
specific.
One
solutions
to
overcome
this
problem
use
nanoparticles
(NPs)
induce
passive
targeting.
It
also
possible
graft
vector
onto
NPs
specifically
target
membrane
receptors
overexpressed
in
tumor
cells
or
neovessels
surrounding
tumor.
In
review,
we
focus
loaded
with
coupled
peptides
targeted
PDT.
We
described
nanosystems
that
Neuropilin-1
(NRP-1),
α
v
β
3
integrins,
nucleolin
receptor,
epidermal
growth
factor
(EGF)
protein-glutamine-gamma-glutamyltransferase
(TGM2),
p32,
transferrin,
PD-1,
mitochondrial
membrane.
The
cell
absorbing-peptide
described.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(2), P. 186 - 186
Published: Jan. 13, 2024
Cancer
is
a
severe
disease
that,
in
2022,
caused
more
than
9.89
million
deaths
worldwide.
One
worrisome
type
of
cancer
bone
cancer,
such
as
osteosarcoma
and
Ewing
tumors,
which
occur
frequently
infants.
This
study
shows
an
active
interest
the
use
graphene
oxide
its
derivatives
therapy
against
cancer.
We
present
systematic
review
analyzing
current
state
art
related
to
GO
treating
osteosarcoma,
through
evaluating
existing
literature.
In
this
sense,
studies
focused
on
GO-based
nanomaterials
for
potential
applications
were
reviewed,
has
revealed
that
there
excellent
trend
toward
nanomaterials,
based
their
thermal
anti-cancer
activities,
treatment
various
therapeutic
approaches.
However,
research
needed
develop
highly
efficient
localized
therapies.
It
suggested,
therefore,
photodynamic
therapy,
photothermal
nanocarriers
should
be
considered
non-invasive,
specific,
alternatives
osteosarcoma.
These
options
promising
approaches
enhance
effectiveness
while
also
seeking
reduce
side
effects
minimize
damage
surrounding
healthy
tissues.
The
bibliometric
analysis
photochemical
treatments
reduced
from
January
2004
December
2022
extracted
948
documents
with
search
strategy,
mainly
papers,
conference
demonstrating
high-impact
field
supported
by
need
selective
central
countries
leading
are
United
States,
Iran,
Italy,
Germany,
China,
South
Korea,
Australia,
strong
collaborations
At
same
time,
most-cited
papers
published
journals
impact
factors
6.0
(2021),
290
citations.
Additionally,
most
topic
high
factor
journals,
according
performed,
field.
Advanced Drug Delivery Reviews,
Journal Year:
2022,
Volume and Issue:
192, P. 114621 - 114621
Published: Nov. 17, 2022
The
past
decades
have
shown
significant
advancements
in
the
development
of
solid
tumor
treatment.
For
instance,
implementation
nanosystems
for
drug
delivery
has
led
to
a
reduction
side
effects
and
improved
region.
However,
clinical
translation
faced
challenges,
as
levels
are
still
considered
be
inadequate.
Interdisciplinary
research
resulted
more
advanced
systems.
These
coined
"smart"
due
ability
followed
actively
manipulated
order
better
control
over
local
release.
Therefore,
image-guided
can
powerful
strategy
improve
activity
at
target
site.
Being
able
visualize
inflow
administered
smart
nanosystem
within
gives
potential
determine
right
moment
apply
facilitator
initiate
Here
we
provide
an
overview
available
nanosystems,
imaging
moieties,
techniques.
We
discuss
preclinical
application
these
systems,
strength
delivery,
future
personalized
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(26), P. 6285 - 6304
Published: Jan. 1, 2024
Phototherapy,
including
photothermal
therapy
(PTT)
and
photodynamic
(PDT),
has
the
advantages
of
spatiotemporal
selectivity,
non-invasiveness,
negligible
drug
resistance.
Phototherapy
been
approved
for
treating
superficial
epidermal
tumors.
However,
its
therapeutic
efficacy
is
limited
by
hypoxic
tumor
microenvironment
highly
expressed
heat
shock
protein.
Moreover,
poor
tissue
penetration
focused
irradiation
laser
region
in
phototherapy
make
deep
tissues
metastatic
tumors
challenging.
Combination
strategies,
which
integrate
each
treatment
overcome
their
disadvantages,
can
significantly
improve
efficacy.
Recently,
many
combination
strategies
have
reported.
Our
study
summarizes
used
combining
with
other
cancer
treatments
such
as
chemotherapy,
immunotherapy,
sonodynamic
therapy,
gas
starvation
chemodynamic
therapy.
Some
research
cases
were
selected
to
analyze
effect,
delivery
platform
feature,
synergetic
anticancer
mechanisms.
additional
are
summarized
tables.
This
review
provides
strong
evidence
that
phototherapy-based
enhance
effect
compared
alone.
Additionally,
challenges
future
perspectives
associated
these
combinational
therapies
discussed.
International Journal of Nanomedicine,
Journal Year:
2021,
Volume and Issue:
Volume 16, P. 7195 - 7229
Published: Oct. 1, 2021
Carbon
quantum
dots
(CQDs)
are
an
emerging
class
of
quasi-zero-dimensional
photoluminescent
nanomaterials
with
particle
sizes
less
than
10
nm.Owing
to
their
favourable
water
dispersion,
strong
chemical
inertia,
stable
optical
performance,
and
good
biocompatibility,
CQDs
have
become
prominent
in
biomedical
fields.CQDs
can
be
fabricated
by
"top-down"
"bottom-up"
methods,
both
which
involve
oxidation,
carbonization,
pyrolysis
polymerization.The
functions
include
biological
imaging,
biosensing,
drug
delivery,
gene
carrying,
antimicrobial
photothermal
ablation
so
on,
enable
them
utilized
antitumour
applications.The
purpose
this
review
is
summarize
the
research
progress
applications
from
preparation
characterization
application
prospects.Furthermore,
challenges
opportunities
discussed
along
future
perspectives
for
precise
individual
therapy
tumours.
Life,
Journal Year:
2022,
Volume and Issue:
12(3), P. 446 - 446
Published: March 17, 2022
Lung
cancer
is
the
most
common
type
worldwide,
with
non-small
cell
lung
(NSCLC)
being
subtype.
Non-disseminated
NSCLC
mainly
treated
surgical
resection.
The
intraoperative
detection
of
can
be
challenging,
since
small
and
deeply
located
pulmonary
nodules
invisible
under
white
light.
Due
to
increasing
use
minimally
invasive
techniques,
tactile
information
often
reduced.
Therefore,
several
imaging
techniques
have
been
tested
localize
nodules,
which
near-infrared
(NIR)
fluorescence
an
emerging
modality.
In
this
systematic
review,
available
literature
on
cancers
presented,
shows
that
NIR
fluorescence-guided
surgery
has
potential
identify
tumor
during
surgery,
detect
additional
lesions
prevent
tumor-positive
resection
margins.
Langmuir,
Journal Year:
2022,
Volume and Issue:
38(4), P. 1360 - 1367
Published: Jan. 21, 2022
An
effective
accumulation
of
the
photosensitive
drugs
in
target
tissues
is
a
vital
prerequisite
for
obtaining
optimal
photodynamic
or
photothermal
treatment
effects
during
lung
cancer
treatment.
In
this
study,
porous
Fe3O4
nanoparticles
were
used
to
efficiently
load
near-infrared
drug
indocyanine
green
(ICG)
pores
(denoted
as
Fe/ICG)
by
electrostatic
adsorption.
Subsequently,
Fe/ICG
was
modified
with
hyaluronic
acid
(HA)
construct
novel
nanoprobe
Fe/ICG@HA).
Fe/ICG@HA
exhibited
not
only
excellent
ICG
loading
and
stability
but
also
significant
uptake
cells
owing
targeting
characteristics.
Meanwhile,
improved
efficiency
thermal
conversion
generation
singlet
oxygen,
thereby
resulting
an
photothermal/photodynamic
therapy
effect.
Based
on
vivo
experiments
T2-magnetic
resonance
(MR)
imaging,
confirmed
possess
tumor-targeting
abilities.
Furthermore,
under
808
nm
laser
irradiation,
therapeutic
effect
observed
tumor
growth
animal
models.
The
proposed
strategy
may
provide
functional
pathway
targeted
combined
therapy.
