Nanophotonics,
Journal Year:
2021,
Volume and Issue:
10(12), P. 3089 - 3134
Published: Sept. 2, 2021
Abstract
Cancer
is
the
second
leading
cause
of
death
worldwide
after
cardiovascular
disease.
Depending
on
type
and
location
tumor,
several
cancer
treatments
are
implemented.
Among
these,
three
most
conventional
therapies
surgery,
radiotherapy
chemotherapy.
However,
there
other
therapeutic
approaches
such
as
photodynamic
therapy
(PDT).
PDT
relies
combined
action
light,
a
photoactivable
molecule
called
photosensitizer
(PS)
molecular
oxygen.
Most
PSs
used
for
clinical
applications
not
cancer-cell
specific.
One
solutions
to
overcome
this
problem
use
nanoparticles
(NPs)
induce
passive
targeting.
It
also
possible
graft
vector
onto
NPs
specifically
target
membrane
receptors
overexpressed
in
tumor
cells
or
neovessels
surrounding
tumor.
In
review,
we
focus
loaded
with
coupled
peptides
targeted
PDT.
We
described
nanosystems
that
Neuropilin-1
(NRP-1),
α
v
β
3
integrins,
nucleolin
receptor,
epidermal
growth
factor
(EGF)
protein-glutamine-gamma-glutamyltransferase
(TGM2),
p32,
transferrin,
PD-1,
mitochondrial
membrane.
The
cell
absorbing-peptide
described.
Royal Society Open Science,
Journal Year:
2022,
Volume and Issue:
9(4)
Published: April 1, 2022
Although
nanomedicines
have
been
in
the
oncology
field
for
almost
three
decades
with
introduction
of
doxil,
only
a
few
nanomedicine
products
reached
approval.
Can
nanotechnology
be
realistic
tool
to
reduce
number
hospital
beds?
At
present,
several
clinically
approved
anti-PD-1/PD-L1
antibodies
or
CAR
T
cell-based
therapies
are
available;
however,
immunotherapy
is
far
from
mature.
Will
fourth
pillar
cancer
treatment?
In
this
review,
we
summarized
current
status
using
PD-1/PD-L1-targeting
nanocarriers.
The
knowledge
on
material
science,
therapeutic
agents
and
formulation
designs
could
pave
way
high-efficacy
treatment
outcomes.
Smart Medicine,
Journal Year:
2023,
Volume and Issue:
2(2)
Published: March 10, 2023
Engineered
biohybrids
have
recently
emerged
as
innovative
biomimetic
platforms
for
cancer
therapeutic
applications.
Particularly,
engineered
photoresponsive
hold
tremendous
potential
against
tumors
due
to
their
intriguing
properties,
ability,
and
enhanced
biotherapeutic
functions.
In
this
review,
the
design
principles
of
latest
progresses
tumor
therapy
are
summarized.
Representative
highlighted
including
biomolecules-associated,
cell
membrane-based,
eukaryotic
cell-based,
bacteria-based,
algae-based
biohybrids.
modalities
presented,
photothermal
therapy,
photodynamic
synergistic
combined
with
tissue
regeneration.
Moreover,
challenges
future
perspectives
these
clinical
practice
discussed.
Nanophotonics,
Journal Year:
2021,
Volume and Issue:
10(12), P. 3089 - 3134
Published: Sept. 2, 2021
Abstract
Cancer
is
the
second
leading
cause
of
death
worldwide
after
cardiovascular
disease.
Depending
on
type
and
location
tumor,
several
cancer
treatments
are
implemented.
Among
these,
three
most
conventional
therapies
surgery,
radiotherapy
chemotherapy.
However,
there
other
therapeutic
approaches
such
as
photodynamic
therapy
(PDT).
PDT
relies
combined
action
light,
a
photoactivable
molecule
called
photosensitizer
(PS)
molecular
oxygen.
Most
PSs
used
for
clinical
applications
not
cancer-cell
specific.
One
solutions
to
overcome
this
problem
use
nanoparticles
(NPs)
induce
passive
targeting.
It
also
possible
graft
vector
onto
NPs
specifically
target
membrane
receptors
overexpressed
in
tumor
cells
or
neovessels
surrounding
tumor.
In
review,
we
focus
loaded
with
coupled
peptides
targeted
PDT.
We
described
nanosystems
that
Neuropilin-1
(NRP-1),
α
v
β
3
integrins,
nucleolin
receptor,
epidermal
growth
factor
(EGF)
protein-glutamine-gamma-glutamyltransferase
(TGM2),
p32,
transferrin,
PD-1,
mitochondrial
membrane.
The
cell
absorbing-peptide
described.
