Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(22)

Published: April 19, 2021

Abstract Polyphenols, the phenolic hydroxyl group‐containing organic molecules, are widely found in natural plants and have shown beneficial effects on human health. Recently, polyphenol‐containing nanoparticles attracted extensive research attention due to their antioxidation property, anticancer activity, universal adherent affinity, thus great promise preparation, stabilization, modification of multifunctional nanoassemblies for bioimaging, therapeutic delivery, other biomedical applications. Additionally, metal−polyphenol networks, formed by coordination interactions between polyphenols metal ions, been used prepare an important class surface modification, drug disease treatments. By focusing different materials (e.g., inorganic materials, polymers, proteins, nucleic acids), a comprehensive review synthesis properties is provided. Moreover, remarkable versatility applications, including biodetection, multimodal protein gene bone repair, antibiosis, cancer theranostics also demonstrated. Finally, challenges faced future regarding discussed.

Language: Английский

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Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

Advanced Science, Journal Year: 2020, Volume and Issue: 8(3)

Published: Dec. 20, 2020

Abstract Reactive oxygen species (ROS) play an essential role in physiological and pathological processes. Studies on the regulation of ROS for disease treatments have caused wide concern, mainly involving topics ROS‐regulating therapy such as antioxidant triggered by scavengers ROS‐induced toxic mediated ROS‐elevation agents. Benefiting from remarkable advances nanotechnology, a large number nanomaterials with ability are developed to seek new effective ROS‐related nanotherapeutic modalities or nanomedicines. Although considerable achievements been made ROS‐based nanomedicines treatments, some fundamental but key questions rational design principle held low regard. Here, can serve initial framework scientists technicians optimize nanomedicines, thereby minimizing gap biomedical application during stage. Herein, overview current progress ROS‐associated is summarized. And then, particularly addressing these known strategies therapy, several principles presented. Finally, future perspectives also discussed depth development

Language: Английский

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Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells

Advanced Science, Journal Year: 2021, Volume and Issue: 8(22)

Published: Oct. 10, 2021

Abstract Ferroptosis is a new form of regulated cell death, which characterized by the iron‐dependent accumulation lethal lipid peroxides and involved in many critical diseases. Recent reports revealed that cellular energy metabolism activities such as glycolysis, pentose phosphate pathway (PPP), tricarboxylic acid cycle are regulation key ferroptosis markers reduced nicotinamide adenine dinucleotide (NADPH), glutathione (GSH), reactive oxygen species (ROS), therefore imposing potential regulatory roles ferroptosis. Remarkably, tumor cells can activate adaptive metabolic responses to inhibit for self‐preservation upregulation glycolysis PPP. Due rapid proliferation intensified rate, has become target disrupting redox homeostasis induce Based on these emerging insights, impact those‐tumor specific aberrations systematically characterized, rewired glucose compensation through glutamine utilization analyzed underlying molecular mechanisms. Additionally, those ferroptosis‐based therapeutic strategies also discussed exploiting vulnerabilities, may open up avenues treatment clinical context.

Language: Английский

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Advances in gelatin-based hydrogels for wound management

Journal of Materials Chemistry B, Journal Year: 2020, Volume and Issue: 9(6), P. 1503 - 1520

Published: Dec. 22, 2020

The normal wound healing process and the foreign body reaction to management materials.

Language: Английский

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Recent advances on endogenous/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 451, P. 214267 - 214267

Published: Nov. 6, 2021

Language: Английский

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Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment

ACS Nano, Journal Year: 2021, Volume and Issue: 15(8), P. 13759 - 13769

Published: July 19, 2021

Androgenetic alopecia (AGA) is highly prevalent in current society but lacks effective treatments. The dysregulation of the hair follicle niche induced by excessive reactive oxygen species (ROS) and insufficient vascularization perifollicular microenvironment leading cause AGA. Herein, we designed a ceria nanozyme (CeNZ)-integrated microneedles patch (Ce-MNs) that can alleviate oxidative stress promote angiogenesis simultaneously to reshape for AGA treatment. On basis excellent mechanical strength Ce-MNs, encapsulated CeNZs with catalase- superoxide-mimic activities be efficiently delivered into skin scavenge ROS. Moreover, stimulation administration MNs remodel microvasculature balding region. Compared minoxidil, widely used clinical drug treatment, Ce-MNs exhibited accelerated regeneration mouse model at lower frequency without inducing significant damage. Consequently, such safe microenvironment-shaping shows great potential

Language: Английский

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ROS-based dynamic therapy synergy with modulating tumor cell-microenvironment mediated by inorganic nanomedicine

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 437, P. 213828 - 213828

Published: March 9, 2021

Language: Английский

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Targeting Endogenous Hydrogen Peroxide at Bone Defects Promotes Bone Repair

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(10)

Published: Dec. 22, 2021

Abstract Reactive oxygen species (ROS) plays a critical role in tissue repair, including bone. Therefore, detecting and regulating ROS is essential for monitoring facilitating bone repair. In this study, the first time, spatiotemporal profile of ROS, represented by hydrogen peroxide (H 2 O ), injury microenvironment using photoacoustic imaging technique visualized. The levels significantly increase upon injury, peak at certain stage healing, then gradually decrease toward baseline level. To regulate microenvironment, use hollow manganese dioxide nanoparticles (hMNPs), which are able to decompose H generate explored. vitro, hMNPs eliminate intracellular protect cells from oxidative damage facilitate cell growth releasing oxygen. vivo, composite hydrogels containing gelatin methacryloyl (GelMA) (hMNP/GelMA) release morphogenetic protein‐2 (BMP‐2)‐associated peptide an “on‐demand” fashion response microenvironmental change. Applying hMNP/GelMA loaded with BMP‐2‐associated (BhMNP/GelMA) enhances formation rat critical‐sized calvarial defect. Together, findings study imply that visualization regulation such as may be novel strategy diagnosing treating defects.

Language: Английский

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Ceria‐Based Therapeutic Antioxidants for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 16, 2023

Abstract The growing interest in nanomedicine over the last 20 years has carved out a research field called “nanocatalytic therapy,” where catalytic reactions mediated by nanomaterials are employed to intervene disease‐critical biomolecular processes. Among many kinds of catalytic/enzyme‐mimetic investigated thus far, ceria nanoparticles stand from others owing their unique scavenging properties against biologically noxious free radicals, including reactive oxygen species (ROS) and nitrogen (RNS), exerting enzyme mimicry nonenzymatic activities. Much effort been made utilize as self‐regenerating antioxidative anti‐inflammatory agents for various diseases, given detrimental effects ROS RNS therein that need alleviation. In this context, review is intended provide an overview what makes merit attention disease therapy. introductory part describes characteristics oxygen‐deficient metal oxide. pathophysiological roles then presented, well mechanisms nanoparticles. Representative examples recent ceria‐nanoparticle‐based therapeutics summarized categorization into organ types, followed discussion on remaining challenges future directions.

Language: Английский

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Metal-Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(16), P. 10135 - 10155

Published: Aug. 3, 2023

Over the last few decades, various forms of regulated cell death (RCD) have been discovered and were found to improve cancer treatment. Although there are several reviews on RCD induced by photodynamic therapy (PDT), a comprehensive summary covering metal-based photosensitizers (PSs) as inducers has not yet presented. In this review, we systematically summarize works PSs that induce different types RCD, including ferroptosis, immunogenic (ICD), pyroptosis. The characteristics mechanisms each explained. At end section, reported commonalities between inducing same is emphasized, future perspectives novel discussed at review. Considering essential roles in therapy, hope review will provide stage for advances inducers.

Language: Английский

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