ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(49), P. 67028 - 67044
Published: March 18, 2024
Bacterial
infection
and
insufficient
osteogenic
activity
are
the
main
causes
of
orthopedic
implant
failure.
Conventional
surface
modification
methods
difficult
to
meet
requirements
for
long-term
placement.
In
order
better
regulate
function
surfaces,
especially
improve
both
antibacterial
activity,
external
stimuli-responsive
(ESR)
strategies
have
been
employed
implants.
External
stimuli
act
as
"smart
switches"
interactions
with
bacteria
cells.
The
balance
between
capabilities
surfaces
can
be
achieved
through
these
specific
ESR
manifestations,
including
temperature
changes,
reactive
oxygen
species
production,
controlled
release
bioactive
molecules,
functional
ions,
etc.
This
Review
summarizes
recent
progress
on
different
(based
light,
ultrasound,
electric,
magnetic
fields)
that
effectively
performance
capability
Furthermore,
current
limitations
challenges
implants
well
future
development
direction
also
discussed.
Chemical Engineering Journal,
Journal Year:
2024,
Volume and Issue:
487, P. 150403 - 150403
Published: March 16, 2024
Hydrogels
have
emerged
in
various
biomedical
applications,
including
tissue
engineering
and
medical
devices,
due
to
their
ability
imitate
the
natural
extracellular
matrix
(ECM)
of
tissues.
However,
conventional
static
hydrogels
lack
dynamically
respond
changes
surroundings
withstand
robust
biophysical
microenvironment
trigger
on-demand
functionality
such
as
drug
release
mechanical
change.
In
contrast,
multifunctional
dynamic
can
adapt
external
stimuli
drawn
great
attention
recent
studies.
It
is
realized
that
integration
nanomaterials
into
provides
numerous
functionalities
for
a
variety
applications
cannot
be
achieved
by
hydrogels.
This
review
article
comprehensive
overview
advances
designing
fabricating
applications.
We
describe
different
types
based
on
breakable
reversible
covalent
bonds
well
noncovalent
interactions.
These
mechanisms
are
described
detail
useful
reference
crosslinking
strategies
strongly
influence
properties
also
discuss
use
potential
benefits.
further
explores
nanocomposite
hydrogels,
delivery,
engineering,
bioadhesives,
wound
healing,
cancer
treatment,
mechanistic
study,
multiple-scale
Finally,
we
challenges
future
perspectives
field
diverse
technologies.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(38)
Published: April 23, 2024
Abstract
Currently,
microbial
infections
have
posed
an
arduous
challenge
to
global
public
health,
whereas
the
rise
of
antibiotic
resistance
is
rendering
traditional
therapies
futile,
prompting
development
new
antimicrobial
technologies.
Photoactive
nanomaterials
thus
garnered
a
thriving
interest
for
disinfection
owing
their
superior
antibacterial
efficaciousness,
favorable
biosafety,
and
rapidness
spatiotemporal
precision
in
excreting
bactericidal
actions.
The
review
summarizes
recent
advances
emerging
trends
design,
nanoengineering,
bioapplications
photoactive
antimicrobials.
It
commences
by
elaborating
fundamental
theories
on
bacterial
resistance,
mechanisms
phototherapy.
Subsequently,
regulation
effectiveness
comprehensively
discussed,
centering
criteria
strategies
tuning
photoabsorption
spectra,
photothermal
conversion,
photocatalytic
efficiency,
alongside
tactics
enabling
synergistic
therapies.
This
followed
comparative
analyses
techniques
modalities
synthesizing
engineering
with
diverse
structures,
forms,
functionalities.
Thereafter,
state‐of‐the‐art
applications
phototherapies
across
various
medical
sectors
are
portrayed,
key
challenges
opportunities
finally
discussed
spur
future
innovations
translation.
envisaged
provide
useful
guidance
devising
developing
nanomaterials‐based
photoresponsive
antimicrobials
application‐specific
materials
properties
biological
functions.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(22)
Published: May 27, 2024
Infected
wounds
pose
challenges
such
as
exudate
management,
bacterial
infections,
and
persistent
inflammation,
making
them
a
significant
challenge
for
modern
dressings.
To
address
these
issues
in
infected
more
effectively,
aerogel-hydrogel
biphase
gels
based
on
dextran
are
developed.
The
gel
introduced
this
study
exhibits
antibacterial
anti-inflammatory
properties
the
process
of
wound
therapy,
contributing
to
accelerated
healing.
aerogel
phase
exceptional
water-absorption
capabilities,
rapidly
soaking
up
from
wound,
thereby
fostering
clean
hygienic
healing
microenvironment.
Concurrently,
is
enriched
with
hydrogen
sulfide
donors.
Following
water
absorption
formation
hydrogel
phase,
it
enables
sustained
release
around
sites.
experiments
confirm
that
sulfide,
by
promoting
M2
macrophage
differentiation
reducing
levels
inflammatory
factors,
effectively
diminishes
local
inflammation
at
site.
Furthermore,
sodium
copper
chlorophyllin
component
within
demonstrates
effective
through
photodynamic
antimicrobial
providing
viable
solution
infection
challenges.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(2), P. 819 - 828
Published: Jan. 22, 2024
The
combinational
properties
with
excellent
mechanical
properties,
adhesive
performance,
hemostatic
ability,
antibacterial
action,
and
wound
healing
efficacy
are
highly
desirable
for
injectable
hydrogels'
practical
applications
in
hemorrhage
control
closure,
but
designing
one
single
hydrogel
system
integrating
such
is
still
difficult.
Herein,
a
simplified
yet
straightforward
strategy
proposed
to
prepare
an
robust
poly(N,N-dimethylacrylamide)
(PDMAA)/carboxymethyl
chitosan
(CMCS)
induced
by
tranexamic
acid
(TXA).
TXA
not
only
promotes
the
rapid
generation
of
free
radicals
also
introduces
multiple
hydrogen
bonds
into
network.
Moreover,
as
common
clinical
drug,
itself
has
effects.
In
addition,
CMCS
imparts
sterilization
hemostasis
effects
hydrogel,
thereby
promoting
healing.
Besides,
amino
carboxyl
groups
on
molecules
hydroxyl,
amino,
can
form
wet
biological
tissues,
leading
good
tissue
adhesion
hydrogel.
As
result,
(up
1.83
MPa
at
90%
compression
strain),
performance
18.7
kPa
strength
porcine
skin
tissue),
biocompatibility,
activity,
be
fabricated
within
several
minutes.
These
advantages
enable
efficiently
stop
(blood
loss
amount:
110
mg;
time:
25
s)
promote
process
(wound
closure
rate
2
weeks:
83%),
which
verified
using
rat
models
liver
bleeding
infected
full
thickness
defect.
Overall,
this
facile
design
incorporating
unique
will
greatly
advance
hydrogel's
application
