Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)
Published: April 20, 2024
Language: Английский
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: April 24, 2025
Cartilage is crucial for joints, and its damage can lead to pain functional impairment, causing financial burden patients. Due weak self-repair, cartilage injury control a research focus. naturally with age, but mechanical trauma, lifestyle factors certain genetic abnormalities increase the likelihood of symptomatic disease progression. Current treatments include pharmacological surgical interventions, these lack ability stop progression restore regeneration cartilage. Biological therapies have been evaluated show varying degrees efficacy in long-term. The mesenchymal stem cell (MSC) therapy attracts attention as it easily harvested expanded. Once thought repair via differentiation, MSCs are now known secrete extracellular vesicles (EVs) paracrinely. These EVs, rich bioactive molecules, enable communication, boost growth factor secretion, regulate synthesis degradation matrix (ECM), modulate inflammation, vital repair. However, further clinical validation still required application MSC MSC-EVs. This review highlights current state on use MSC-EVs treatment injury. It hoped that this paper will provide valuable references inspiration future researchers therapeutic studies
Language: Английский
Citations
0
Bioengineering, Journal Year: 2024, Volume and Issue: 11(3), P. 246 - 246
Published: March 1, 2024
The unique physical demands of tactical athletes put immense stress on the knee joint, making these individuals susceptible to injury. In order ensure operational readiness, management options must restore and preserve native architecture minimize downtime, while optimizing functionality. Osteochondral lesions (OCL) have long been acknowledged as significant sources pain functional deficits. OCL is predicated certain injury characteristics, including lesion location extent subchondral disease. Techniques such marrow stimulation, allograft autologous chondrocyte implantation are examined in detail, with a focus their application suitability athlete populations. Moreover, restoration osteochondral unit (OCU) highlighted central aspect joint preservation. discussion encompasses biomechanical considerations outcomes associated various cartilage techniques. Factors influencing procedure selection, size, location, patient-specific variables, thoroughly examined. Additionally, review underscores critical role post-operative rehabilitation conditioning programs outcomes. Strengthening surrounding musculature, enhancing stability, refining movement patterns paramount facilitating successful integration preservation procedures. This narrative aims provide comprehensive resource for surgeons, engineers, sports medicine practitioners engaged care field restoration. advanced techniques tailored protocols offers promising avenue sustaining health function this demanding population.
Language: Английский
Citations
3
ACS Materials Letters, Journal Year: 2024, Volume and Issue: unknown, P. 3862 - 3882
Published: July 24, 2024
Osteoarthritis (OA) is a chronic condition characterized by degeneration of the articular cartilage and subsequent bone hyperplasia. With increasing prevalence driven factors such as aging obesity, OA poses growing health economic burden. Current treatments, including NSAIDs corticosteroid injections, offer limited efficacy often result in adverse effects, highlighting urgent need for novel therapeutic approaches. Emerging research has identified hydrogel microspheres promising solution management. These microspheres, with their tunable physicochemical properties biocompatibility, provide conducive environment regeneration sustained drug delivery. Unlike bulk hydrogels, enhanced injectability, uniform distribution, reduced tissue damage. This review discusses recent advancements microsphere technology, focusing on fabrication, unique mechanisms, applications OA. Additionally, we address challenges future directions clinical translation, aim to optimize treatment.
Language: Английский
Citations
3
Experimental Cell Research, Journal Year: 2024, Volume and Issue: 436(2), P. 113981 - 113981
Published: Feb. 20, 2024
Language: Английский
Citations
2
Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)
Published: April 20, 2024
Language: Английский
Citations
2