A Modified Polydopamine Nanoparticle Loaded with Melatonin for Synergistic ROS Scavenging and Anti‐Inflammatory Effects in the Treatment of Dry Eye Disease DOI Open Access

Xue Yang,

Bowen Wang, Hao Zeng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Dry eye disease (DED) is a multifaceted ocular surface disorder that significantly impacts patients’ daily lives and imposes substantial economic burden on society. Oxidative stress, induced by the overproduction of reactive oxygen species (ROS), critical factor perpetuating inflammatory cycle in DED. Effectively scavenging ROS essential to impede progression In this study, boronophenylalanine‐ containing polydopamine (PDA‐PBA) nanoparticles are developed loaded with melatonin (MT), which blended poly(vinyl alcohol) (PVA) create drops PVA/ PDA‐PBA@MT (PPP@MT). vitro vivo studies demonstrate PPP@MT exhibits dual functionalities reducing production downregulating pathways, thereby preserving mitochondrial integrity further inhibiting programmed cell death. Following treatment, tear secretion, corneal structure, number goblet cells markedly restored mouse model dry eye, indicating therapeutic efficacy agent. Collectively, PPP@MT, characterized minimal side effects favorable bioavailability, offers promising insights for management DED other ROS‐mediated disorders.

Language: Английский

The Influence of Gut Microbiota on Oxidative Stress and the Immune System DOI Creative Commons

C Kunst,

Stephan Schmid,

M Michalski

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1388 - 1388

Published: May 8, 2023

The human gastrointestinal tract is home to a complex microbial community that plays an important role in the general well-being of entire organism. gut microbiota generates variety metabolites and thereby regulates many biological processes, such as regulation immune system. In gut, bacteria are direct contact with host. major challenge here prevent unwanted inflammatory reactions on one hand other ensure system can be activated when pathogens invade. Here REDOX equilibrium utmost importance. This controlled by either directly or indirectly via bacterial-derived metabolites. A balanced microbiome sorts for stable balance, whereas dysbiosis destabilizes this equilibrium. An imbalanced status affects disrupting intracellular signaling promoting responses. we (i) focus most common reactive oxygen species (ROS) (ii) define transition from state oxidative stress. Further, (iii) describe ROS regulating Thereafter, (iv) examine influence homeostasis how shifts pro- anti-oxidative cellular conditions suppress promote responses inflammation.

Language: Английский

Citations

78
Nanomaterials in the Wound Healing Process: New Insights and Advancements DOI Creative Commons
Tanikan Sangnim, Vivek Puri, Divya Dheer

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 300 - 300

Published: Feb. 21, 2024

Wounds, which are becoming more common as a result of traumas, surgery, burns, and chronic illnesses like diabetes, remain critical medical problem. Infectious bacteria impact the healing process, particularly if its biofilm (biological films) leads to prolonged effect. Nanomaterials have emerged promising candidates in field wound due their unique properties versatile applications. New insights into interactions between nanomaterials microenvironments shed light on mechanisms underlying therapeutic effects. However, significantly minimal amount research has been carried out see these promote process. In this review, we provided an outline various types that studied for wounds infection prevention. Overall, utilization holds great promise continues evolve, providing new opportunities development effective efficient care therapies.

Language: Английский

Citations

23
Oral Nanomedicine: Challenges and Opportunities DOI

Bo Deng,

Shaomin Liu, Ying Wang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(6)

Published: Sept. 19, 2023

Abstract Compared to injection administration, oral administration is free of discomfort, wound infection, and complications has a higher compliance rate for patients with diverse diseases. However, reduces the bioavailability medicines, especially biologics (e.g., peptides, proteins, antibodies), due harsh gastrointestinal biological barriers. In this context, development prosperity nanotechnology have helped improve bioactivity availability medicines. On basis, first, barriers are discussed, then nanomedicine based on organic inorganic nanomaterials their biomedical applications in diseases reviewed. Finally, challenges potential opportunities future nanomedicine, which may provide vital reference eventual clinical transformation standardized production put forward.

Language: Английский

Citations

31
Recent progress on engineered micro/nanomaterials mediated modulation of gut microbiota for treating inflammatory bowel disease DOI

Lingling Kan,

Ziwen Zheng,

Wanyue Fu

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 43 - 65

Published: April 17, 2024

Language: Английский

Citations

14
Inhibiting the cGAS-STING Pathway in Ulcerative Colitis with Programmable Micelles DOI
Saji Uthaman,

Shadi Parvinroo,

Ansuja Pulickal Mathew

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12117 - 12133

Published: April 22, 2024

Ulcerative colitis is a chronic condition in which dysregulated immune response contributes to the acute intestinal inflammation of colon. Current clinical therapies often exhibit limited efficacy and undesirable side effects. Here, programmable nanomicelles were designed for treatment loaded with RU.521, an inhibitor cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) pathway. STING-inhibiting micelles (SIMs) comprise hyaluronic acid-stearic acid conjugates include reactive oxygen species (ROS)-responsive thioketal linker. SIMs selectively accumulate at site trigger drug release presence ROS. Our vitro studies macrophages vivo murine model demonstrated that leverage HA-CD44 binding target sites inflammation. Oral delivery mice both preventive delayed therapeutic models ameliorated colitis's severity by reducing STING expression, suppressing secretion proinflammatory cytokines, enabling bodyweight recovery, protecting from colon shortening, restoring colonic epithelium. In end points combined metabolomics identified key metabolites role mucosal findings highlight significance platforms downregulate inflammatory pathways mucosa managing bowel diseases.

Language: Английский

Citations

14
Dual‐ROS Sensitive Moieties Conjugate Inhibits Curcumin Oxidative Degradation for Colitis Precise Therapy DOI

Dunsheng Liang,

Xiaofan Shen,

Lu Han

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: March 3, 2024

Abstract Curcumin, a natural bioactive polyphenol with diverse molecular targets, is well known for its anti‐oxidation and anti‐inflammatory potential. However, curcumin exhibits low solubility (<1 µg mL −1 ), poor tissue‐targeting ability, rapid oxidative degradation, resulting in bioavailability stability inflammatory therapy. Here, poly(diselenide‐oxalate‐curcumin) nanoparticle (SeOC‐NP) dual‐reactive oxygen species (ROS) sensitive chemical moieties (diselenide peroxalate ester bonds) fabricated by one‐step synthetic strategy. The results confirmed that dual‐ROS endowed SeOC‐NP the ability of targeted delivery significantly suppress degradation high‐efficiency In detail, amount SeOC about 4‐fold lower than free an microenvironment. As result, enhanced antioxidant activity efficacy vitro analysis scavenging intracellular ROS suppressing secretion nitric oxide pro‐inflammatory cytokines. mouse colitis models, orally administered can remarkably alleviate symptoms IBD maintain homeostasis gut microbiota. This work provided simple effective strategy to fabricate ROS‐responsive micellar enhance oxidation medicine precise therapeutic inflammation.

Language: Английский

Citations

11
Simultaneous Biofilm Disruption, Bacterial Killing, and Inflammation Elimination for Wound Treatment Using Silver Embellished Polydopamine Nanoplatform DOI
Meng Ding, Yu Zhang, Xiaoye Li

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 10, 2024

Abstract Due to the presence of spatial barriers, persistent bacteria, and excessive inflammation in bacteria biofilm‐infected wounds, current nanoplatforms cannot effectively address these issues simultaneously during therapeutic process. Herein, a novel biomimetic photothermal nanoplatform integrating silver polydopamine nanoparticles (Ag/PDAs) that can damage biofilms, kill bacterial persisters, reduce for wound treatment is presented. These findings reveal Ag/PDAs exhibit broad‐spectrum antimicrobial activity through direct membrane structure. Additionally, demonstrate potent conversion efficiency. When combined with near‐infrared (NIR) irradiation, disrupt structure biofilms synergistically eradicate resident bacteria. Furthermore, show remarkable anti‐inflammatory properties counteracting bacterium‐induced macrophage polarization. The vivo results confirm topical application significantly suppress Staphylococcus aureus wounds murine models, concurrently facilitating healing. This research provides promising avenue eradication wounds.

Language: Английский

Citations

11
Microbial-Derived Antioxidants in Intestinal Inflammation: A Systematic Review of Their Therapeutic Potential DOI Creative Commons
María José Mansilla, María Jesús Rodríguez‐Sojo,

Andreea Roxana Lista

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 321 - 321

Published: March 6, 2025

The potential of microbial-derived antioxidants to modulate intestinal inflammation is increasingly recognized, which especially important in inflammatory bowel diseases (IBD). Oxidative stress, a major contributor chronic inflammation, the result an imbalance between production reactive oxygen species (ROS) and body's antioxidant defenses. This systematic review explores role alleviating IBD. Among main findings are certain compounds, such as exopolysaccharides (EPS) short-chain fatty acids (SCFAs), have demonstrated their ability neutralize ROS strengthen integrity barrier, thereby attenuating responses. These offer dual benefit mitigating oxidative stress rebalancing gut microbiota, often disrupted Evidence from preclinical clinical studies provides better understanding mechanisms involved effects these microbial antioxidants. Conventional treatments for IBD primarily focus on immune modulation. In this context, integration could complementary approach by addressing both damage dysbiosis. Further research trials essential establish standardized treatment guidelines clarify long-term efficacy promising therapeutic agents.

Language: Английский

Citations

1
Gut Microbiota Serves as a Crucial Independent Biomarker in Inflammatory Bowel Disease (IBD) DOI Open Access
Bharti Sharma,

George Agriantonis,

Kate Twelker

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2503 - 2503

Published: March 11, 2025

Inflammatory bowel disease (IBD), encompassing Crohn’s (CD), ulcerative colitis (UC), and IBD unclassified (IBD-U), is a complex intestinal disorder influenced by genetic, environmental, microbial factors. Recent evidence highlights the gut microbiota as pivotal biomarker modulator in pathogenesis. Dysbiosis, characterized reduced diversity altered composition, hallmark of IBD. A consistent decrease anti-inflammatory bacteria, such Faecalibacterium prausnitzii, an increase pro-inflammatory species, including Escherichia coli, have been observed. Metabolomic studies reveal decreased short-chain fatty acids (SCFAs) secondary bile acids, critical for homeostasis, alongside elevated metabolites. The interacts with host immune pathways, influencing morphogens, glycosylation, podoplanin (PDPN) expression. disruption glycosylation impairs mucosal barriers, while aberrant PDPN activity exacerbates inflammation. Additionally, alterations contribute to oxidative stress, further destabilizing barriers. These molecular cellular disruptions underscore role microbiome pathophysiology. Emerging therapeutic strategies, probiotics, prebiotics, dietary interventions, aim restore balance mitigate Advanced on microbiota-targeted therapies their potential reduce severity improve patient outcomes. Nevertheless, research needed elucidate bidirectional interactions between responses translate these insights into clinical applications. This review consolidates current findings microbiota’s IBD, emphasizing its diagnostic implications, advocates continued exploration microbiome-based interventions combat this debilitating disease.

Language: Английский

Citations

1
Plant-inspired visible-light-driven bioenergetic hydrogels for chronic wound healing DOI Creative Commons
Yuping Jiang,

Xiaomin Feng,

Xin Qiao

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 523 - 536

Published: Aug. 10, 2024

Language: Английский

Citations

8