Spatiotemporally Controlled Photothermal-Enhanced Cascade Nanoreactor for Efficient Antitumor Therapy through Tumor Microenvironment Modulation DOI
Li Zhao, Jing Gao, Z T Sun

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(24), P. 28788 - 28797

Published: Dec. 11, 2024

The primary challenges for nanozyme-mediated tumor catalytic therapy are the insufficient activity of nanozymes and inadequate endogenous hydrogen peroxide (H2O2) levels in microenvironment (TME). To address these challenges, FeMOF/Pt/GOx (FMPG), a TME-responsive cascade nanoreactor, was designed photothermal-cascade antitumor therapy. FMPG comprises MIL-100(Fe), an iron-based metal–organic framework material, loaded with ultrasmall platinum nanoparticles (Pt NPs) glucose oxidase (GOx). Within TME, degrades presence high phosphate concentrations, releasing GOx, Fe2+, Pt NPs. GOx consumes glucose, reducing ATP cells inducing starvation state cells. Subsequently, H2O2 produced by overexpressed reacts Fe2+ to generate hydroxyl radicals, facilitating NPs exhibit catalase-like catalyze production oxygen from H2O2, further enhancing starvation. Under 808 nm laser irradiation, as-prepared composites localized heat, enabling effective photothermal This nanoreactor demonstrates efficient inhibition situ consumption compounds, promoting development precise synergetic cancer therapies spatiotemporal controllability.

Language: Английский

Photodynamic therapy with NIR-II probes: review on state-of-the-art tools and strategies DOI
Yiqian Yang, Shaohua Jiang, Stefan G. Stanciu

et al.

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(23), P. 5815 - 5842

Published: Jan. 1, 2024

The current state-of-the art on NIR-II-activated photosensitizers and their applications for the deep tumor treatment, as well recent efforts that combine NIR-II activated PDT with other complementary therapeutic routes.

Language: Английский

Citations

8
Recent advances and mechanism of plasmonic metal–semiconductor photocatalysis DOI Creative Commons
Ting Kong, Aizhen Liao, Yonggang Xu

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(24), P. 17041 - 17050

Published: Jan. 1, 2024

Recent advances and mechanism of plasmonic metal–semiconductor photocatalysis.

Language: Английский

Citations

7
Photoresponsive Multirole Nanoweapon Camouflaged by Hybrid Cell Membrane Vesicles for Efficient Antibacterial Therapy of Pseudomonas aeruginosa‐Infected Pneumonia and Wound DOI Creative Commons
Hening Liu,

Lu Tang,

Yue Yin

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 15, 2024

Exploring effective antibacterial approaches for targeted treatment of pathogenic bacterial infections with reduced drug resistance is great significance. Combinational modality that leverages different therapeutic components can improve the overall effectiveness and minimize adverse effects, thus displaying considerable potential against infections. Herein, red blood cell membrane fuses macrophage to develop hybrid shell, which further camouflages around drug-loaded liposome fabricate biomimetic (AB@LRM) precise therapy. Specifically, photoactive agent black phosphorus quantum dots (BPQDs) classical antibiotics amikacin (AM) are loaded in AB@LRM accurately target inflammatory sites through guidance long residence capability membrane, eventually exerting efficacious activities. Besides, due excellent photothermal photodynamic properties, BPQDs act as an efficient when exposed near-infrared laser irradiation, dramatically increasing sensitivity bacteria antibiotics. Consequently, synergistic sterilizing effect produced by restricts resistance. Upon shows superior anti-inflammatory properties models P. aeruginosa-infected pneumonia wounds. Hence, this light-activatable nanoplatform good biocompatibility presents advance clinical development

Language: Английский

Citations

7
Organic–Inorganic Heterointerface-Expediting Electron Transfer Realizes Efficient Plasmonic Catalytic Sterilization via a Carbon-Dot Nanozyme DOI
Guopeng Xu, Zhiyuan Ren, Jiachen Xu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(17), P. 21689 - 21698

Published: April 17, 2024

Plasmonic nanozymes bring enticing prospects for catalytic sterilization by leveraging plasmon-engendered hot electrons. However, the interface between plasmons and as mandatory path of electrons receives little attention, mechanisms plasmonic still remain to be elucidated. Herein, a carbon-dot nanozyme (FeCG) is developed electrostatically assembling iron-doped carbon dots (Fe-CDs) with gold nanorods. The energy harvesting hot-electron migration are remarkably expedited spontaneous organic-inorganic heterointerface holding Fermi level-induced interfacial electric field. accumulated then fully utilized conductive Fe-CDs boost enzymatic catalysis toward overproduced reactive oxygen species. By synergizing localized heating from decay, FeCG achieves rapid potent disinfection an antibacterial efficiency 99.6% on Escherichia coli within 5 min also effective (94.2%) against Staphylococcus aureus. Our work presents crucial insights into in advanced biocidal nanozymes.

Language: Английский

Citations

5
Catalytic Dual‐Mode Immunotherapy: Anisotropic AuPt Heterostructure Decorated with Starry Pt Nanoclusters for Robust Cancer Photometalloimmunotherapy DOI Creative Commons
Wei Bian, Xi Hu,

Ruixue Xiao

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(28)

Published: May 30, 2024

Abstract To overcome current limitations in photoimmunotherapy, such as insufficient tumor antigen generation and a subdued immune response, novel photo‐/metallo dual‐mode immunotherapeutic agent (PMIA) is introduced for potent near‐infrared (NIR) light‐triggered cancer therapy. PMIA features dumbbell‐like AuPt heterostructure decorated with starry Pt nanoclusters, meticulously engineered enhancing plasmonic catalysis through multi‐dimensional regulation of growth on Au nanorods. Under NIR laser exposure, end‐tipped nanoclusters induce efficient electron‐hole spatial separation along the longitudinal axis, resulting radial axial electron distribution polarization, conferring unique anisotropic properties to PMIA. Additionally, sides nanorods augment local enrichment field. Validated finite‐difference time‐domain analysis Raman scattering, this configuration fosters enrichment, facilitating robust reactive oxygen species photoimmunotherapy. Moreover, facilitate 2+ ion release, instigating intranuclear DNA damage inducing synergistic immunogenic cell death (ICD) metalloimmunotherapy. Consequently, elicits abundant danger‐associated molecular patterns, promotes T infiltration, triggers systemic responses, effectively treating primary distant tumors, inhibiting metastasis vivo. This study unveils pioneering ICD amplification strategy driven by light, synergistically integrating photoimmunotherapy metalloimmunotherapy, culminating photometalloimmunotherapy.

Language: Английский

Citations

5
A comprehensive review on the recent applications of nanozymes in breast cancer therapy and diagnosis DOI Creative Commons

Amir Kashtiaray,

Mahdi Karimi, Mostafa Ghafori-Gorab

et al.

Materials Advances, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Nanozymes have been developed as engineered nanomaterials that mimic the catalytic functions of natural enzymes.

Language: Английский

Citations

0
Configuration-mediated excited-state energy dissipation in metal-bridged dimeric D-A fluorophores for enhanced photothermal therapy DOI Open Access

Shibo Lv,

Bo Wang, Yingnan Wu

et al.

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 174, P. 400 - 411

Published: Nov. 28, 2023

Language: Английский

Citations

8
A Triple-Functional Antibacterial Platform Based on Quaternized Ru(II) Complex-Loaded MXene Composites DOI

Yuanhong Zhou,

Ziyuan Zong,

Mohamed S. Selim

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(14), P. 16450 - 16465

Published: July 18, 2024

Language: Английский

Citations

3
Metal nanozymes modulation of reactive oxygen species as promising strategies for cancer therapy DOI

Jin-Wei Bu,

Zhigang Wang,

Haoyang Liu

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124453 - 124453

Published: July 14, 2024

Language: Английский

Citations

2
Biophysical and computational analysis of interaction of 2D MoS2 nanosheets with human haemoglobin coupled with NIR activated photothermal therapy DOI

Kritika,

Deepika,

Loveneesh Kumar

et al.

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(24), P. 10990 - 11002

Published: Jan. 1, 2024

Molybdenum disulfide (MoS 2 ) nanosheets can interact favourably with human haemoglobin and induce apoptosis in cancer cells via NIR-excited photothermal therapy.

Language: Английский

Citations

1