Multimaterial 3D and 4D Bioprinting of Heterogenous Constructs for Tissue Engineering

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(34)

Published: Sept. 22, 2023

Additive manufacturing (AM), which is based on the principle of layer-by-layer shaping and stacking discrete materials, has shown significant benefits in fabrication complicated implants for tissue engineering (TE). However, many native tissues exhibit anisotropic heterogenous constructs with diverse components functions. Consequently, replication biomimetic using conventional AM processes a single material challenging. Multimaterial 3D 4D bioprinting (with time as fourth dimension) emerged promising solution constructing multifunctional that can mimic host microenvironment better than single-material alternatives. Notably, 4D-printed multimaterial architectures provide time-dependent programmable dynamic promote cell activity regeneration response to external stimuli. This paper first presents typical design strategies TE applications. Subsequently, latest are discussed, along their advantages challenges. In particular, potential smart highlighted. Furthermore, this review provides insights into how facilitate realization next-generation

Language: Английский

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Biomaterials for Drug Delivery and Human Applications

Materials, Journal Year: 2024, Volume and Issue: 17(2), P. 456 - 456

Published: Jan. 18, 2024

Biomaterials embody a groundbreaking paradigm shift in the field of drug delivery and human applications. Their versatility adaptability have not only enriched therapeutic outcomes but also significantly reduced burden adverse effects. This work serves as comprehensive overview biomaterials, with particular emphasis on their pivotal role delivery, classifying them terms biobased, biodegradable, biocompatible nature, highlighting characteristics advantages. The examination delves into extensive array applications for biomaterials encompassing diverse medical fields such cancer therapy, cardiovascular diseases, neurological disorders, vaccination. explores actual challenges within this domain, including potential toxicity complexity manufacturing processes. These emphasize necessity thorough research continuous development regulatory frameworks. second aim review is to navigate through compelling terrain recent advances prospects envisioning healthcare landscape where they empower precise, targeted, personalized delivery. transform staggering, promise treatments tailored individual patient needs, offering hope improved efficacy, fewer side effects, brighter future practice.

Language: Английский

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Tough polyvinyl alcohol-gelatin biological macromolecules ionic hydrogel temperature, humidity, stress and strain, sensors

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 249, P. 125978 - 125978

Published: July 27, 2023

Language: Английский

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Advancements in tissue engineering for cardiovascular health: a biomedical engineering perspective

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: May 31, 2024

Myocardial infarction (MI) stands as a prominent contributor to global cardiovascular disease (CVD) mortality rates. Acute MI (AMI) can result in the loss of large number cardiomyocytes (CMs), which adult heart struggles replenish due its limited regenerative capacity. Consequently, this deficit CMs often precipitates severe complications such failure (HF), with whole transplantation remaining sole definitive treatment option, albeit constrained by inherent limitations. In response these challenges, integration bio-functional materials within cardiac tissue engineering has emerged groundbreaking approach significant potential for replacement. Bioengineering strategies entail fortifying or substituting biological tissues through orchestrated interplay cells, methodologies, and innovative materials. Biomaterial scaffolds, crucial paradigm, provide essential microenvironment conducive assembly functional encapsulating contracting cells. Indeed, field witnessed remarkable strides, largely owing application biomaterial scaffolds. However, complexities persist, necessitating further exploration innovation. This review delves into pivotal role scaffolds engineering, shedding light on their utilization, challenges encountered, promising avenues future advancement. By critically examining current landscape, we aim catalyze progress toward more effective solutions regeneration ultimately, improved outcomes patients grappling ailments.

Language: Английский

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Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(6), P. 531 - 531

Published: March 16, 2024

Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic adds complexity to traditional cell cultivation methods. most commonly used technique involves cultivating cells on flat surface in two-dimensional format due its simplicity. A three-dimensional (3D) provide microenvironment for surrounding cells. There two main techniques obtaining 3D structures based the presence scaffolding. Scaffold-free consist spheroid technologies. Meanwhile, scaffold contain organoids all constructs that various types scaffolds, ranging from decellularized extracellular matrix (dECM) through hydrogels one extensively studied forms potential culture up 4D bioprinted biomaterials. bioprinting is important create scaffolds. versatility this allows many different inks, mainly hydrogels, as well inorganic substances. Increasing amounts data evidence vast usage engineering personalized medicine, with area application being regeneration skin musculoskeletal systems. Recent papers also indicate increasing vivo tests products which further strengthen importance branch emphasize need extensive research safe humansbiomimetic tissues organs. In review article, we recent advancements field preceded by an overview technologies led development complex type culture.

Language: Английский

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The application of small intestinal submucosa in tissue regeneration

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101032 - 101032

Published: March 18, 2024

The distinctive three-dimensional architecture, biological functionality, minimal immunogenicity, and inherent biodegradability of small intestinal submucosa extracellular matrix materials have attracted considerable interest found wide-ranging applications in the domain tissue regeneration engineering. This article presents a comprehensive examination structure role submucosa, delving into diverse preparation techniques classifications. Additionally, it proposes approaches for evaluating modifying SIS scaffolds. Moreover, advancements skin, bone, heart valves, blood vessels, bladder, uterus, urethra are thoroughly explored, accompanied by their respective future prospects. Consequently, this review enhances our understanding organ repair keeps researchers up-to-date with latest research area.

Language: Английский

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Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Gels, Journal Year: 2024, Volume and Issue: 10(3), P. 190 - 190

Published: March 9, 2024

The repair of nervous tissue is a critical research field in engineering because the degenerative process injured system. In this review, we summarize progress injectable hydrogels using vitro and vivo studies for regeneration tissue. Traditional treatments have not been favorable patients, as they are invasive inefficient; therefore, promising treatment damaged This review will contribute to better understanding potential scaffolds drug delivery system neural applications.

Language: Английский

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Swim bladder-derived biomaterials: structures, compositions, properties, modifications, and biomedical applications

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 17, 2024

Abstract Animal-derived biomaterials have been extensively employed in clinical practice owing to their compositional and structural similarities with those of human tissues organs, exhibiting good mechanical properties biocompatibility, extensive sources. However, there is an associated risk infection pathogenic microorganisms after the implantation from pigs, cattle, other mammals humans. Therefore, researchers begun explore development non-mammalian regenerative biomaterials. Among these swim bladder, a fish-derived biomaterial that rapidly used various fields biomedicine because its high collagen, elastin, polysaccharide content. relevant reviews on biomedical applications bladders as effective are lacking. based our previous research in-depth understanding this field, review describes structures compositions, properties, modifications direct (including soft tissue repair, dural cardiovascular edible pharmaceutical fish maw) indirect extracted collagen peptides smaller molecular weights, or gelatin higher weights for hydrogels, biological adhesives glues) field recent years. This provides insights into use source biomaterial; hence, it can aid scholars by providing directions advancements field.

Language: Английский

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Biofabrication paradigms in corneal regeneration: bridging bioprinting techniques, natural bioinks, and stem cell therapeutics

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: 35(5), P. 717 - 755

Published: Jan. 12, 2024

Corneal diseases are a major cause of vision loss worldwide. Traditional methods like corneal transplants from donors effective but face challenges limited donor availability and the risk graft rejection. Therefore, new treatment essential. This review examines growing field bioprinting biofabrication in tissue engineering. We begin by discussing various such as stereolithography, inkjet, extrusion printing, highlighting their strengths weaknesses for eye-related uses. also explore how biological tissues made suitable through process called decellularization, which can be achieved using chemical, physical, or methods. The then looks at natural materials, known bioinks, used bioprinting. focus on materials gelatin, collagen, fibrin, chitin, chitosan, silk fibroin, alginate, examining mechanical properties. importance hydrogel scaffolds, particularly those based collagen other is discussed context repairing tissue. Another key area we cover use stem cells regeneration. pay special attention to limbal epithelial mesenchymal stromal cells, roles this process. concludes with an overview latest advancements bioprinting, early techniques advanced delivering bioengineered materials. In summary, presents current state future potential creating functional tissues, developments ongoing view towards restoring vision.

Language: Английский

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Extracellular matrix-induced signaling pathways in mesenchymal stem/stromal cells

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 19, 2023

Abstract The extracellular matrix (ECM) is a crucial component of the stem cell microenvironment, or stem-cell niches, and contributes to regulation behavior fate. Accumulating evidence indicates that different types cells possess large variety molecules responsible for interactions with ECM, mediating specific epigenetic rearrangements corresponding changes in transcriptome profile. Signals from ECM are at all stages ontogenesis, including embryonic postnatal development, as well tissue renewal repair. could regulate transition quiescent state readiness perceive signals differentiation induction (competence) between (commitment). Currently, unveil complex networks cellular signaling multiple approaches screening methods, analysis matrixome, creation predictive protein–protein based on experimental data used. In this review, we consider existing regarded contribution ECM-induced intracellular pathways into focusing mesenchymal stem/stromal (MSCs) well-studied type totally depended ECM. Furthermore, propose system biology-based approach prediction ECM-mediated signal transduction target cells.

Language: Английский

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