Materials Today, Journal Year: 2022, Volume and Issue: 63, P. 137 - 169
Published: Nov. 17, 2022
Language: Английский
Drug Delivery and Translational Research, Journal Year: 2021, Volume and Issue: 12(4), P. 758 - 791
Published: Jan. 20, 2021
Abstract Transdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed products global market. The use these can overcome associated drawbacks other routes, such as oral parenteral. authors will review current trends, future applications transdermal technologies, with specific focus on providing a comprehensive understanding enhancement strategies. This article initially discuss each method used development first-generation products. These methods include drug/vehicle interactions, vesicles particles, stratum corneum modification, energy-driven bypassing techniques. Through suitable design implementation active methods, notably microneedle technology, been shown to deliver both low high molecular weight drugs. Microneedle platforms proven themselves be more versatile than opportunities for intradermal drugs/biotherapeutics therapeutic monitoring. that microneedles prospective strategy improving systems. Graphical abstract
Language: Английский
Citations
388
Advanced Materials, Journal Year: 2020, Volume and Issue: 32(33)
Published: June 29, 2020
Abstract Skin infections caused by bacteria, viruses and fungi are difficult to treat conventional topical administration because of poor drug penetration across the stratum corneum. This results in low bioavailability drugs infection site, as well lack prolonged release. Emerging antimicrobial transdermal ocular microneedle patches have become promising medical devices for delivery various antibacterial, antifungal, antiviral therapeutics. In present review, skin anatomy its barriers along with discussed. Potential strategies designing microneedles their targeted therapy outlined. Finally, biosensing associated personalized selective toxicity toward specific microbial species
Language: Английский
Citations
356
Obstetrics and Gynecology Clinics of North America, Journal Year: 2021, Volume and Issue: 48(4), P. 723 - 735
Published: Oct. 29, 2021
Language: Английский
Citations
319
ACS Nano, Journal Year: 2020, Volume and Issue: 14(5), P. 5901 - 5908
Published: April 21, 2020
Oxygen carriers are attracting extensive interest in biomedical research and clinical applications such as wound healing, alternative blood transfusion, acute trauma treatment. Great efforts have been devoted to the generation of oxygen with special functions properties meet specific demands. Here, we present black phosphorus (BP)-loaded separable responsive microneedles (MNs) carrying controllable delivering ability for healing. Such MNs composed a polyvinyl acetate (PVA) backing layer gelatin methacryloyl (GelMA) tips that loaded BP quantum dots (BP QDs) hemoglobin (Hb). Taking advantage fast dissolvability PVA, soon disappears after applied skin noncytotoxic, biocompatible GelMA left inside skin. Due excellent photothermal effect QDs reversible binding property Hb, local temperature will increase near-infrared ray irradiation, resulting release. Notably, practical performance has demonstrated by treating full-thickness cutaneous wounds type I diabetes rat model, indicating their potential value healing other related fields.
Language: Английский
Citations
296
Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 13(1)
Published: March 16, 2021
Abstract Transdermal microneedle (MN) patches are a promising tool used to transport wide variety of active compounds into the skin. To serve as substitute for common hypodermic needles, MNs must pierce human stratum corneum (~ 10 20 µm), without rupturing or bending during penetration. This ensures that cargo is released at predetermined place and time. Therefore, ability MN sufficiently skin crucial requirement. In current review, pain signal its management application typical needles presented compared. followed by discussion on mechanical analysis models insertion tests before clinical practice. Factors affect (e.g., geometry, material composition cross-linking MNs), along with recent advancements in developed strategies responsive 3D printed biomimetic using two-photon lithography) improve penetration highlighted provide backdrop future research.
Language: Английский
Citations
289
Journal of Pharmaceutical Investigation, Journal Year: 2021, Volume and Issue: 51(5), P. 503 - 517
Published: March 4, 2021
Transdermal delivery has the advantage of bypassing first-pass effect and allowing sustained release drug. However, drug is limited owing to barrier created by stratum corneum. Microneedles are a transdermal system that painless, less invasive, easy self-administer, with high bioavailability. The dose, rate, efficacy drugs can be controlled microneedle design formulations. This review introduces types microneedles their design, materials used for fabrication, manufacturing methods. Additionally, recent biological applications clinical trials introduced. With advancements made in formulation technologies, drug-loading capability improved. 3D printing digital technology contribute improvement fabrication technology. regulations regarding manufacture products should established as soon possible promote commercialization.
Language: Английский
Citations
269
European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2020, Volume and Issue: 159, P. 44 - 76
Published: Dec. 24, 2020
Language: Английский
Citations
223
Advanced Materials, Journal Year: 2019, Volume and Issue: 32(1)
Published: Nov. 4, 2019
The use of microneedles has facilitated the painless localized delivery drugs across skin. However, their efficacy been limited by slow diffusion molecules and often requires external triggers. Herein, an autonomous degradable, active microneedle platform is introduced, employing magnesium microparticles loaded within patch, as built-in engine for deeper faster intradermal payload delivery. particles react with interstitial fluid, leading to explosive-like rapid production H2 bubbles, providing necessary force breach dermal barriers enhance release kinetics evaluated in vitro measuring amount IgG antibody (as a model drug) that passed through phantom tissue pigskin barrier. In vivo experiments using B16F10 mouse melanoma demonstrate anti-CTLA-4 (a checkpoint inhibitor results greatly enhanced immune response significantly longer survival. Moreover, spatially resolved zones passive allow combinatorial burst along slow, sustained release, respectively. Such versatile effective dynamic technology offers considerable promise wide range therapeutic applications, toward outcome, convenience, cost.
Language: Английский
Citations
208
Advanced Healthcare Materials, Journal Year: 2020, Volume and Issue: 9(4)
Published: Jan. 20, 2020
Abstract Skin interstitial fluid (ISF) holds great potential as a highly desirable sample resource for point‐of‐care testing (POCT), where the key is to effectively collect target biomarkers from ISF. Hydrogel microneedle patch has promise ISF extraction. However, it challenging recover extracted skin in hydrogel patches an easy‐administrated, fast, and bulky instrument‐free manner. Herein, made of polyvinyl alcohol (PVA) chitosan (CS) POCT based on developed. The phase transition property PVA/CS makes microneedles stiff when dry, which beneficial easily penetrate into skin. Meanwhile, porous microstructure offers good swelling ability extraction thermal degradation PVA convenient quickly efficiently patch. capability this platform applications further demonstrated by successful detections typical collected mimetic monitoring glucose level rabbit skins during day. developed advantages recovery biomarkers, thus presenting powerful ISF‐based applications.
Language: Английский
Citations
203
Science Advances, Journal Year: 2019, Volume and Issue: 5(11)
Published: Nov. 1, 2019
An effervescent microneedle patch has been designed for rapid separation of drug-loaded microneedles and long-term contraception.
Language: Английский
Citations
198