Thiophene π‐Bridge Manipulation of NIR‐II AIEgens for Multimodal Tumor Phototheranostics

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(14)

Published: Feb. 12, 2024

Abstract The fabrication of a multimodal phototheranostic platform on the basis single‐component theranostic agent to afford both imaging and therapy simultaneously, is attractive yet full challenges. emergence aggregation‐induced emission luminogens (AIEgens), particularly those emit fluorescence in second near‐infrared window (NIR‐II), provides powerful tool for cancer treatment by virtue adjustable pathway radiative/non‐radiative energy consumption, deeper penetration depth aggregation‐enhanced performance. Although bulky thiophene π‐bridges such as ortho ‐alkylated thiophene, 3,4‐ethoxylene dioxythiophene benzo[ c ]thiophene are commonly adopted construct NIR‐II AIEgens, subtle differentiation their behaviours has be comprehensively investigated. In this work, systematical investigations discovered that AIEgen BT‐NS bearing possesses acceptable intensity, efficient reactive oxygen species generation, high photothermal conversion efficiency. Eventually, using nanoparticles, unprecedented performance fluorescence/photoacoustic/photothermal imaging‐guided synergistic photodynamic/photothermal elimination tumors was demonstrated. This study thus offers useful insights into developing versatile systems clinical trials.

Language: Английский

---

Lanthanide-based nanoparticles for cancer phototherapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 508, P. 215773 - 215773

Published: March 14, 2024

Phototherapy, using light as a therapeutic modality, has been widely applied in treating various diseases, especially cancer. This approach is valued for its non-invasive nature and minimal risk of drug resistance. However, phototherapy faces challenges such the undesired delivery phototherapeutic agents, potential phototoxicity, limited penetration into tissues. Lanthanide-doped nanoparticles offer attractive opportunities to improve efficacy photodynamic therapy. These are distinguished by their unique optical properties, excellent photostability against blinking bleaching effects, large Stokes or anti-Stokes shifts, sharp emission peaks, long luminescence lifetimes. In addition, lanthanide-doped can be excited near-infrared (NIR) X-rays, enabling deep-tissue penetration. Beyond use photosensitizers, nanoparticle surfaces easily modified with targeting ligands, chemical drugs, functional molecules enhance effectiveness enable combination this review, we organize lanthanide-based tumor six main domains: therapy, photothermal X-ray-based light-controlled photoimmunotherapy, other innovative treatments that regulated light. We introduce basic principles characteristics lanthanide nanoparticles. Following this, summarize latest advances utilizing phototherapy, focusing on design principles, mechanisms action, cancer treatment. To conclude, address existing explore future within area research.

Language: Английский

---

Biometallic ions and derivatives: a new direction for cancer immunotherapy

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 15, 2025

Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.

Language: Английский

---

Ginger-Derived Exosome-Like Nanoparticles Loaded With Indocyanine Green Enhances Phototherapy Efficacy for Breast Cancer

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1147 - 1169

Published: Jan. 1, 2025

Phototherapy has remarkable advantages in cancer treatment, owing to its high efficiency and minimal invasiveness. Indocyanine green (ICG) plays an important role photo-mediated therapy. However, it several disadvantages such as poor stability aqueous solutions, easy aggregation of molecules, short plasma half-life. This study aimed develop efficient nanoplatform enhance the effects We developed a novel bio-nanoplatform by integrating edible ginger-derived exosome-like nanoparticles (GDNPs) photosensitizer, ICG (GDNPs@ICG). GDNPs were isolated from ginger juice loaded with co-incubation. The size distribution, zeta potential, morphology, total lipid content, drug release behavior GDNPs@ICG characterized. photothermal performance, cellular uptake cytotoxicity, anti-tumor effects, mechanism action investigated both vitro vivo. taken up tumor cells via lipid-dependent pathway. When irradiated 808 nm NIR laser, generated levels ROS, MDA, local hyperthermia within tumor, which caused peroxidation ER stress, thus enhancing breast therapy effect. Furthermore, vivo studies demonstrated that engineered significantly inhibited growth presented limited toxicity. Moreover, detecting expression CD31, N-cadherin, IL-6, IFN-γ, CD8, p16, p21, p53 tissues, we found substantially reduced angiogenesis, metastasis, activated immune response, promoted cell senescence tumor. Our enhanced therapeutic effect could be alternative for precise phototherapy.

Language: Английский

---

Predicting tissue distribution and tumor delivery of nanoparticles in mice using machine learning models

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 374, P. 219 - 229

Published: Aug. 16, 2024

Nanoparticles (NPs) can be designed for targeted delivery in cancer nanomedicine, but the challenge is a low efficiency (DE) to tumor site. Understanding impact of NPs' physicochemical properties on target tissue distribution and DE help improve design nanomedicines. Multiple machine learning artificial intelligence models, including linear regression, support vector machine, random forest, gradient boosting, deep neural networks (DNN), were trained validated predict based therapeutic strategies with dataset from Nano-Tumor Database. Compared other DNN model had superior predictions tumors major tissues. The determination coefficients (R

Language: Английский

---

Harnessing nanotechnology for cancer treatment

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 20, 2025

Nanotechnology has become a groundbreaking innovation force in cancer therapy, offering innovative solutions to the limitations of conventional treatments such as chemotherapy and radiation. By manipulating materials at nanoscale, researchers have developed nanocarriers capable targeted drug delivery, improving therapeutic efficacy while reducing systemic toxicity. Nanoparticles like liposomes, dendrimers, polymeric nanomaterials shown significant promise delivering chemotherapeutic agents directly tumor sites, enhancing bioavailability minimizing damage healthy tissues. In addition with utilization tools quantum dots nanosensors that enables more precise identification biomarkers, nanotechnology is also playing pivotal role early detection diagnosis. Furthermore, nanotechnology-based strategies, including photothermal gene therapy immunotherapy are novel ways combat by selectively targeting cells immune response. Nevertheless, despite these progressions, obstacles still persist, particularly clinical translation technologies. Issues nanoparticle toxicity, biocompatibility, complexity regulatory approval hinder widespread adoption nanomedicine oncology. This review discusses different applications highlighting its potential hurdles implementation. Future research needs concentrate on addressing unlock full providing personalized, effective, minimally invasive treatments.

Language: Английский

---

Phase-separating Pt(IV)-graft-glycopeptides sequentially sensing pH and redox for deep tumor penetration and targeting chemotherapy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 743 - 756

Published: Jan. 25, 2025

Language: Английский

---

pH/glutathione dual-responsive copper sulfide-coated organic mesoporous silica for synergistic chemo-photothermal therapy

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 657, P. 1 - 14

Published: Nov. 26, 2023

Language: Английский

---

Curcumin-encapsulated fish gelatin-based microparticles from microfluidic electrospray for postoperative gastric cancer treatment

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127763 - 127763

Published: Nov. 2, 2023

Language: Английский

---

A nanomedicine composed of polymer-ss-DOX and polymer-Ce6 prodrugs with monoclonal antibody targeting effect for anti-tumor chemo-photodynamic synergetic therapy

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 179, P. 272 - 283

Published: March 7, 2024

Language: Английский

---