International Journal of Polymeric Materials,
Journal Year:
2023,
Volume and Issue:
73(10), P. 851 - 865
Published: May 25, 2023
Cartilage
joint
lesions
have
created
a
significant
challenge
in
the
field
of
durable
reconstruction
and
recovery
due
to
their
limited
long-term
repair
reconstruction.
In
this
study,
biphasic
scaffold
was
obtained
using
chitosan
(CS)-hyaluronic
acid
(HA)
alginate-nanohydroxyapatite
(nHAP)
for
osteoarthritis
diseases.
The
scaffolds
revealed
porous
structures
hydrophilic
chemical
groups
by
scanning
electron
microscopy
(SEM)
Fourier-transform
infrared
spectroscopy
(FTIR)
methods,
respectively.
resulting
three-dimensional
hydrogels
were
assembled
fibrin
glue
seeded
with
human
chondrocytes
cells
(hCHCs)
chondral
layer
adipose-derived
mesenchymal
stem
(hAdMSCs)
subchondral
one.
Then,
assessments
including
3-(4,
5-dimethylthiazol-2-yl)-2,
5-diphenyltetrazolium
bromide
(MTT),
SEM,
compressive
assay,
weight
loss,
alizarin
red
staining,
alkaline
phosphatase
(ALP)
activity,
alcian
blue
staining
Real-Time
PCR
performed.
associated
cell
viability
confirmed
that
there
no
interventions
between
types
SEM
illustrated
attachment
spreading.
layers
investigated
separately
detect
ability
cellular
commitment.
Finally,
Real-time
carried
out
on
bilayer
related
observations
approved
osteogenic/chondrogenic
differentiation
both
types.
Taken
together,
Alg-nHAP/CS-HA
provided
an
appropriate
environment
cartilage
bone
regenerations
could
be
recommended
all
aspects
osteochondral
tissue
engineering.
Nano Materials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 1, 2024
The
field
of
photocatalysis
has
witnessed
a
significant
advancement
in
the
development
bioinspired
and
biomimetic
photocatalysts
for
various
biomedical
applications,
including
drug
delivery,
tissue
engineering,
cancer
therapy,
bioimaging.
Nature
evolved
efficient
light-harvesting
systems
energy
conversion
mechanisms,
which
serve
as
benchmark
researchers.
However,
reproducing
such
complexity
harnessing
it
applications
is
daunting
task.
It
requires
comprehensive
understanding
underlying
biological
processes
ability
to
replicate
them
synthetically.
By
utilizing
light
energy,
these
can
trigger
specific
chemical
reactions,
leading
targeted
release,
enhanced
regeneration,
precise
imaging
structures.
In
this
context,
addressing
stability,
long-term
performance,
scalability,
cost-effectiveness
materials
crucial
their
widespread
implementation
applications.
While
challenges
stability
persist,
advantages
delivery
personalized
medicine
make
fascinating
area
research.
purpose
review
provide
analysis
evaluation
existing
research,
highlighting
advancements,
current
challenges,
advantages,
limitations,
future
prospects
biomedicine.
Biomimetics,
Journal Year:
2024,
Volume and Issue:
9(7), P. 390 - 390
Published: June 26, 2024
This
review
explores
the
extensive
applications
of
plants
in
areas
biomimetics
and
bioinspiration,
highlighting
their
role
developing
sustainable
solutions
across
various
fields
such
as
medicine,
materials
science,
environmental
technology.
Plants
not
only
serve
essential
ecological
functions
but
also
provide
a
rich
source
inspiration
for
innovations
green
nanotechnology,
biomedicine,
architecture.
In
past
decade,
focus
has
shifted
towards
utilizing
plant-based
vegetal
waste
creating
eco-friendly
cost-effective
with
remarkable
properties.
These
are
employed
making
advancements
drug
delivery,
remediation,
production
renewable
energy.
Specifically,
discusses
use
(nano)bionic
capable
detecting
explosives
contaminants,
underscoring
potential
improving
quality
life
even
lifesaving
applications.
The
work
refers
to
architectural
inspirations
drawn
from
plant
world
develop
novel
design
concepts
that
both
functional
aesthetic.
It
elaborates
on
how
engineered
have
been
transformed
into
value-added
through
innovative
applications,
especially
roles
wastewater
treatment
electronic
components.
Moreover,
integration
synthesis
biocompatible
medical
tissue
engineering
scaffolds
artificial
muscles
demonstrates
versatility
capacity
replace
more
traditional
synthetic
materials,
aligning
global
sustainability
goals.
paper
provides
comprehensive
overview
current
uses
living
technological
advancements,
advocating
deeper
exploration
address
pressing
challenges.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(28), P. 30097 - 30108
Published: July 2, 2024
Osteochondral
defects
affect
articular
cartilage,
calcified
and
subchondral
bone.
The
main
problem
that
they
cause
is
a
different
behavior
of
cell
tissue
in
the
osteochondral
bone
part.
Articular
cartilage
composed
mainly
collagen
II,
glycosaminoglycan
(GAG),
water,
has
low
healing
ability
due
to
lack
vascularization.
However,
I,
proteoglycans,
inorganic
composites
such
as
hydroxyapatite.
Due
discrepancy
between
characters
these
two
parts,
it
difficult
find
materials
will
meet
all
structural
other
requirements
for
effective
regeneration.
When
designing
scaffold
an
defect,
variety
are
available,
e.g.,
polymers
(synthetic
natural),
particles,
extracellular
matrix
(ECM)
components.
All
them
require
accurate
characterization
prepared
number
vitro
vivo
tests
before
applied
patients.
Taken
concert,
final
material
needs
mimic
structural,
morphological,
chemical,
cellular
demands
native
tissue.
In
this
review,
we
present
overview
structure
composition
part,
especially
synthetic
with
additives
appropriate
defects.
Finally,
summarize
methods
suitable
evaluating
restoring
Tissue Engineering Part B Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 14, 2024
The
dura
mater,
the
furthest
and
strongest
layer
of
meninges,
is
crucial
for
protecting
brain
spinal
cord.
Its
biomechanical
behavior
vital,
as
any
alterations
can
compromise
biological
functions.
In
recent
decades,
interest
in
mater
has
increased
due
to
need
hermetic
closure
dural
defects
prompting
development
several
substitutes.
Collagen-based
substitutes
are
common
commercial
options,
but
they
lack
complex
structural
elements
native
impacting
regeneration
potentially
causing
complications
like
wound/postoperative
infection
cerebrospinal
fluid
(CSF)
leakage.
To
face
this
issue,
tissue
engineering
approaches
focus
on
creating
biomimetic
objective
review
discuss
whether
mimicking
mechanical
properties
or
ensuring
high
biocompatibility
bioactivity
more
critical
developing
effective
substitutes,
if
both
aspects
should
be
systematically
linked.
After
a
brief
description
architecture
cranial
dura,
we
describe
advantages
limitations
better
understand
their
relevance.
particular,
consider
properties'
impact
repair's
effectiveness.
Finally,
obstacles
perspectives
ideal
substitute
explored.
Journal of Polymer Science,
Journal Year:
2024,
Volume and Issue:
62(20), P. 4730 - 4741
Published: July 31, 2024
Abstract
An
approach
that
combines
a
modified
electrospinning
method
with
thermal
stretching
post‐treatment
is
designed
to
fabricate
poly(l‐lactide‐co‐ε‐caprolactone)
(PLCL)
electrospun
nanofiber
yarns
(ENYs).
The
diameter
in
the
PLCL
ENYs
found
present
an
increasing
trend
of
polymeric
concentration.
When
concentration
reaches
13%
(w/v),
as‐generated
show
bead‐free
and
uniform
nanofibrous
structure.
Then,
thermally
technique
applied
process
primarily‐obtained
ENYs.
temperature
set
as
60
°C,
thermally‐stretched
superior
fiber
orientation
notably
enhanced
crystallinity,
thus
resulting
dramatically
increased
mechanical
properties.
Finally,
stretched
are
further
processed
into
braided
fabrics,
their
properties
possess
obviously
ENY
numbers,
demonstrating
adjustment
feasibility
ENY‐based
textiles
by
controlling
numbers.
Importantly,
vitro
cell
studies
demonstrate
significantly
support
adhesion
proliferation
human
dermal
fibroblasts
(HDFs).
In
all,
study
provides
easily‐handling
strategy
high
performance
ENYs,
which
shows
promising
future
for
generation
advanced
biomedical
textiles.
Revista Mexicana de Ingeniería Biomédica,
Journal Year:
2023,
Volume and Issue:
44(3), P. 24 - 36
Published: Sept. 1, 2023
About
two
decades
ago,
medicine
experienced
a
revolutionary
approach,
driven
by
technological
development
in
manufacturing
techniques
and
scientific
advances
the
medical
life
sciences,
field
took
on
challenge
of
regenerating
tissue
organs
damaged
disease,
trauma,
or
hereditary
issues,
incorporating
additive
as
one
its
strategies.
Since
inception,
regenerative
has
developed
like
engineering,
cellular
therapy,
devices,
artificial
to
provide
wound
healing
orthopedic
applications.
The
incorporation
allowed
recreate
biologically
appropriate
environments
for
cell
reproduction
growth
that,
eventually,
lead
useful,
regenerated
organs.
objective
present
work
is
review
recent
application
ad
hoc
biomaterials
medicine,
determine
their
impact
new
therapies
engineering.
