Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114821 - 114821

Published: April 9, 2023

Language: Английский

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Nanotechnology for enhanced nose-to-brain drug delivery in treating neurological diseases

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 519 - 534

Published: Jan. 11, 2024

Language: Английский

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Emerging nitric oxide gas‐assisted cancer photothermal treatment

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 24, 2024

Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.

Language: Английский

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Multifunctional nanoparticles for image-guided drug delivery in nuclear medicine: advancements and applications

Journal of Radioanalytical and Nuclear Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Language: Английский

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Image-guided drug delivery: Nanoparticle and probe advances

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 206, P. 115188 - 115188

Published: Jan. 23, 2024

Language: Английский

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Camptothecin-based prodrug nanomedicines for cancer therapy

Nanoscale, Journal Year: 2023, Volume and Issue: 15(44), P. 17658 - 17697

Published: Jan. 1, 2023

Camptothecin (CPT) is a cytotoxic alkaloid that attenuates the replication of cancer cells via blocking DNA topoisomerase 1.

Language: Английский

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Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)

Published: Nov. 6, 2024

Cancer remains one of the most challenging health issues globally, demanding innovative therapeutic approaches for effective treatment. Nanoparticles, particularly those composed gold, silver, and iron oxide, have emerged as promising candidates changing cancer therapy. This comprehensive review demonstrates landscape nanoparticle-based oncological interventions, focusing on remarkable advancements potentials oxide nanoparticles. Gold nanoparticles garnered significant attention their exceptional biocompatibility, tunable surface chemistry, distinctive optical properties, rendering them ideal various diagnostic strategies. Silver nanoparticles, renowned antimicrobial exhibit potential in therapy through multiple mechanisms, including apoptosis induction, angiogenesis inhibition, drug delivery enhancement. With magnetic properties offer unique diagnosis targeted opportunities. critically examines recent synthesis, functionalization, biomedical applications these Moreover, challenges are discussed, toxicity concerns, immunogenicity, translational barriers, ongoing efforts to overcome hurdles highlighted. Finally, insights into future directions regulatory considerations, provided aiming accelerate translation technologies from bench bedside.

Language: Английский

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Advancements in manganese complex-based MRI agents: Innovations, design strategies, and future directions

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(9), P. 104101 - 104101

Published: July 16, 2024

Language: Английский

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A Comprehensive Review on Current Knowledge and Future Potential of Topical Therapies in Breast Cancer Treatment

Meme sağlığı dergisi/Meme sağlığı dergisi, Journal Year: 2025, Volume and Issue: 21(1), P. 9 - 15

Published: Jan. 2, 2025

Key Points •Topical therapies are localized treatments that target the breast tumour location specifically.• By limiting drug's exposure to rest of body, this strategy lowers possibility systemic adverse effects. •The efficacy therapy may be increased by direct application location.• These function directly targeting cancer cells through skin penetration, which can help minimise size and relieve symptoms.• To increase overall effectiveness treatment, topical frequently used in conjunction with other including radiation, surgery, or chemotherapy.

Language: Английский

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Strategies for engineering biomimetic materials for tumor therapy

Matter, Journal Year: 2025, Volume and Issue: 8(1), P. 101899 - 101899

Published: Jan. 1, 2025

Language: Английский

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