Iron Metabolism and Ferroptosis in Epilepsy

Frontiers in Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: Dec. 8, 2020

Epilepsy is a disease characterized by recurrent, episodic, and transient central nervous system (CNS) dysfunction resulting from an excessive synchronous discharge of brain neurons. It diverse etiology, complex pathogenesis, difficult treatment. In addition, most epileptic patients exhibit social cognitive impairment psychological impairment. Iron essential trace element for human growth development also involved in variety redox reactions organisms. However, abnormal iron metabolism associated with several neurological disorders, including hemorrhagic post-stroke epilepsy post-traumatic (PTE). Moreover, ferroptosis considered new form regulation cell death, which attributed to severe lipid peroxidation caused the production reactive oxygen species (ROS) overload found various diseases, epilepsy. Therefore, this review summarizes study on epilepsy, order elucidate correlation between provides novel method treatment, prevention, research control seizures reduce nerve injury after seizure.

Language: Английский

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Nanomedicine potentiates mild photothermal therapy for tumor ablation

Asian Journal of Pharmaceutical Sciences, Journal Year: 2021, Volume and Issue: 16(6), P. 738 - 761

Published: Oct. 16, 2021

The booming photothermal therapy (PTT) has achieved great progress in non-invasive oncotherapy, and paves a novel way for clinical oncotherapy. Of note, mild temperature PTT (mPTT) of 42-45 °C could avoid treatment bottleneck the traditional PTT, including nonspecific injury to normal tissues, vasculature host antitumor immunity. However, cancer cells can resist mPTT via heat shock response autophagy, thus leading insufficient monotherapy ablate tumor. To overcome deficient efficacy caused by thermo-resistance mono mPTT, synergistic therapies towards have been conducted with mPTT. This review summarizes recent advances nanomedicine-potentiated treatment, strategies enhanced single-mode plus therapies. Moreover, challenges prospects translation are discussed.

Language: Английский

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Copper‐Based Nanoscale Coordination Polymers Augmented Tumor Radioimmunotherapy for Immunogenic Cell Death Induction and T‐Cell Infiltration

Small, Journal Year: 2021, Volume and Issue: 17(8)

Published: Feb. 1, 2021

Abstract Insufficient T‐cell infiltration seriously hinders the efficacy of tumor immunotherapy. Induction immunogenic cell death (ICD) is a potentially feasible approach to increase infiltration. Since ionizing radiation can only induce low‐level ICD, this study constructs Cu‐based nanoscale coordination polymers (Cu‐NCPs) with mixed‐valence (Cu + /Cu 2+ ), which simultaneously and independently generation Cu ‐triggered hydroxyl radicals GSH elimination, synergize therapy for potent ICD induction. Markedly, synergetic remarkably enhances dendritic maturation promotes antitumor CD8 infiltration, thereby potentiating development checkpoint blockade immunotherapies against primary metastatic tumors.

Language: Английский

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Passively-targeted mitochondrial tungsten-based nanodots for efficient acute kidney injury treatment

Bioactive Materials, Journal Year: 2022, Volume and Issue: 21, P. 381 - 393

Published: Sept. 14, 2022

Acute kidney injury (AKI) can lead to loss of function and a substantial increase in mortality. The burst reactive oxygen species (ROS) plays key role the pathological progression AKI. Mitochondrial-targeted antioxidant therapy is very promising because mitochondria are main source ROS Antioxidant nanodrugs with actively targeted have achieved encouraging success many oxidative stress-induced diseases. However, most strategies target make size too large pass through glomerular system reach renal tubules, damage site Here, an ultra-small Tungsten-based nanodots (TWNDs) strong scavenging be effective for treatment TWNDs tubular after crossing barrier, enter tubule without resorting complex active targeting strategies. To our knowledge, this first time that negatively charged used passively mitochondrial Through in-depth study therapeutic mechanism, such passive mitochondria-targeted highly protecting by reducing increasing mitophagy. In addition, also reduce infiltration inflammatory cells. This work provides new way AKI, give inspiration major diseases closely related mitochondria, as myocardial infarction cerebral infarction.

Language: Английский

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Oxidative stress-amplified nanomedicine for intensified ferroptosis-apoptosis combined tumor therapy

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 347, P. 104 - 114

Published: May 6, 2022

Language: Английский

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