Journal of Materials Research and Technology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159986 - 159986
Published: Jan. 1, 2025
Citations
2
Processes, Journal Year: 2023, Volume and Issue: 11(9), P. 2696 - 2696
Published: Sept. 8, 2023
Biomaterials are mostly any natural and synthetic materials which compatible from a biological point of view with the human body. widely used to sustain, increase, reestablish or substitute function injured tissue organ Additionally, biomaterials uninterruptedly in contact body, i.e., tissue, blood fluids. For this reason, an essential feature is their biocompatibility. Consequently, review summarizes classification different types based on origin, as ones. Moreover, advanced applications pharmaceutical medical domains highlighted specific mechanical physical properties biomaterials, concerning use. The high-priority challenges field also discussed, especially those regarding transfer implementation valuable scientific results practice.
Language: Английский
Citations
35
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2660 - 2660
Published: Jan. 31, 2023
Bone tissue engineering (BTE) utilizes a special mix of scaffolds, cells, and bioactive factors to regulate the microenvironment bone regeneration form three-dimensional simulation structure regenerate tissue. Silk fibroin (SF) is perhaps most encouraging material for BTE given its tunable mechanical properties, controllable biodegradability, excellent biocompatibility. Numerous studies have confirmed significance SF stimulating formation. In this review, we start by introducing characteristics SF. After that, immunological mechanism osteogenesis summarized, various forms biomaterials latest development prospects in are emphatically introduced. Biomaterials based on great potential engineering, review will serve as resource future design research.
Language: Английский
Citations
28
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 355 - 355
Published: Jan. 20, 2023
Microneedles are a patient-friendly technique for delivering drugs to the site of action in place traditional oral and injectable administration. Silk fibroin represents an interesting polymeric biomaterial because its mechanical properties, thermal stability, biocompatibility possibility control via genetic engineering. This review focuses on critical research progress silk microneedles since their inception, analyzes detail structure properties fibroin, types microneedles, drug delivery applications clinical trials, summarizes future development trend this field. It also proposes direction including increasing loading doses enriching as well exploring with stimulation-responsive release functions. The safety effectiveness should be further verified trials at different stages.
Language: Английский
Citations
23
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105689 - 105689
Published: April 21, 2024
In the last few years, wound healing and development of "ideal" biomaterials that provide quick recovery minimize scarring have represented one most important priorities researchers. this direction, silk fibroin (SF) scaffolds gained substantial awareness, as a promising polymer owing to their increased biocompatibility, outstanding mechanical properties, biodegradability, especially tensile strength. Furthermore, SF is acknowledged accelerate process by encouraging cell growth proliferation, also migration different types cells are included in stages process. Therefore, metal oxide nanoparticles (NPs), such iron (FeO), copper (CuO), zinc (ZnO), or magnesium (MgO) NPs, been extensively researched for antimicrobial properties ability enhance tissue regeneration addition SF. When introduced within scaffolds, these NPs impart enhanced including improved scaffold stability durability. Moreover, presence could increase biocompatibility facilitating adhesion, migration, ultimately promoting processes. The incorporation other natural polymers into has thus emerged favorable method therapeutic potential developed biomaterial. This review aims an overview advancements containing applications.
Language: Английский
Citations
14
Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(4), P. 2323 - 2337
Published: March 4, 2024
Genipin-cross-linked silk fibroin (SF) hydrogel is considered to be biocompatible and mechanically robust. However, its use remains a challenge for
Language: Английский
Citations
10
Gels, Journal Year: 2023, Volume and Issue: 9(10), P. 806 - 806
Published: Oct. 7, 2023
Polymeric hydrogels are a complex class of materials with one common feature—the ability to form three-dimensional networks capable imbibing large amounts water or biological fluids without being dissolved, acting as self-sustained containers for various purposes, including pharmaceutical and biomedical applications. Transdermal microneedles pain-free drug delivery system that continues on the path widespread adoption—regulatory guidelines horizon, investments in field continue grow annually. Recently, have generated interest transdermal due their tunable properties, allowing them be exploited systems extraction tools. As hydrogel new emerging technology, fabrication faces challenges must resolved redeem themselves viable option. This article discusses from material perspective, regardless mechanism action. It cites recent advances formulation, presents relevant characterization methods, manufacturing regulatory facing these technologies before approval.
Language: Английский
Citations
17
Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(3), P. 686 - 712
Published: April 2, 2024
Language: Английский
Citations
8
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(28)
Published: July 15, 2024
3D in vitro model has emerged as a valuable tool for studying tissue development, drug screening, and disease modeling. systems can accurately replicate microstructures physiological features, mirroring the vivo microenvironment departing from conventional 2D cell cultures. Various models utilizing biomacromolecules like collagen synthetic polymers have been developed to meet diverse research needs address complex challenges of contemporary research. Silk proteins, bearing structural functional similarities collagen, increasingly employed construct advanced systems, surpassing limitations This review examines silk proteins' composition, structure, properties, functions, elucidating their role models. Furthermore, recent advances biomedical applications involving silk-based organoid are discussed. In particular, unique attributes matrix constituents constructs highlighted, providing meticulous evaluation importance. Additionally, it outlines current hurdles complexities while contemplating future avenues, thereby paving way developing biomimetic protein-based microtissues.
Language: Английский
Citations
8
SusMat, Journal Year: 2024, Volume and Issue: 4(3)
Published: May 27, 2024
Abstract Spider silk, possessing exceptional combination properties, is classified as a bio‐gel fiber. Thereby, it serves valuable origin of inspiration for the advancement various artificial gel fiber materials with distinct functionalities. Gel fibers exhibit promising potential utilization in diverse fields, including smart textiles, muscle, tissue engineering, and strain sensing. However, there are still numerous challenges improving performance functionalizing applications spider silk‐inspired fibers. Thus, to gain penetrating insight into bioinspired fibers, this review provided comprehensive overview encompassing three key aspects: fundamental design concepts implementing strategies properties strengthening functionalities application prospects In particular, multiple toughening mechanisms were introduced at micro, nano, molecular‐level structures Additionally, existing summarized. This aims offer significant guidance development inspire further research field high‐performance
Language: Английский
Citations
6