ACS Materials Au,
Journal Year:
2024,
Volume and Issue:
5(1), P. 115 - 140
Published: Nov. 28, 2024
The
delivery
of
molecules,
such
as
DNA,
RNA,
peptides,
and
certain
hydrophilic
drugs,
across
the
epidermal
barrier
poses
a
significant
obstacle.
Microneedle
technology
has
emerged
prominent
area
focus
in
biomedical
research
because
its
ability
to
deliver
wide
range
biomolecules,
vaccines,
medicines,
other
substances
through
skin.
Microneedles
(MNs)
form
microchannels
by
disrupting
skin's
structure,
which
compromises
function,
facilitating
easy
penetration
drugs
into
These
devices
enhance
administration
many
therapeutic
skin,
enhancing
their
stability.
Transcutaneous
medications
using
microneedle
patch
offers
advantages
over
conventional
drug
methods.
containing
active
can
be
stimulated
different
internal
external
factors
result
regulated
release
substances.
To
achieve
efficient
desired
location,
it
is
necessary
consider
design
needles
with
appropriate
optimized
characteristics.
choice
materials
for
developing
manufacturing
these
vital
determining
pharmacodynamics
pharmacokinetics
delivery.
This
article
provides
most
recent
update
overview
numerous
systems
that
utilize
activators
stimulate
components
from
microneedles.
Further,
discusses
utilized
producing
microneedles
strategies
important
managing
drugs.
An
explanation
commonly
employed
fabrication
techniques
applications
electronics,
particularly
integrated
systems,
discussed.
successfully
implement
clinical
settings,
essential
comprehensively
assess
several
factors,
biocompatibility,
stability,
safety,
production
cost.
Finally,
an
in-depth
review
criteria
difficulties
potential
future
direction
delivering
monitoring
diseases
explored.
Molecular Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Microneedles
(MNs)
are
emerging
as
versatile
tools
for
both
therapeutic
drug
delivery
and
diagnostic
monitoring.
Unlike
hypodermic
needles,
MNs
achieve
these
applications
with
minimal
or
no
pain
customizable
designs,
making
them
suitable
personalized
medicine.
Understanding
the
key
design
parameters
challenges
during
contact
biofluids
is
crucial
to
optimizing
their
use
across
applications.
This
review
summarizes
current
fabrication
techniques
considerations
tailored
meet
distinct
requirements
biosensing
We
further
underscore
state
of
theranostic
that
integrate
propose
future
directions
advancing
toward
clinical
use.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 4321 - 4337
Published: May 1, 2024
Cannabidiol
(CBD)
is
a
promising
therapeutic
drug
with
low
addictive
potential
and
favorable
safety
profile.
However,
CBD
did
face
certain
challenges,
including
poor
solubility
in
water
oral
bioavailability.
To
harness
the
of
by
combining
it
transdermal
delivery
system
(TDDS).
This
innovative
approach
sought
to
develop
patch
dosage
form
micellar
vesicular
nanocarriers
enhance
bioavailability
CBD,
leading
improved
outcomes.
Biofabrication,
Journal Year:
2024,
Volume and Issue:
16(4), P. 042005 - 042005
Published: Aug. 9, 2024
The
global
demand
for
an
enhanced
quality
of
life
and
extended
lifespan
has
driven
significant
advancements
in
tissue
engineering
regenerative
medicine.
These
fields
utilize
a
range
interdisciplinary
theories
techniques
to
repair
structurally
impaired
or
damaged
tissues
organs,
as
well
restore
their
normal
functions.
Nevertheless,
the
clinical
efficacy
medications,
materials,
potent
cells
used
at
laboratory
level
is
always
constrained
by
technological
limitations.
A
novel
platform
known
adaptable
microneedles
been
developed
address
abovementioned
issues.
offer
solution
localized
distribution
various
cargos
while
minimizing
invasiveness.
Microneedles
provide
favorable
patient
compliance
settings
due
effective
administration
ability
painless
convenient
process.
In
this
review
article,
we
summarized
most
recent
development
microneedles,
started
classifying
microneedle
systems,
advantages,
fundamental
properties.
Subsequently,
it
provides
comprehensive
overview
different
types
material
fabricate
properties
ideal
applications
medicine,
primarily
focusing
on
preserving
restoring
organs.
limitations
perspectives
have
discussed
concluding
future
therapeutic
medicines.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(7), P. 4254 - 4269
Published: June 12, 2024
The
skin,
being
the
largest
organ
of
human
body,
is
susceptible
to
damage
resulting
in
wounds
that
are
vulnerable
pathogenic
attacks
and
fail
provide
effective
protection
for
internal
tissues.
Therefore,
it
crucial
expedite
wound
healing.
In
recent
years,
microneedles
have
garnered
significant
attention
as
an
innovative
drug
delivery
system
owing
their
noninvasive
painless
administration,
simplified
application
process,
precise
control
over
release,
versatile
loading
capabilities.
Consequently,
they
hold
immense
potential
treatment
skin
wound.
This
review
presents
a
comprehensive
design
strategy
microneedle
promoting
First,
process
healing
characteristics
specific
elucidated.
strategies
subsequently
presented
classified
based
on
structural
therapeutic
methodologies.
Finally,
succinct
recapitulation
previously
discussed
points
prospective
analysis
provided.
Small Structures,
Journal Year:
2024,
Volume and Issue:
5(12)
Published: Aug. 14, 2024
Microneedles
hold
remarkable
potential
for
providing
convenient
and
unique
solutions
disease
diagnosis
therapy.
However,
their
integration
into
clinical
practices
has
been
slow,
primarily
due
to
the
challenge
of
developing
models
that
meet
criteria
a
particular
application.
A
comprehensive
systematic
analysis
all
aspects
microneedle
platforms
is
imperative
overcome
this
bottleneck.
The
involves
gathering
performance‐related
information
understanding
factors
affecting
functionality
microneedles.
performance
microneedles
heavily
influenced
by
parameters
such
as
dimensions,
needle
shape,
array
arrangement,
materials
(flexible,
stretchable,
stimuli‐responsive,
biodegradable).
This
article
presents
fresh
perspective
on
microneedles,
introducing
concepts
toward
optimal
designs
across
various
platforms.
includes
application,
design,
fabrication
techniques,
how
specific
design
can
effectively
requirements
By
addressing
these
crucial
issues,
further
advancement
technology
occurs.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(18), P. 2568 - 2568
Published: Sept. 11, 2024
Our
comprehensive
review
plunges
into
the
cutting-edge
advancements
of
polymeric
microneedle
drug
delivery
systems,
underscoring
their
transformative
potential
in
realm
transdermal
administration.
scrutiny
centers
on
substrate
materials
pivotal
for
construction
and
core
properties
that
dictate
efficacy.
We
delve
distinctive
interplay
between
microneedles
dermal
layers,
mechanisms
by
which
this
synergy
enhances
absorption
precision
targeting.
Moreover,
we
examine
acupoint-target
organ-ganglion
nexus,
an
innovative
strategy
steers
concentration
to
specific
targets,
offering
a
paradigm
medicine.
A
thorough
analysis
clinical
applications
systems
is
presented,
highlighting
adaptability
impact
across
spectrum
therapeutic
domains.
This
also
accentuates
systems'
promise
bolster
patient
compliance,
attributed
minimally
invasive
painless
mode
delivery.
present
forward-looking
strategies
aimed
at
optimizing
stimulation
sites
amplify
benefits.
The
anticipation
set
introduction
superior
biocompatible
with
advanced
mechanical
properties,
customizing
cater
specialized
demands.
In
parallel,
deliberate
safety
boosting
loading
capacities
solidifying
efficacy
microneedle-based
therapeutics.
summation,
role
technology
contemporary
healthcare,
charting
course
future
investigative
endeavors
developmental
strides
within
burgeoning
field.
