Mini Review on Polymer-based Nano Enable System for Targeted Delivery of Chalcone Derivatives against Cancerous Tissues: An Effective Treatment Approach DOI
Swarupananda Mukherjee, Dipanjan Karati

Current Applied Polymer Science, Journal Year: 2023, Volume and Issue: 6(1), P. 2 - 13

Published: April 1, 2023

Abstract: Nanotechnology augmentation have enabled the creation of innovative colloidal preparations that can modify pharmacological characteristics medications. Numerous effective applications in treatment cancer been made possible by distinctive physicochemical and technological therapies based on nanomaterials. To facilitate maximize interaction between cells tissues, it is necessary to examine size, shape, charge, patterning nanoscale therapeutic molecules. The flavonoids chalcones their natural scaffolds provide a variety biological effects crucial for creating medicines. Plant-based anticancer medicines represent promising scientific business opportunity should be investigated. By using traditional Chinese medicine (TCM) therapies, diseases avoided, healthcare enhanced. Traditional safe, straightforward, reasonably priced. There are numerous treatments chronic, geriatric, incurable diseases. Heterocyclic equivalents properties. One them its anti-cancer properties, as result Chalcones drawn huge interest study malignancy. Licorice an essential primary ingredient many folk medicines, including Mongolian medicine. Research chalcone with strong growth-inhibitory activity tumor cell lines was influenced rising this medicinal molecule, papers these now accessible. It do thorough examination before congeners developed prodrug or chemical treat cancer. create focused efficient drug delivery system treatment, we shall discuss derivatives nano-enabled systems article. has discussed how polymeric nanoparticles might effectively localize particular tissues act vehicles drugs due characteristics. A strategy increase effectiveness various nanoencapsulation active substances systems.

Language: Английский

Gold Nanoparticles: Construction for Drug Delivery and Application in Cancer Immunotherapy DOI Creative Commons

Huiqun Huang,

Ronghui Liu, Jie Yang

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1868 - 1868

Published: July 2, 2023

Cancer immunotherapy is an innovative treatment strategy to enhance the ability of immune system recognize and eliminate cancer cells. However, dose limitations, low response rates, adverse events pose significant challenges. To address these gold nanoparticles (AuNPs) have been explored as immunotherapeutic drug carriers owing their stability, surface versatility, excellent optical properties. This review provides overview advanced synthesis routes for AuNPs utilization improve precision therapies. The also emphasises various aspects AuNP-based immunotherapy, including loading, targeting strategies, release mechanisms. application combined with therapeutic efficacy are briefly discussed. Overall, we aimed provide a recent understanding advances, challenges, prospects anticancer applications.

Language: Английский

Citations

79
Highly efficient upconversion photodynamic performance of rare-earth-coupled dual-photosensitizers: ultrafast experiments and excited-state calculations DOI Creative Commons

Yubiao Yang,

Lei Zhang, Chao Xiao

et al.

Nanophotonics, Journal Year: 2024, Volume and Issue: 13(4), P. 443 - 455

Published: Feb. 2, 2024

Abstract Upconversion photodynamic therapy (UC-PDT), which integrates upconversion nanoparticles (UCNPs) with photosensitizers (PSs), presents a promising advancement in the field of phototherapy. However, despite extensive studies focused on design and synthesis UCNPs, there is paucity systematic research mechanisms underlying synergistic effects. Here we have synthesized core@dotted-shell (CDSNPs) covalently tethered them two distinct PSs, thereby constructing dual-PS UC-PDT system high performance. To unravel mechanism synergism, employed combination quantum mechanical calculations ultrafast time-resolved spectroscopy techniques. The results indicate that rare earth oxides play pivotal role enhancing intersystem crossing processes PSs through modulating their excited electronic states. Additionally, Förster resonance energy transfer between contributes to amplification triplet state populations, thus further effect. In vitro experiments demonstrate prepared CDSNPs based exhibits excellent biocompatibility normal cells exceptional efficacy against tumor upon near-infrared excitation. This theoretical insights into application multi-photosensitizer systems, laying groundwork for more efficient preclinical implementations future.

Language: Английский

Citations

18
Singlet Oxygen Photophysics: From Liquid Solvents to Mammalian Cells DOI
Mikkel Bregnhøj, Frederik Thorning, Peter R. Ogilby

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(17), P. 9949 - 10051

Published: Aug. 6, 2024

Molecular oxygen, O

Language: Английский

Citations

12
The Photosensitizer Temoporfin (mTHPC) – Chemical, Pre‐clinical and Clinical Developments in the Last Decade†‡ DOI Creative Commons
Arno Wiehe, Mathias O. Senge

Photochemistry and Photobiology, Journal Year: 2022, Volume and Issue: 99(2), P. 356 - 419

Published: Sept. 26, 2022

Abstract This review follows the research, development and clinical applications of photosensitizer 5,10,15,20‐tetra( m ‐hydroxyphenyl)chlorin ( THPC, temoporfin) in photodynamic (cancer) therapy (PDT) other medical applications. Temoporfin is active substance medicinal product Foscan® authorized EU for palliative treatment head neck cancer. Chemistry, biochemistry pharmacology, as well temoporfin are addressed, including extensive work that has been done on formulation liposomal formulations. The literature covered from 2009 to early 2022, thereby connecting it previous this published journal [Senge, M. O. J. C. Brandt (2011) Photochem. Photobiol. 87, 1240–1296] which followed its way initial approval application.

Language: Английский

Citations

33
A Photosensitized Singlet Oxygen (1O2) Toolbox for Bio-Organic Applications: Tailoring 1O2 Generation for DNA and Protein Labelling, Targeting and Biosensing DOI Creative Commons
Dorien Aerssens, Enrico Cadoni, Laure Tack

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(3), P. 778 - 778

Published: Jan. 25, 2022

Singlet oxygen (1O2) is the excited state of ground, triplet state, molecular (O2). Photosensitized 1O2 has been extensively studied as one reactive species (ROS), responsible for damage cellular components (protein, DNA, lipids). On other hand, its generation exploited in organic synthesis, well photodynamic therapy treatment various forms cancer. The aim this review to highlight versatility 1O2, discussing main bioorganic applications reported over past decades, which rely on production. After a brief introduction photosensitized production we will describe aspects involving biologically relevant that can accompany an uncontrolled, aspecific ROS. We then discuss more detail series biological featuring generation, including protein and DNA labelling, cross-linking biosensing. Finally, methodologies available tailor order accomplish proposed transformations while avoiding, at same time, collateral related untamed species.

Language: Английский

Citations

26
Advances in Radionuclides and Radiolabelled Peptides for Cancer Therapeutics DOI Creative Commons
Kushal Chakraborty, Jagannath Mondal,

Jeong Man An

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 971 - 971

Published: March 17, 2023

Radiopharmaceutical therapy, which can detect and treat tumours simultaneously, was introduced more than 80 years ago, it has changed medical strategies with respect to cancer. Many radioactive radionuclides have been developed, functional, molecularly modified radiolabelled peptides used produce biomolecules therapeutics that are vastly utilised in the field of radio medicine. Since 1990s, they smoothly transitioned into clinical application, as today, a wide variety radionuclide derivatives examined evaluated various studies. Advanced technologies, such conjugation functional or incorporation chelating ligands, developed for advanced radiopharmaceutical cancer therapy. New conjugates targeted radiotherapy designed deliver radiation directly cells improved specificity minimal damage surrounding normal tissue. The development new theragnostic radionuclides, be both imaging therapy purposes, allows precise targeting monitoring treatment response. increased use peptide receptor (PRRT) is also important specific receptors overexpressed cells. In this review, we provide insights peptides, give brief background, describe their transition application.

Language: Английский

Citations

16
Unlocking the Potential of RGD-Conjugated Gold Nanoparticles: A New Frontier in Targeted Cancer Therapy, Imaging, and Metastasis Inhibition DOI
Hossein Javid, Mahsa Akbari Oryani,

Nastaran Rezagholinejad

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(42), P. 10786 - 10817

Published: Jan. 1, 2024

The review highlights the potential of RGD-conjugated AuNPs in cancer diagnosis and treatment, including breast cancer. It emphasizes need for further research to fully realize this technology’s inspire future investigations.

Language: Английский

Citations

5
Design and synthesis of bioinspired nanomaterials for biomedical application DOI
Kai Tang,

Jianmin Xue,

Yufang Zhu

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2023, Volume and Issue: 16(1)

Published: July 2, 2023

Abstract Natural materials and bioprocesses provide abundant inspirations for the design synthesis of high‐performance nanomaterials. In past several decades, bioinspired nanomaterials have shown great potential in application biomedical fields, such as tissue engineering, drug delivery, cancer therapy, so on. this review, three types strategies nanomaterials, that is, inspired by natural structures, biomolecules, bioprocesses, are mainly introduced. We summarize discuss concepts approaches various along with their specific roles applications. Additionally, we challenges development mechanical failure wet environment, limitation scale‐up fabrication, lack deep understanding biological properties. It is expected clinical translation will be further promoted under cooperation interdisciplinary subjects future. This article categorized under: Implantable Materials Surgical Technologies > Nanomaterials Implants Therapeutic Approaches Drug Discovery Emerging

Language: Английский

Citations

13
Multifunctional Copper Complex-Mediated Self-Blocking Plasmid Delivery of Pd-L1 for Tumor Chemoimmunotherapy DOI

Huang Xiaoya,

Jiaqi Xu,

Zhou Fang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Added Value of Scintillating Element in Cerenkov-Induced Photodynamic Therapy DOI Creative Commons
Perrine Schneller, Charlotte Collet, Quentin Béen

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(2), P. 143 - 143

Published: Jan. 18, 2023

Cerenkov-induced photodynamic therapy (CR-PDT) with the use of Gallium-68 (68Ga) as an unsealed radioactive source has been proposed alternative strategy to X-ray-induced (X-PDT). This new still aims produce a effect nanoparticles, namely, AGuIX. Recently, we replaced Gd from AGuIX@ platform Terbium (Tb) nanoscintillator and added 5-(4-carboxyphenyl succinimide ester)-10,15,20-triphenylporphyrin (P1) photosensitizer (referred AGuIX@Tb-P1). Although Cerenkov luminescence 68Ga positrons is involved in activation, cytotoxic obtained by PDT remains controversial. Herein, tested whether free could substitute X-rays X-PDT obtain phototherapeutic effect. Results were compared those AGuIX@Gd-P1 nanoparticles. We showed, Monte Carlo simulations, contribution Tb scintillation P1 activation energy transfer between after radiation, Gd-based confirmed involvement type II reaction during 68Ga-mediated luminescence, id est, photon AGuIX@Tb-P1 which, turn, generated P1-mediated singlet oxygen. The on cell survival was studied clonogenic assays using human glioblastoma U-251 MG cells. Exposure pre-treated cells resulted decrease clone formation, unlike AGuIX@Gd-P1. conclude that CR-PDT be X-PDT.

Language: Английский

Citations

5