Science China Chemistry, Journal Year: 2022, Volume and Issue: 65(11), P. 2238 - 2251
Published: Sept. 13, 2022
Language: Английский
Science China Chemistry, Journal Year: 2022, Volume and Issue: 65(11), P. 2238 - 2251
Published: Sept. 13, 2022
Language: Английский
Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 14(1)
Published: Dec. 2, 2021
Abstract Conductive biomaterials based on conductive polymers, carbon nanomaterials, or inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity human skin, good antioxidant antibacterial activities, electrically controlled drug delivery, photothermal effect. However, a review highlights design application of for engineering is lacking. In this review, fabrication methods with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, acellular dermal matrix applications corresponding mechanism promoting process were summarized. The approaches that realize their value wounds via three main strategies (electrotherapy, dressing, assessment) reviewed. as dressing when facing different acute chronic (infected diabetic wound) monitoring discussed detail. challenges perspectives designing developing multifunctional are proposed well.
Language: Английский
Citations
688Cells, Journal Year: 2022, Volume and Issue: 11(15), P. 2439 - 2439
Published: Aug. 6, 2022
Wound healing is highly specialized dynamic multiple phase process for the repair of damaged/injured tissues through an intricate mechanism. Any failure in normal wound results abnormal scar formation, and chronic state which more susceptible to infections. Chronic wounds affect patients' quality life along with increased morbidity mortality are huge financial burden healthcare systems worldwide, thus requires biomedical intensive treatment its management. The clinical assessment management remains challenging despite development various therapeutic regimens owing painstakingly long-term requirement complex Various conventional approaches such as cell therapy, gene growth factor delivery, dressings, skin grafts etc., being utilized promoting different types wounds. However, all these abovementioned therapies not satisfactory types, therefore, there urgent demand competitive therapies. Therefore, a pertinent develop newer innovative modalities multipart Recent developments advanced care technology includes nanotherapeutics, stem cells bioengineered grafts, 3D bioprinting-based strategies improving outcomes focus on regeneration minimal side effects. main objective this review provide updated overview progress options over years using next generation approaches. Herein, we have discussed function anatomy, processes, followed by regeneration. Furthermore, emerging bioprinted skin, extracellular matrix-based approaches, platelet-rich plasma-based cold plasma therapy been their benefits shortcomings. Finally, challenges reviewed note future prospects.
Language: Английский
Citations
287Frontiers in Bioengineering and Biotechnology, Journal Year: 2019, Volume and Issue: 7
Published: May 31, 2019
The field of tissue engineering has tantalizingly offered the possibility regenerating new in order to treat a multitude diseases and conditions within human body. Nevertheless, spite significant progress with vitro small animal studies, toward realizing clinical commercial endpoints been slow many would argue that ultimate goals, especially treating those which, as yet, do not have acceptable conventional therapies, may never be reached because flawed scientific rationale. In other words, sustainable achievable current approaches. One major factors here is choice biomaterial intended, through its use "scaffold," guide regeneration process. For years, effective specifications for these biomaterials well-articulated, requirements biodegradability prior FDA approval medical devices, dominated material selection processes. This essay argues considerations are only wrong principle but counter-productive practice. Materials, such synthetic bioabsorbable polymers, which designed no biological activity could stimulate target cells express appropriate tissue, will effective. It argued traditional 'scaffold' represents approach, tissue-engineering templates replicate niche, or microenvironment, much more likely succeed.
Language: Английский
Citations
261Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 324, P. 204 - 217
Published: May 7, 2020
Language: Английский
Citations
215Journal of Applied Biomedicine, Journal Year: 2020, Volume and Issue: 40(2), P. 624 - 638
Published: Feb. 20, 2020
Language: Английский
Citations
214Biomaterials, Journal Year: 2022, Volume and Issue: 285, P. 121479 - 121479
Published: April 14, 2022
Language: Английский
Citations
148Wound Medicine, Journal Year: 2020, Volume and Issue: 28, P. 100179 - 100179
Published: Jan. 18, 2020
Autologous keratinocyte cultures and combinations of scaffolds, different cell types, solutions macromolecules, or growth factors have contributed to the resurfacing burns large wounds. There are, however, significant limitations with these therapies. No tissue-engineered substitute can fully replace split-thickness skin graft for permanent coverage full-thickness loss in one step, none contain a functional vascular plexus. Current research characterizes as more than barrier sensory function, but an intricate biological factory participating signaling, metabolism, protein synthesis, vital component nervous, immune endocrine systems. This paper provides comprehensive review structure function skin, highlighting importance regenerating organ that will physiologically.
Language: Английский
Citations
147ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15962 - 15977
Published: Aug. 3, 2023
Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic carbon nitride nanosheets (ACPCAH). This possesses five types enzyme-like activities, including superoxide dismutase (SOD)-, catalase (CAT)-, glucose oxidase (GOx)-, peroxidase (POD)-, nitric oxide synthase (NOS)-like activities. The kinetics reaction mechanism sonodynamic/sonothermal synergistic enhancement SOD-CAT-GOx-POD/NOS cascade ACPCAH are fully investigated. Both in vitro vivo tests demonstrate that this can be activated thus accelerating wound healing effectively. study highlights a competitive approach based on nanozymes for development all-in-one therapies.
Language: Английский
Citations
135Small, Journal Year: 2021, Volume and Issue: 17(41)
Published: July 26, 2021
Abstract Large skin wounds pose a major clinical challenge. Scarcity of donor site and postsurgical scarring contribute to the incomplete or partial loss function aesthetic concerns in wound patients. Currently, wide variety grafts are being applied settings. Scaffolds used overcome issues related misaligned architecture repaired tissues. The current review summarizes contribution biomaterials healing regeneration addresses existing limitations grafting. Then, clinically approved biologic synthetic substitutes extensively reviewed. Next, techniques for modification aiming enhanced tissue outlined, summary different growth factor delivery systems using is presented. Considering significant progress biomaterial science manufacturing technologies, idea biomaterial‐based with ability scarless reconstructing full organ more achievable than ever.
Language: Английский
Citations
130Journal of Luminescence, Journal Year: 2021, Volume and Issue: 237, P. 118167 - 118167
Published: April 30, 2021
Language: Английский
Citations
121