Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 14(1)

Published: Dec. 2, 2021

Abstract Conductive biomaterials based on conductive polymers, carbon nanomaterials, or inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity human skin, good antioxidant antibacterial activities, electrically controlled drug delivery, photothermal effect. However, a review highlights design application of for engineering is lacking. In this review, fabrication methods with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, acellular dermal matrix applications corresponding mechanism promoting process were summarized. The approaches that realize their value wounds via three main strategies (electrotherapy, dressing, assessment) reviewed. as dressing when facing different acute chronic (infected diabetic wound) monitoring discussed detail. challenges perspectives designing developing multifunctional are proposed well.

Language: Английский

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Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Cells, Journal Year: 2022, Volume and Issue: 11(15), P. 2439 - 2439

Published: Aug. 6, 2022

Wound healing is highly specialized dynamic multiple phase process for the repair of damaged/injured tissues through an intricate mechanism. Any failure in normal wound results abnormal scar formation, and chronic state which more susceptible to infections. Chronic wounds affect patients' quality life along with increased morbidity mortality are huge financial burden healthcare systems worldwide, thus requires biomedical intensive treatment its management. The clinical assessment management remains challenging despite development various therapeutic regimens owing painstakingly long-term requirement complex Various conventional approaches such as cell therapy, gene growth factor delivery, dressings, skin grafts etc., being utilized promoting different types wounds. However, all these abovementioned therapies not satisfactory types, therefore, there urgent demand competitive therapies. Therefore, a pertinent develop newer innovative modalities multipart Recent developments advanced care technology includes nanotherapeutics, stem cells bioengineered grafts, 3D bioprinting-based strategies improving outcomes focus on regeneration minimal side effects. main objective this review provide updated overview progress options over years using next generation approaches. Herein, we have discussed function anatomy, processes, followed by regeneration. Furthermore, emerging bioprinted skin, extracellular matrix-based approaches, platelet-rich plasma-based cold plasma therapy been their benefits shortcomings. Finally, challenges reviewed note future prospects.

Language: Английский

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Challenges With the Development of Biomaterials for Sustainable Tissue Engineering

Frontiers in Bioengineering and Biotechnology, Journal Year: 2019, Volume and Issue: 7

Published: May 31, 2019

The field of tissue engineering has tantalizingly offered the possibility regenerating new in order to treat a multitude diseases and conditions within human body. Nevertheless, spite significant progress with vitro small animal studies, toward realizing clinical commercial endpoints been slow many would argue that ultimate goals, especially treating those which, as yet, do not have acceptable conventional therapies, may never be reached because flawed scientific rationale. In other words, sustainable achievable current approaches. One major factors here is choice biomaterial intended, through its use "scaffold," guide regeneration process. For years, effective specifications for these biomaterials well-articulated, requirements biodegradability prior FDA approval medical devices, dominated material selection processes. This essay argues considerations are only wrong principle but counter-productive practice. Materials, such synthetic bioabsorbable polymers, which designed no biological activity could stimulate target cells express appropriate tissue, will effective. It argued traditional 'scaffold' represents approach, tissue-engineering templates replicate niche, or microenvironment, much more likely succeed.

Language: Английский

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Dual-responsive injectable hydrogels encapsulating drug-loaded micelles for on-demand antimicrobial activity and accelerated wound healing

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 324, P. 204 - 217

Published: May 7, 2020

Language: Английский

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A review of fabrication polymer scaffolds for biomedical applications using additive manufacturing techniques

Journal of Applied Biomedicine, Journal Year: 2020, Volume and Issue: 40(2), P. 624 - 638

Published: Feb. 20, 2020

Language: Английский

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Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing

Biomaterials, Journal Year: 2022, Volume and Issue: 285, P. 121479 - 121479

Published: April 14, 2022

Language: Английский

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The applied anatomy of human skin: A model for regeneration

Wound Medicine, Journal Year: 2020, Volume and Issue: 28, P. 100179 - 100179

Published: Jan. 18, 2020

Autologous keratinocyte cultures and combinations of scaffolds, different cell types, solutions macromolecules, or growth factors have contributed to the resurfacing burns large wounds. There are, however, significant limitations with these therapies. No tissue-engineered substitute can fully replace split-thickness skin graft for permanent coverage full-thickness loss in one step, none contain a functional vascular plexus. Current research characterizes as more than barrier sensory function, but an intricate biological factory participating signaling, metabolism, protein synthesis, vital component nervous, immune endocrine systems. This paper provides comprehensive review structure function skin, highlighting importance regenerating organ that will physiologically.

Language: Английский

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Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15962 - 15977

Published: Aug. 3, 2023

Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic carbon nitride nanosheets (ACPCAH). This possesses five types enzyme-like activities, including superoxide dismutase (SOD)-, catalase (CAT)-, glucose oxidase (GOx)-, peroxidase (POD)-, nitric oxide synthase (NOS)-like activities. The kinetics reaction mechanism sonodynamic/sonothermal synergistic enhancement SOD-CAT-GOx-POD/NOS cascade ACPCAH are fully investigated. Both in vitro vivo tests demonstrate that this can be activated thus accelerating wound healing effectively. study highlights a competitive approach based on nanozymes for development all-in-one therapies.

Language: Английский

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Engineering Bioactive Scaffolds for Skin Regeneration

Small, Journal Year: 2021, Volume and Issue: 17(41)

Published: July 26, 2021

Abstract Large skin wounds pose a major clinical challenge. Scarcity of donor site and postsurgical scarring contribute to the incomplete or partial loss function aesthetic concerns in wound patients. Currently, wide variety grafts are being applied settings. Scaffolds used overcome issues related misaligned architecture repaired tissues. The current review summarizes contribution biomaterials healing regeneration addresses existing limitations grafting. Then, clinically approved biologic synthetic substitutes extensively reviewed. Next, techniques for modification aiming enhanced tissue outlined, summary different growth factor delivery systems using is presented. Considering significant progress biomaterial science manufacturing technologies, idea biomaterial‐based with ability scarless reconstructing full organ more achievable than ever.

Language: Английский

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Recent prospects on phosphor-converted LEDs for lighting, displays, phototherapy, and indoor farming

Journal of Luminescence, Journal Year: 2021, Volume and Issue: 237, P. 118167 - 118167

Published: April 30, 2021

Language: Английский

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