Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 674, P. 9 - 18
Published: June 21, 2024
Language: Английский
Small, Journal Year: 2024, Volume and Issue: 20(26)
Published: Jan. 14, 2024
Abstract Ferroptosis, a novel form of nonapoptotic cell death, can effectively enhance photodynamic therapy (PDT) performance by disrupting intracellular redox homeostasis and promoting apoptosis. However, the extremely hypoxic tumor microenvironment (TME) together with highly expressed hypoxia‐inducible factor‐1α (HIF‐1α) presents considerable challenge for clinical PDT against osteosarcoma (OS). Hence, an innovative nanoplatform that enhances antitumor inducing ferroptosis alleviating hypoxia is fabricated. Capsaicin (CAP) widely reported to specifically activate transient receptor potential vanilloid 1 (TRPV1) channel, trigger increase in Ca 2+ concentration, which closely linked ferroptosis, participate decreased oxygen consumption inhibiting HIF‐1α cells, potentiating efficiency. Thus, CAP photosensitizer IR780 are coencapsulated into biocompatible human serum albumin (HSA) construct (CI@HSA NPs) synergistic treatment under near‐infrared (NIR) irradiation. Furthermore, underlying signaling pathways combination investigated. CI@HSA NPs achieve real‐time dynamic distribution monitoring exhibit excellent efficacy superior biosafety vivo. Overall, this work highlights promising NIR imaging‐guided “pro‐death” strategy overcome limitations OS hypoxia, providing inspiration support future approaches.
Language: Английский
Citations
18
Biomaterials Advances, Journal Year: 2024, Volume and Issue: 158, P. 213771 - 213771
Published: Jan. 21, 2024
Language: Английский
Citations
16
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.
Language: Английский
Citations
4
Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(12), P. 4472 - 4485
Published: Aug. 19, 2022
Hydrogen sulfide (H2S) is the most recently discovered gasotransmitter molecule that activates multiple intracellular signaling pathways and exerts concentration-dependent antitumor effect by interfering with mitochondrial respiration inhibiting cellular ATP generation. Inspired fact H2S can also serve as a promoter for Ca2+ influx, tumor-specific nanomodulators ([email protected]) have been constructed encapsulating calcium (CaS) indocyanine green (ICG) into methoxy poly (ethylene glycol)-b-poly (lactide-co-glycolide) (PLGA-PEG). [email protected] achieve biodegradability high biocompatibility pH-responsive release. The released effectively suppress catalase (CAT) activity synergize to facilitate abnormal retention in cells, thus leading mitochondria destruction amplification of oxidative stress. Mitochondrial dysfunction further contributes blocking synthesis downregulating heat shock proteins (HSPs) expression, which beneficial overcome endurance tumor cells strengthen ICG-induced photothermal performance. Such H2S-boosted Ca2+-involved therapy exhibits highly effective inhibition almost complete elimination within 14-day treatment, indicating great prospect CaS-based therapeutics.
Language: Английский
Citations
41
Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(4), P. 100829 - 100829
Published: July 1, 2023
Current antitumor monotherapy has many limitations, highlighting the need for novel synergistic anticancer strategies. Ferroptosis is an iron-dependent form of nonapoptotic cell death that plays a pivotal regulatory role in tumorigenesis and treatment. Photodynamic therapy (PDT) causes irreversible chemical damage to target lesions widely used therapy. However, PDT's effectiveness usually hindered by several obstacles, such as hypoxia, excess glutathione (GSH), tumor resistance. improves efficacy PDT increasing oxygen reactive species (ROS) or reducing GSH levels, also enhances ferroptosis induction due ROS effect microenvironment (TME). Strategies based on nanoparticles (NPs) can subtly exploit potential synergy PDT. This review explores recent advances current challenges landscape underlying mechanisms regulating PDT, well nano delivery system-mediated activity. These include polymers, biomimetic materials, metal organic frameworks (MOFs), inorganics, carrier-free NPs. Finally, we highlight future perspectives this emerging paradigm targeted cancer therapies.
Language: Английский
Citations
37
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14614 - 14614
Published: Sept. 27, 2023
Lung adenocarcinoma (LUAD) is the most common lung cancer, which accounts for about 35-40% of all cancer patients. Despite therapeutic advancements in recent years, overall survival time LUAD patients still remains poor, especially KRAS mutant LUAD. Therefore, it necessary to further explore novel targets and drugs improve prognos Ferroptosis, an iron-dependent regulated cell death (RCD) caused by lipid peroxidation, has attracted much attention recently as alternative target apoptosis therapy. Ferroptosis been found be closely related at every stage, including initiation, proliferation, progression. In this review, we will provide a comprehensive overview ferroptosis mechanisms, its regulation LUAD, application targeting
Language: Английский
Citations
32
Biomedical Technology, Journal Year: 2023, Volume and Issue: 3, P. 40 - 51
Published: Jan. 23, 2023
Fenton and like reaction have been well clarified as efficient reactive oxygen species (ROS) sources in tumor, widely developed into a cancer treatment method. Meanwhile, transition metal-based nanomaterials with or characteristics also explored therapeutic agents for the therapy, mainly chemo-dynamic ferroptosis induced therapy. Herein,to summarize recent advances mediated nanoparticles this minireview, we first introduced mechanisms of two methods based on reaction, then well-designed Fenton-like therapies. Finally its challenges perspectives are discussed.
Language: Английский
Citations
26
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 660, P. 637 - 646
Published: Jan. 21, 2024
Language: Английский
Citations
13
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(5), P. 1379 - 1392
Published: Jan. 1, 2024
The constructed ZnS–Ti 3 C 2 /PLLA scaffolds were able to release H S gas disrupt biofilm and further remove bacteria through photothermal. In addition, the Zn 2+ released from composite could promote osteogenic differentiation of BMSCs.
Language: Английский
Citations
12
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149518 - 149518
Published: Feb. 10, 2024
Language: Английский
Citations
11