Programming assembly of biomimetic exosomes: An emerging theranostic nanomedicine platform

Materials Today Bio, Journal Year: 2023, Volume and Issue: 22, P. 100760 - 100760

Published: Aug. 11, 2023

Exosomes have emerged as a promising cell-free therapeutic approach. However, challenges in large-scale production, quality control, and heterogeneity must be overcome before they can used clinically. Biomimetic exosomes containing key components of natural been assembled through extrusion, artificial synthesis, liposome fusion to address these limitations. These exosome-mimetics (EMs) possess similar morphology function but provide higher yields, faster size compared conventional exosomes. This article provides an overview the chemical biological properties various synthetic exosome systems, including nanovesicles (NVs), EMs, hybrid We highlight recent advances production applications nanobiotechnology discuss advantages, limitations, potential clinical programming assembly mimetics.

Language: Английский

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Exosome for mRNA delivery: strategies and therapeutic applications

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 4, 2024

Abstract Messenger RNA (mRNA) has emerged as a promising therapeutic molecule with numerous clinical applications in treating central nervous system disorders, tumors, COVID-19, and other diseases. mRNA therapies must be encapsulated into safe, stable, effective delivery vehicles to preserve the cargo from degradation prevent immunogenicity. Exosomes have gained growing attention because of their good biocompatibility, low immunogenicity, small size, unique capacity traverse physiological barriers, cell-specific tropism. Moreover, these exosomes can engineered utilize natural carriers target specific cells or tissues. This targeted approach will enhance efficacy reduce side effects mRNAs. However, difficulties such lack consistent reliable methods for exosome purification efficient encapsulation large mRNAs addressed. article outlines current breakthroughs cell-derived vesicle-mediated its biomedical applications. Graphical

Language: Английский

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Synthesis of PVA-Based Hydrogels for Biomedical Applications: Recent Trends and Advances

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 88 - 88

Published: Jan. 23, 2025

There is ongoing research for biomedical applications of polyvinyl alcohol (PVA)-based hydrogels; however, the execution this has not yet been achieved at an appropriate level commercialization. Advanced perception necessary design and synthesis suitable materials, such as PVA-based hydrogel applications. Among polymers, drawn great interest in owing to their attractive potential with characteristics good biocompatibility, mechanical strength, apposite water content. By designing approach investigating structure, hydrogels can attain superb cytocompatibility, flexibility, antimicrobial activities, signifying that it a candidate tissue engineering regenerative medicine, drug delivery, wound dressing, contact lenses, other fields. In review, we highlight current progresses on explaining diverse usage across variety areas. We explain numerous techniques related phenomena based these materials. This review may stipulate wide reference future acumens materials extensive

Language: Английский

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Targeted immunotherapy: harnessing the immune system to battle multiple myeloma

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 27, 2024

Abstract Multiple myeloma (MM) remains an incurable hematological malignancy disease characterized by the progressive dysfunction of patient’s immune system. In this context, immunotherapy for MM has emerged as a prominent area research in recent years. Various targeted strategies, such monoclonal antibodies, antibody-drug conjugates, bispecific chimeric antigen receptor T cells/natural killer (NK) cells, and checkpoint inhibitors have been developed MM. This review aims to discuss promising experimental clinical evidence well mechanisms action underlying these immunotherapies. Specifically, we will explore design exosome-based antibodies that offer cell-free options. The treatment landscape continues evolve with development numerous emerging Given their significant advantages modulating environment through immune-targeted therapy, approaches provide novel perspectives selecting cutting-edge treatments

Language: Английский

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Extracellular Vesicles: A New Star for Gene Drug Delivery

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2241 - 2264

Published: March 1, 2024

Abstract: Recently, gene therapy has become a subject of considerable research and been widely evaluated in various disease models. Though it is considered as stand-alone agent for COVID-19 vaccination, still suffering from the following drawbacks during its translation bench to bedside: high sensitivity exogenous nucleic acids enzymatic degradation; severe side effects induced either by or components formulation; difficulty cross barriers before reaching therapeutic target. Therefore, successful application therapy, safe reliable transport vector urgently needed. Extracellular vesicles (EVs) are ideal candidate delivery drugs owing their low immunogenicity, good biocompatibility toxicity. To better understand properties EVs advantages drug vehicles, this review covers origin methods generation, well common isolation purification research, with pros cons discussed. Meanwhile, engineering also highlighted. In addition, paper presents progress EVs-mediated microRNAs, small interfering RNAs, messenger plasmids, antisense oligonucleotides. We believe will provide theoretical basis development drugs. Keywords: extracellular vesicles, system,

Language: Английский

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Bone Targeting Nanoparticles for the Treatment of Osteoporosis

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1363 - 1383

Published: Feb. 1, 2024

Osteoporosis (OP) affects millions of people worldwide, especially postmenopausal women and the elderly. Although current available anti-OP agents can show promise in slowing down bone resorption, most are not specifically delivered to hard tissue, causing significant toxicity. A bone-targeted nanodrug delivery system reduce side effects precisely deliver drug candidates bone. This review focuses on progress nanoparticles OP therapy. We enumerate existing medications, types categorize pairs common bone-targeting functional groups. Finally, we summarize potential use treatment. Ongoing research into development targeted ligands nanocarriers will continue expand possibilities OP-targeted therapies clinical application.

Language: Английский

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Optimization of exosome-based cell-free strategies to enhance endogenous cell functions in tissue regeneration

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 171, P. 68 - 84

Published: Sept. 19, 2023

Language: Английский

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Efficiently directing differentiation and homing of mesenchymal stem cells to boost cartilage repair in osteoarthritis via a nanoparticle and peptide dual-engineering strategy

Biomaterials, Journal Year: 2024, Volume and Issue: 312, P. 122720 - 122720

Published: July 27, 2024

Language: Английский

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Exosomes as new generation vehicles for drug delivery systems

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105562 - 105562

Published: March 11, 2024

Language: Английский

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Injectable microspheres adhering to the cartilage matrix promote rapid reconstruction of partial-thickness cartilage defects

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 179, P. 220 - 233

Published: March 28, 2024

Language: Английский

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