Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: March 29, 2024
Abstract
The
deployment
of
imaging
examinations
has
evolved
into
a
robust
approach
for
the
diagnosis
lymph
node
metastasis
(LNM).
advancement
technology,
coupled
with
introduction
innovative
drugs,
led
to
incorporation
an
increasingly
diverse
array
techniques
clinical
practice.
Nonetheless,
conventional
methods
administering
agents
persist
in
presenting
certain
drawbacks
and
side
effects.
employment
controlled
drug
delivery
systems
(DDSs)
as
conduit
transporting
offers
promising
solution
ameliorate
these
limitations
intrinsic
metastatic
(LN)
imaging,
thereby
augmenting
diagnostic
precision.
Within
scope
this
review,
we
elucidate
historical
context
LN
encapsulate
frequently
employed
DDSs
conjunction
variety
techniques,
specifically
imaging.
Moreover,
engage
discourse
on
conceptualization
practical
application
fusing
treatment
by
employing
DDSs.
Finally,
venture
prospective
applications
realm
LNM
share
our
perspective
potential
trajectory
DDS
development.
Graphical
Journal of Clinical Investigation,
Journal Year:
2022,
Volume and Issue:
132(6)
Published: March 14, 2022
The
COVID-19
pandemic
has
elevated
mRNA
vaccines
to
global
recognition
due
their
unprecedented
success
rate
in
protecting
against
a
deadly
virus.
This
international
is
underscored
by
the
remarkable
versatility,
favorable
immunogenicity,
and
overall
safety
of
platform
diverse
populations.
Although
have
been
studied
preclinical
models
patients
with
cancer
for
almost
three
decades,
development
slow.
recent
technological
advances
responsible
potential
implications
successfully
adapting
this
vaccine
therapeutics.
Here
we
discuss
lessons
learned
along
chemical,
biologic,
immunologic
adaptations
needed
optimize
technology
treat
cancers.
Medicine in Drug Discovery,
Journal Year:
2023,
Volume and Issue:
20, P. 100165 - 100165
Published: Oct. 30, 2023
Among
all
diseases,
cancer
has
the
highest
fatality
rate
in
world.
Conventional
therapies
have
come
a
long
way,
but
they
still
are
not
panacea
for
cancer.
Nanotechnology-based
compositions
of
several
nanoparticles
(NPs)
hold
promise
as
therapy.
The
co-delivery
amphiphilic
molecules
is
feasible
with
lipid-polymer
hybrid
(LPHNPs).
Increased
encapsulation
pharmaceuticals
regulated
release
profile
made
possible
by
physical
benefits
polymers
and
resembling
features
lipids.
For
increased
cytotoxicity
against
cancer,
LPHNPs
been
created
co-transport
phytochemicals
other
chemotherapeutic
medicines.
Specifically,
used
carrier
systems
to
deliver
drugs
tumour
locations
fashion.
This
method
makes
use
biocompatibility
lipids
structural
advantages
provide
controlled
drug
administration.
Co-loaded
demonstrated
improved
cytotoxicity,
incorporation
into
various
medications
resulted
enhanced
chemo-sensitization
carcinomas.
shortcomings
existing
nano-delivery
discussed
this
review.
Biomaterials Research,
Journal Year:
2023,
Volume and Issue:
27(1)
Published: Feb. 9, 2023
With
the
great
success
of
coronavirus
disease
(COVID-19)
messenger
ribonucleic
acid
(mRNA)
vaccines,
mRNA
therapeutics
have
gained
significant
momentum
for
prevention
and
treatment
various
refractory
diseases.
To
function
efficiently
in
vivo
overcome
clinical
limitations,
demands
safe
stable
vectors
a
reasonable
administration
route,
bypassing
multiple
biological
barriers
achieving
organ-specific
targeted
delivery
mRNA.
Nanoparticle
(NP)-based
systems
representing
leading
vector
approaches
ensure
successful
intracellular
to
target
organ.
In
this
review,
chemical
modifications
types
advanced
NPs,
including
lipid
NPs
polymers
are
summarized.
The
importance
passive
targeting,
especially
endogenous
active
targeting
nano-delivery
is
emphasized,
different
cellular
endocytic
mechanisms
discussed.
Most
importantly,
based
on
above
content
physiological
structure
characteristics
organs
vivo,
design
strategies
cells
classified
Furthermore,
influence
routes
highlighted.
Finally,
an
outlook
remaining
challenges
future
development
toward
therapies
precision
medicine
provided.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
36, P. 330 - 357
Published: March 11, 2024
Nanovaccines
have
gathered
significant
attention
for
their
potential
to
elicit
tumor-specific
immunological
responses.
Despite
notable
progress
in
tumor
immunotherapy,
nanovaccines
still
encounter
considerable
challenges
such
as
low
delivery
efficiency,
limited
targeting
ability,
and
suboptimal
efficacy.
With
an
aim
of
addressing
these
issues,
engineering
customized
through
modification
or
functionalization
has
emerged
a
promising
approach.
These
tailored
not
only
enhance
antigen
presentation,
but
also
effectively
modulate
immunosuppression
within
the
microenvironment.
Specifically,
they
are
distinguished
by
diverse
sizes,
shapes,
charges,
structures,
unique
physicochemical
properties,
along
with
ligands.
features
facilitate
lymph
node
accumulation
activation/regulation
immune
cells.
This
overview
bespoke
underscores
both
prophylactic
therapeutic
applications,
offering
insights
into
future
development
role
cancer
immunotherapy.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: March 29, 2024
Abstract
The
deployment
of
imaging
examinations
has
evolved
into
a
robust
approach
for
the
diagnosis
lymph
node
metastasis
(LNM).
advancement
technology,
coupled
with
introduction
innovative
drugs,
led
to
incorporation
an
increasingly
diverse
array
techniques
clinical
practice.
Nonetheless,
conventional
methods
administering
agents
persist
in
presenting
certain
drawbacks
and
side
effects.
employment
controlled
drug
delivery
systems
(DDSs)
as
conduit
transporting
offers
promising
solution
ameliorate
these
limitations
intrinsic
metastatic
(LN)
imaging,
thereby
augmenting
diagnostic
precision.
Within
scope
this
review,
we
elucidate
historical
context
LN
encapsulate
frequently
employed
DDSs
conjunction
variety
techniques,
specifically
imaging.
Moreover,
engage
discourse
on
conceptualization
practical
application
fusing
treatment
by
employing
DDSs.
Finally,
venture
prospective
applications
realm
LNM
share
our
perspective
potential
trajectory
DDS
development.
Graphical
