Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
135(7)
Published: Jan. 17, 2023
Abstract
Since
the
insight
to
fuse
Fenton
chemistry
and
nanomedicine
into
cancer
therapy,
great
signs
of
progress
have
been
made
in
field
chemodynamic
therapy
(CDT).
However,
exact
mechanism
CDT
is
obscured
by
unique
tumor
chemical
environment
inevitable
nanoparticle‐cell
interactions,
thus
impeding
further
development.
In
this
Scientific
Perspective,
significance
clarified,
complex
deconstructed
primitive
biological
research
directions
based
on
kinetics
signaling
pathways
are
discussed
detail.
Moreover,
beneficial
outlooks
presented
enlighten
evolution
next‐generation
CDT.
Hopefully,
Perspective
can
inspire
new
ideas
advances
for
provide
a
reference
breaking
down
interdisciplinary
barriers
nanomedicine.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(7)
Published: Jan. 17, 2023
Abstract
Since
the
insight
to
fuse
Fenton
chemistry
and
nanomedicine
into
cancer
therapy,
great
signs
of
progress
have
been
made
in
field
chemodynamic
therapy
(CDT).
However,
exact
mechanism
CDT
is
obscured
by
unique
tumor
chemical
environment
inevitable
nanoparticle‐cell
interactions,
thus
impeding
further
development.
In
this
Scientific
Perspective,
significance
clarified,
complex
deconstructed
primitive
biological
research
directions
based
on
kinetics
signaling
pathways
are
discussed
detail.
Moreover,
beneficial
outlooks
presented
enlighten
evolution
next‐generation
CDT.
Hopefully,
Perspective
can
inspire
new
ideas
advances
for
provide
a
reference
breaking
down
interdisciplinary
barriers
nanomedicine.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(23), P. 23223 - 23261
Published: Dec. 2, 2023
Stimuli-responsive
polymers
can
respond
to
internal
stimuli,
such
as
reactive
oxygen
species
(ROS),
glutathione
(GSH),
and
pH,
biological
enzymes,
external
lasers
ultrasound,
etc.,
by
changing
their
hydrophobicity/hydrophilicity,
degradability,
ionizability,
thus
have
been
widely
used
in
biomedical
applications.
Due
the
characteristics
of
tumor
microenvironment
(TME),
stimuli-responsive
that
cater
specifically
TME
extensively
prepare
smart
nanovehicles
for
targeted
delivery
therapeutic
diagnostic
agents
tissues.
Compared
conventional
drug
nanosystems,
TME-responsive
nanosystems
many
advantages,
high
sensitivity,
broad
applicability
among
different
tumors,
functional
versatility,
improved
biosafety.
In
recent
years,
a
great
deal
research
has
devoted
engineering
efficient
polymeric
significant
improvement
made
both
cancer
diagnosis
therapy.
this
review,
we
summarize
some
advances
involving
use
polymer
nanocarriers
delivery,
imaging,
therapy,
theranostics.
Various
chemical
stimuli
will
be
described
context
nanosystems.
Accordingly,
groups
responsible
responsiveness
strategies
incorporate
these
into
discussed
detail.
With
on
topic
expending
at
fast
pace,
innovative
concepts,
sequential
cascade
release,
NIR-II
multifunctional
formulations,
emerged
popular
enhanced
performance,
which
also
included
here
with
up-to-date
illustrations.
We
hope
review
offer
valuable
insights
selection
optimization
help
accelerate
future
applications
treatment.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(10)
Published: Feb. 16, 2023
Abstract
The
growing
interest
in
nanomedicine
over
the
last
20
years
has
carved
out
a
research
field
called
“nanocatalytic
therapy,”
where
catalytic
reactions
mediated
by
nanomaterials
are
employed
to
intervene
disease‐critical
biomolecular
processes.
Among
many
kinds
of
catalytic/enzyme‐mimetic
investigated
thus
far,
ceria
nanoparticles
stand
from
others
owing
their
unique
scavenging
properties
against
biologically
noxious
free
radicals,
including
reactive
oxygen
species
(ROS)
and
nitrogen
(RNS),
exerting
enzyme
mimicry
nonenzymatic
activities.
Much
effort
been
made
utilize
as
self‐regenerating
antioxidative
anti‐inflammatory
agents
for
various
diseases,
given
detrimental
effects
ROS
RNS
therein
that
need
alleviation.
In
this
context,
review
is
intended
provide
an
overview
what
makes
merit
attention
disease
therapy.
introductory
part
describes
characteristics
oxygen‐deficient
metal
oxide.
pathophysiological
roles
then
presented,
well
mechanisms
nanoparticles.
Representative
examples
recent
ceria‐nanoparticle‐based
therapeutics
summarized
categorization
into
organ
types,
followed
discussion
on
remaining
challenges
future
directions.
Nano-Micro Letters,
Journal Year:
2023,
Volume and Issue:
15(1)
Published: Feb. 8, 2023
Gene
therapy
provides
a
promising
approach
in
treating
cancers
with
high
efficacy
and
selectivity
few
adverse
effects.
Currently,
the
development
of
functional
vectors
safety
effectiveness
is
intense
focus
for
improving
delivery
nucleic
acid
drugs
gene
therapy.
For
this
purpose,
stimuli-responsive
nanocarriers
displayed
strong
potential
overall
efficiencies
reducing
effects
via
effective
protection,
prolonged
blood
circulation,
specific
tumor
accumulation,
controlled
release
profile
drugs.
Besides,
synergistic
could
be
achieved
when
combined
other
therapeutic
regimens.
This
review
summarizes
recent
advances
various
delivery.
Particularly,
responding
to
endogenous
stimuli
including
pH,
reactive
oxygen
species,
glutathione,
enzyme,
etc.,
exogenous
light,
thermo,
ultrasound,
magnetic
field,
are
introduced.
Finally,
future
challenges
prospects
toward
clinical
translation
well
discussed.
The
major
objective
present
biomedical
cancer
provide
guidance
developing
novel
nanoplatforms
that
clinically
applicable.
Biomaterials Research,
Journal Year:
2022,
Volume and Issue:
26(1)
Published: Sept. 30, 2022
Near-infrared-II
(NIR-II,
1000-1700
nm)
light-triggered
photothermal
therapy
(PTT)
has
been
regarded
as
a
promising
candidate
for
cancer
treatment,
but
PTT
alone
often
fails
to
achieve
satisfactory
curative
outcomes.
Hollow
nanoplatforms
prove
be
attractive
in
the
biomedical
field
owing
merits
including
good
biocompatibility,
intrinsic
physical-chemical
nature
and
unique
hollow
structures,
etc.
On
one
hand,
themselves
can
NIR-II
agents
(PTAs),
cavities
of
which
are
able
carry
diverse
therapeutic
units
realize
multi-modal
therapies.
other
PTAs
capable
decorating
on
surface
combine
with
functions
components
encapsulated
inside
synergistic
treatment.
Notably,
generally
serve
photoacoustic
imaging
(PAI)
contrast
(CAs),
means
such
kind
also
expected
multifunctional
all-in-one
nanotheranostics.
In
this
review,
recent
advances
single-modal
PTT,
dual-modal
PTT/photodynamic
(PDT),
PTT/chemotherapy,
PTT/catalytic
PTT/gas
well
PTT/chemodynamic
(CDT)/chemotherapy,
PTT/chemo/gene
PTT/PDT/CDT/starvation
(ST)/immunotherapy
summarized
first
time.
Before
these,
typical
synthetic
strategies
structures
presented,
lastly,
potential
challenges
perspectives
related
these
novel
paradigms
future
research
clinical
translation
discussed.
Small,
Journal Year:
2023,
Volume and Issue:
19(19)
Published: Feb. 11, 2023
Abstract
Nowadays,
Fenton
chemistry‐based
chemodynamic
therapy
(CDT)
is
an
emerging
approach
to
killing
tumor
cells
by
converting
endogenous
H
2
O
into
cytotoxic
hydroxyl
radicals
(·OH).
However,
the
elimination
of
·OH
intracellular
overexpressed
glutathione
(GSH)
results
in
unsatisfactory
antitumor
efficiency.
In
addition,
single
mode
consuming
GSH
and
undesirable
drug
loading
efficiency
cannot
guarantee
efficient
cancer
effect.
Herein,
a
simple
one‐step
strategy
for
construction
Fe
3+
‐naphthazarin
metal–phenolic
networks
(FNP
MPNs)
with
ultrahigh
capacity,
followed
modification
NH
‐PEG‐NH
,
developed.
The
carrier‐free
FNP
MPNs
can
be
triggered
acid
GSH,
rapidly
release
naphthazarin
which
further
reduced
2+
that
exerts
catalytic
activity
produce
abundant
·OH.
Meanwhile,
Michael
addition
between
lead
depletion
thus
achieve
microenvironment
(TME)‐triggered
enhanced
CDT,
activating
ferroptosis
apoptosis.
as
T
1
‐weighted
contrast
agent
endows
magnetic
resonance
imaging
(MRI)
functionality.
Overall,
this
work
debut
ligands
fabricate
functional
effectively
depleting
disrupting
redox
homeostasis,
enhancing
CDT
effects,
opens
new
perspectives
on
multifunctional
synergistic
therapy.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(34)
Published: June 11, 2024
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
severe
trauma,
surgical
resection,
degenerative
disease,
congenital
malformation
pose
significant
clinical
challenges.
Bone
tissue
engineering
(BTE)
holds
immense
potential
in
treating
these
defects,
without
incurring
prevalent
complications
associated
with
conventional
autologous
or
allogeneic
grafts.
3D
printing
technology
enables
control
over
architectural
structures
at
multiple
length
scales
has
been
extensively
employed
to
process
biomimetic
scaffolds
for
BTE.
In
contrast
inert
grafts,
next-generation
smart
possess
a
remarkable
ability
mimic
the
dynamic
nature
native
extracellular
matrix
(ECM),
thereby
facilitating
regeneration.
Additionally,
they
can
generate
tailored
controllable
therapeutic
effects,
such
as
antibacterial
antitumor
properties,
response
exogenous
and/or
endogenous
stimuli.
This
review
provides
comprehensive
assessment
progress
3D-printed
BTE
applications.
It
begins
an
introduction
physiology,
followed
by
overview
technologies
utilized
scaffolds.
Notable
advances
various
stimuli-responsive
strategies,
efficacy,
applications
are
discussed.
Finally,
highlights
existing
challenges
development
implementation
scaffolds,
well
emerging
this
field.
