Structural and biological engineering of 3D hydrogels for wound healing

Bioactive Materials, Journal Year: 2022, Volume and Issue: 24, P. 197 - 235

Published: Dec. 23, 2022

Chronic wounds have become one of the most important issues for healthcare systems and are a leading cause death worldwide. Wound dressings necessary to facilitate wound treatment. Engineering may substantially reduce healing time, risk recurrent infections, disability costs associated. In path engineering an ideal dressing, hydrogels played role. Hydrogels 3D hydrophilic polymeric structures that can provide protective barrier, mimic native extracellular matrix (ECM), humid environment. Due their advantages, (with different architectural, physical, mechanical, biological properties) been extensively explored as dressing platforms. Here we describe recent studies on applications with strong focus interplay between fabrication method used performance achieved. Moreover, review categories additives which enhance regeneration using hydrogel dressings. Hydrogel promises generation smart solutions solve this pressing problem, enabling key functionalities such bacterial growth inhibition, enhanced re-epithelialization, vascularization, improved recovery tissue functionality, overall, accelerated effective healing.

Language: Английский

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Hydrogels for Flexible Electronics

ACS Nano, Journal Year: 2023, Volume and Issue: 17(11), P. 9681 - 9693

Published: May 18, 2023

Hydrogels have emerged as promising materials for flexible electronics due to their unique properties, such high water content, softness, and biocompatibility. In this perspective, we provide an overview of the development hydrogels electronics, with a focus on three key aspects: mechanical interfacial adhesion, conductivity. We discuss principles designing high-performance present representative examples potential applications in field healthcare. Despite significant progress, several challenges remain, including improving antifatigue capability, enhancing balancing content wet environments. Additionally, highlight importance considering hydrogel-cell interactions dynamic properties future research. Looking ahead, is promising, exciting opportunities horizon, but continued investment research necessary overcome remaining challenges.

Language: Английский

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Bacterial infection microenvironment‐responsive porous microspheres by microfluidics for promoting anti‐infective therapy

Smart Medicine, Journal Year: 2022, Volume and Issue: 1(1)

Published: Dec. 1, 2022

The overuse of antibiotics for treating bacterial infection has caused severe resistance and become a public health threat worldwide. It is desired to develop novel antibiotic delivery systems as efficient antibacterial strategies promoting anti-infective therapy. Herein, the AgNPs-loaded

Language: Английский

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Conductive Hydrogel for Flexible Bioelectronic Device: Current Progress and Future Perspective

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(1)

Published: Sept. 19, 2023

Abstract Conductive hydrogels (CHs) for flexible bioelectronic devices have raised great attention due to their tunable mechanical performances, adhesion, anti‐swelling, and biocompatibility. This review summarizes the current development of conductive hydrogel‐based in aspect classifications applications. Firstly, are classified into two kinds according types conductivity: ionic electronic (hydrogel based on pure materials, introducing micro/nano‐materials). Secondly, applications device, like wearable (strain sensor, body fluid detector, serviced extreme environment), tissue engineering (skin, heart, nerve, muscle), other (bionic robot, cancer treatment), highly illustrated. Finally, a depth outlook is given, which aims promote this field future.

Language: Английский

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Conductive hydrogels for tissue repair

Chemical Science, Journal Year: 2023, Volume and Issue: 14(12), P. 3091 - 3116

Published: Jan. 1, 2023

This work reviewed the new progress of conductive hydrogels in application tissue repair and provided a useful reference for further preparation safer more efficient engineering.

Language: Английский

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Injectable, self-healing, transparent, and antibacterial hydrogels based on chitosan and dextran for wound dressings

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 233, P. 123494 - 123494

Published: Feb. 1, 2023

Language: Английский

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Wound management materials and technologies from bench to bedside and beyond

Nature Reviews Materials, Journal Year: 2024, Volume and Issue: 9(8), P. 550 - 566

Published: June 17, 2024

Language: Английский

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Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(10)

Published: Jan. 1, 2023

Abstract Diabetic foot ulcer (DFU) is one of the most common complications diabetes, bringing physical and mental challenges for patients due to lack efficient curative therapy. Despite considerable advances in pharmacological surgical approaches, clinical trials DFU remain disappointing local overactive excessive inflammation. Immunomodulatory hydrogels has significant advantages overcome challenge DFUs Here, recent fabrication regenerative utilization functional altering immune microenvironment are comprehensively reviewed. The pathological features healing processes DFUs, followed by summarizing physicochemical properties essential design immunomodulation briefly introduced. Then, potential immuno‐therapeutic modalities emerging trends used treat via multitherapeutic approaches enhanced efficacy safety discussed. Taken together, linking structural their functions therapy with a particular focus on immunomodulatory stimuli, this review can promote further designing advanced resulting improved diabetic wound repair through translation into setting near future.

Language: Английский

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Recent advances in decellularized biomaterials for wound healing

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100589 - 100589

Published: Feb. 23, 2023

The skin is one of the most essential organs in human body, interacting with external environment and shielding body from diseases excessive water loss. Thus, loss integrity large portions due to injury illness may lead significant disabilities even death. Decellularized biomaterials derived extracellular matrix tissues are natural quantities bioactive macromolecules peptides, which possess excellent physical structures sophisticated biomolecules, thus, promote wound healing regeneration. Here, we highlighted applications decellularized materials repair. First, wound-healing process was reviewed. Second, elucidated mechanisms several constitutes facilitating healing. Third, major categories treatment cutaneous wounds numerous preclinical models over decades clinical practice were elaborated. Finally, discussed current hurdles field anticipated future challenges novel avenues for research on biomaterials-based treatment.

Language: Английский

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Bioadhesive Technology Platforms

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(24), P. 14084 - 14118

Published: Nov. 16, 2023

Bioadhesives have emerged as transformative and versatile tools in healthcare, offering the ability to attach tissues with ease minimal damage. These materials present numerous opportunities for tissue repair biomedical device integration, creating a broad landscape of applications that captivated clinical scientific interest alike. However, fully unlocking their potential requires multifaceted design strategies involving optimal adhesion, suitable biological interactions, efficient signal communication. In this Review, we delve into these pivotal aspects bioadhesive design, highlight latest advances applications, identify lie ahead bioadhesives multifunctional technology platforms.

Language: Английский

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