Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications DOI Open Access
Domenico Lombardo, Pietro Calandra, Luigi Pasqua

et al.

Materials, Journal Year: 2020, Volume and Issue: 13(5), P. 1048 - 1048

Published: Feb. 26, 2020

In this paper, we survey recent advances in the self-assembly processes of novel functional platforms for nanomaterials and biomaterials applications. We provide an organized overview, by analyzing main factors that influence formation organic nanostructured systems, while putting into evidence challenges, limitations emerging approaches various fields nanotechology biotechnology. outline how building blocks properties, mutual cooperative interactions, as well initial spatial configuration (and environment conditions) play a fundamental role construction efficient materials with desired properties. The insertion endgroups (such polymers, peptides or DNA) within units has enormously increased complexity morphologies functions can be designed fabrication bio-inspired capable mimicking biological activity. However, unwanted uncontrollable effects originating from unexpected thermodynamic perturbations complex interactions interfere at molecular level assembly process. Correction harmonization is one major challenges next decades requires deeper knowledge understanding key drive nanomaterials. Self-assembly still remains central topic current research located interface between material science engineering, biotechnology nanomedicine, it will continue to stimulate renewed interest biologist, physicists engineers combining principles concept supramolecular chemistry.

Language: Английский

Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine DOI Open Access
Domenico Lombardo, Mikhail A. Kiselev, Maria Teresa Caccamo

et al.

Journal of Nanomaterials, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 26

Published: Feb. 27, 2019

The study of nanostructured drug delivery systems allows the development novel platforms for efficient transport and controlled release molecules in harsh microenvironment diseased tissues living systems, thus offering a wide range functional nanoplatforms smart application biotechnology nanomedicine. This article highlights recent advances nanocarriers composed organic (including polymeric micelles vesicles, liposomes, dendrimers, hydrogels) inorganic quantum dots, gold mesoporous silica nanoparticles) materials. Despite remarkable developments synthetic methodologies, most all nanocarriers’ action is associated with number unwanted side effects that diminish their use nanomedicine applications. some critical issues design engineering nanocarrier applications, arising from complex environment multiform interactions established within specific biological media.

Language: Английский

Citations

752
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles DOI Creative Commons
Akhand Pratap Singh, Arpan Biswas, Aparna Wagle Shukla

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2019, Volume and Issue: 4(1)

Published: Aug. 30, 2019

The application of nanomedicines is increasing rapidly with the promise targeted and efficient drug delivery. Nanomedicines address shortcomings conventional therapy, as evidenced by several preclinical clinical investigations indicating site-specific delivery, reduced side effects, better treatment outcome. development suitable biocompatible delivery vehicles a prerequisite that has been successfully achieved using simple functionalized liposomes, nanoparticles, hydrogels, micelles, dendrimers, mesoporous particles. A variety have established for controlled therapeutic agents in wide range chronic diseases, such diabetes, cancer, atherosclerosis, myocardial ischemia, asthma, pulmonary tuberculosis, Parkinson's disease, Alzheimer's disease. After successful outcomes trials, many these drugs marketed human use, Abraxane®, Caelyx®, Mepact®, Myocet®, Emend®, Rapamune®. Apart from drugs/compounds, novel agents, peptides, nucleic acids (DNA RNA), genes also shown potential to be used ailments. However, large number extensive trials are still needed ensure short-term long-term effects humans. This review discusses advantages various understanding their utility terms current medical needs. Furthermore, described context major diseases.

Language: Английский

Citations

511
Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic-co-glycolic acid) micro and nanoparticles DOI Open Access
Enas Elmowafy, Mattia Tiboni, Mahmoud E. Soliman

et al.

Journal of Pharmaceutical Investigation, Journal Year: 2019, Volume and Issue: 49(4), P. 347 - 380

Published: April 16, 2019

Language: Английский

Citations

465
Rapidly separable microneedle patch for the sustained release of a contraceptive DOI Open Access
Wei Li,

Richard N. Terry,

Jie Tang

et al.

Nature Biomedical Engineering, Journal Year: 2019, Volume and Issue: 3(3), P. 220 - 229

Published: Jan. 2, 2019

Language: Английский

Citations

410
A Perspective on Polylactic Acid-Based Polymers Use for Nanoparticles Synthesis and Applications DOI Creative Commons
Tommaso Casalini, Filippo Rossi, A. Castrovinci

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2019, Volume and Issue: 7

Published: Oct. 11, 2019

Polylactic acid (PLA) – based polymers are ubiquitous in the biomedical field thanks to their combination of attractive peculiarities: biocompatibility (degradation products do not elicit critical responses and easily metabolized by body), hydrolytic degradation situ, tailorable properties well–established processing technologies. This led development several applications, such as bone fixation screws, bioresorbable suture threads stent coating, just name a few. Nanomedicine could be unconcerned PLA–based materials well, where use for synthesis nanocarriers targeted delivery hydrophobic drugs emerged new promising application. The purpose here presented review is twofold: on one side, it aims at providing broad overview properties, which allow them gaining leading role field; other offers specific focus recent nanomedicine, highlighting opportunities perspectives.

Language: Английский

Citations

401
Applications of PLA in modern medicine DOI Creative Commons
Vincent DeStefano,

Salaar Khan,

Alonzo Tabada

et al.

Engineered Regeneration, Journal Year: 2020, Volume and Issue: 1, P. 76 - 87

Published: Jan. 1, 2020

Polylactic acid (PLA) is a versatile biopolymer. PLA synthesized with ease from abundant renewable resources and biodegradable. has shown promise as biomaterial in plethora of healthcare applications such tissue engineering or regenerative medicine, cardiovascular implants, dental niches, drug carriers, orthopedic interventions, cancer therapy, skin tendon healing, lastly medical tools / equipment. demonstrated instrumental importance three-dimensionally (3D) printable biopolymer, which further been bolstered by its role during the Coronavirus Disease 2019 (Covid-19) global pandemic. As an filament, created desperately needed personal protective equipment (PPE) ventilator modifications. polymer chemistry continues to advance, so too will continued efficacy PLA-based modalities.

Language: Английский

Citations

401
Biodegradable Materials and Metallic Implants—A Review DOI Creative Commons
Mythili Prakasam, Jānis Ločs, Kristīne Šalma-Ancāne

et al.

Journal of Functional Biomaterials, Journal Year: 2017, Volume and Issue: 8(4), P. 44 - 44

Published: Sept. 26, 2017

Recent progress made in biomaterials and their clinical applications is well known. In the last five decades, great advances have been field of biomaterials, including ceramics, glasses, polymers, composites, glass-ceramics metal alloys. A variety bioimplants are currently used either one aforesaid forms. Some these materials designed to degrade or be resorbed inside body rather than removing implant after its function served. Many properties such as mechanical properties, non-toxicity, surface modification, degradation rate, biocompatibility, corrosion rate scaffold design taken into consideration. The current review focuses on state-of-the-art biodegradable bioceramics, alloys a few implants that employ bioresorbable/biodegradable materials. essential functions, critical factors discussed detail, addition challenges overcome.

Language: Английский

Citations

392
Current advances and future perspectives of 3D printing natural-derived biopolymers DOI
Jun Liu, Lushan Sun, Wenyang Xu

et al.

Carbohydrate Polymers, Journal Year: 2018, Volume and Issue: 207, P. 297 - 316

Published: Nov. 24, 2018

Language: Английский

Citations

347
Characterization of printed PLA scaffolds for bone tissue engineering DOI Open Access

Agathe Grémare,

Vera Gudurić, Reine Bareille

et al.

Journal of Biomedical Materials Research Part A, Journal Year: 2017, Volume and Issue: 106(4), P. 887 - 894

Published: Nov. 6, 2017

Abstract Autografts remain the gold standard for orthopedic transplantations. However, to overcome its limitations, bone tissue engineering proposes new strategies. This includes development of biomaterials such as synthetic polymers, serve scaffold production. The objective this present study was produce poly(lactic) acid (PLA) scaffolds different pore size using fused deposition modeling (FDM) technique and evaluate their physicochemical biological properties. Structural, chemical, mechanical, characterizations were performed. We successfully fabricated three sizes. dimensions slightly smaller than expected. found that 3D printing process induced decreases in both, PLA molecular weight degradation temperatures, but did not change semicrystalline structure polymer. observe any effect on mechanical properties produced scaffolds. After sterilization by γ irradiation, exhibit cytotoxicity towards human marrow stromal cells (HBMSC). Finally, after seven days culture, HBMSC showed high viability homogenous distribution irrespective size. Thus, these results suggest FDM technology is a fast reproducible can be used fabricate tridimensional custom‐made engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 887–894, 2018.

Language: Английский

Citations

297
Advances and limitations of drug delivery systems formulated as eye drops DOI Creative Commons

Clotilde Jumelle,

Shima Gholizadeh,

Nasim Annabi

et al.

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 321, P. 1 - 22

Published: Feb. 3, 2020

Language: Английский

Citations

281