Royal Society of Chemistry eBooks,
Journal Year:
2025,
Volume and Issue:
unknown, P. 297 - 328
Published: May 7, 2025
The
emergence
of
nanotechnology
has
developed
into
a
multifaceted
field
that
transformed
numerous
fields,
both
scientific
and
non-scientific.
These
fields
include
robotics,
biology,
electrical
mechanical
engineering,
materials
chemistry,
applied
physics,
chemical
mechanics.
Nanomaterials
find
extensive
use
in
the
realms
biomedicine
medicine.
They
are
ideal
for
surface
nano-engineering
manufacturing
modified
nanostructures
given
their
nanometer
size
from
1
to
100
nm.
have
also
been
used
as
drug
delivery
systems
(DDS)
increased
solubility
targeted
site
action.
Currently,
magnetic
nanoparticles
(MNPs)
among
most
readily
manufactured
types
inorganic
nanosystems.
primarily
composed
ferrites,
metal
oxides,
metals,
nanocomposites.
biocompatibility
toxicity
these
nanosystems
influence
advantages
well
disadvantages
biomedical
field.
qualities
make
them
typically
applications,
they
shown
improve
stability
drugs
biological
environment,
increasing
efficacy
against
range
cells
tumors
while
lowering
enhancing
biocompatibility.
Thus,
application
within
this
framework,
with
special
emphasis
on
lipid-based
nanoparticles,
examined.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5842 - 5842
Published: May 27, 2024
This
study
provides
a
brief
discussion
of
the
major
nanopharmaceuticals
formulations
as
well
impact
nanotechnology
on
future
pharmaceuticals.
Effective
and
eco-friendly
strategies
biofabrication
are
also
highlighted.
Modern
approaches
to
designing
pharmaceutical
nanoformulations
(e.g.,
3D
printing,
Phyto-Nanotechnology,
Biomimetics/Bioinspiration,
etc.)
outlined.
paper
discusses
need
use
natural
resources
for
“green”
design
new
with
therapeutic
efficiency.
Nanopharmaceuticals
research
is
still
in
its
early
stages,
preparation
nanomaterials
must
be
carefully
considered.
Therefore,
safety
long-term
effects
not
overlooked.
The
testing
represents
an
essential
point
their
further
applications.
Vegetal
scaffolds
obtained
by
decellularizing
plant
leaves
represent
valuable,
bioinspired
model
nanopharmaceutical
that
avoids
using
animals.
Nanoformulations
critical
various
fields,
especially
pharmacy,
medicine,
agriculture,
material
science,
due
unique
properties
advantages
over
conventional
allows
improved
solubility,
bioavailability,
targeted
drug
delivery,
controlled
release,
reduced
toxicity.
have
transitioned
from
experimental
stages
being
vital
component
clinical
practice,
significantly
improving
outcomes
medical
fields
cancer
treatment,
infectious
diseases,
neurological
disorders,
personalized
advanced
diagnostics.
Here
key
points
highlighting
importance.
significant
challenges,
opportunities,
directions
mentioned
final
section.
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(2), P. e42013 - e42013
Published: Jan. 1, 2025
The
issue
of
antimicrobial
resistance
(AMR)
poses
a
major
challenge
to
global
health,
evidenced
by
alarming
mortality
predictions
and
the
diminishing
efficiency
conventional
drugs.
CRISPR-Cas
system
has
proven
be
powerful
tool
in
addressing
this
challenge.
It
originated
from
bacterial
adaptive
immune
mechanisms
gained
significant
recognition
scientific
community.
This
review
aims
explore
applications
technologies
combating
AMR,
evaluating
their
effectiveness,
challenges,
potential
for
integration
into
current
strategies.
We
conducted
comprehensive
recent
literature
databases
such
as
PubMed
Web
Science,
focusing
on
studies
that
employ
against
AMR.
offer
transformative
approach
combat
with
extend
beyond
traditional
Integrating
these
existing
methods
could
significantly
enhance
our
ability
manage
potentially
reverse
growing
problem
resistance.
Future
research
should
address
technical
ethical
barriers
facilitate
safe
effective
clinical
environmental
applications.
underscores
necessity
interdisciplinary
collaboration
international
cooperation
harness
full
fight
superbugs.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Abstract
The
advent
of
Clustered
Regularly
Interspaced
Short
Palindromic
Repeats
(CRISPR)‐based
genome
editing
technologies
has
opened
up
groundbreaking
possibilities
for
treating
a
wide
spectrum
genetic
disorders
and
diseases.
However,
the
success
these
relies
heavily
on
development
efficient
safe
delivery
systems.
Among
most
promising
approaches
are
natural
synthetic
nanocarrier‐mediated
systems,
including
viral
vectors,
extracellular
vesicles
(EVs),
engineered
cellular
membrane
particles,
liposomes,
various
nanoparticles.
These
carriers
enhance
efficacy
CRISPR
system
by
providing
unique
combination
efficiency,
specificity,
reduced
immunogenicity.
Synthetic
such
as
liposomes
nanoparticles
facilitate
with
high
reproducibility
customizable
functions.
Viral
renowned
their
transduction
efficiency
broad
tropism,
serve
powerful
vehicles
delivering
components
to
cell
types.
EVs,
RNA
proteins,
offer
stealth
mechanism
evade
immune
detection,
allowing
targeted
editors
minimal
off‐target
effects.
Engineered
particles
further
improve
simulating
environment,
enhancing
uptake,
minimizing
response.
This
review
explores
innovative
integration
nanocarrier
focusing
recent
advancements,
applications,
future
directions
in
therapeutic
editing.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1739 - 1739
Published: Feb. 1, 2024
Single-stranded
messenger
ribonucleic
acid
(mRNA)
plays
a
pivotal
role
in
transferring
genetic
information,
and
tremendous
effort
has
been
devoted
over
the
years
to
utilize
its
transcription
efficacy
therapeutic
interventions
for
variety
of
diseases
with
high
morbidity
mortality.
Lipid
nanocarriers
have
extensively
investigated
mRNA
delivery
enabled
rapid
successful
development
vaccines
against
SARS-CoV-2.
Some
constraints
lipid
encouraged
alternative
systems,
such
as
polymer-based
soft
nanoparticles,
which
offer
modular
gene
platform.
Such
macromolecule-based
can
be
synthetically
articulated
tailored
parameters
including
protection,
loading
efficacy,
targeted
release.
In
this
review,
we
highlight
recent
advances
polymeric
architectures
delivery,
their
limitations,
challenges
that
still
exist,
aim
expediting
further
research
clinical
translation
formulations.
Advanced Drug Delivery Reviews,
Journal Year:
2024,
Volume and Issue:
208, P. 115291 - 115291
Published: March 19, 2024
Among
non-viral
vectors,
lipid
nanovectors
are
considered
the
gold
standard
for
delivery
of
RNA
therapeutics.
The
success
nanoparticles
delivery,
with
three
products
approved
human
use,
has
stimulated
further
investigation
into
therapeutics
different
pathologies.
This
requires
decoding
pathological
intracellular
processes
and
tailoring
system
to
target
tissue
cells.
complexity
morphology
originates
from
assembling
lipidic
components,
which
can
be
elicited
by
various
methods
able
drive
formation
desired
organization.
In
other
cases,
pre-formed
mixed
induce
self-assembly
structural
reorganization
RNA-loaded
nanoparticles.
this
review,
most
relevant
their
potentialities
described
on
basis
mechanism
particle
architecture.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(8), P. 975 - 975
Published: July 23, 2024
Oxidative
stress,
driven
by
reactive
oxygen,
nitrogen,
and
sulphur
species
(ROS,
RNS,
RSS),
poses
a
significant
threat
to
cellular
integrity
human
health.
Generated
during
mitochondrial
respiration,
inflammation,
UV
exposure
pollution,
these
damage
cells
contribute
pathologies
like
cardiovascular
issues,
neurodegeneration,
cancer,
metabolic
syndromes.
Lifestyle
factors
exert
substantial
influence
on
oxidative
stress
levels,
with
mitochondria
emerging
as
pivotal
players
in
ROS
generation
equilibrium.
Phytochemicals,
abundant
plants,
such
carotenoids,
ascorbic
acid,
tocopherols
polyphenols,
offer
diverse
antioxidant
mechanisms.
They
scavenge
free
radicals,
chelate
metal
ions,
modulate
signalling
pathways
mitigate
damage.
Furthermore,
plants
thriving
high-altitude
regions
are
adapted
extreme
conditions,
synthesize
secondary
metabolites,
flavonoids
phenolic
compounds
bulk
quantities,
which
act
form
robust
defence
against
including
radiation
temperature
fluctuations.
These
promising
sources
for
drug
development,
offering
innovative
strategies
manage
stress-related
ailments
enhance
Understanding
harnessing
the
potential
of
phytochemicals
from
represent
crucial
steps
combating
stress-induced
disorders
promoting
overall
wellbeing.
This
study
offers
comprehensive
summary
production
physio-pathological
aspects
lifestyle-induced
explores
antioxidants.
Additionally,
it
presents
an
appraisal
medicinal
antioxidants,
highlighting
their
development
creation
therapeutic
approaches.
