Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Polymers, Journal Year: 2022, Volume and Issue: 14(15), P. 3023 - 3023

Published: July 26, 2022

Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced solved. Hydrogels have been proposed excellent candidates these they promising properties the mentioned including biocompatibility, biodegradability, great absorption capacity tunable mechanical properties. However, depending on material or manufacturing method, resulting hydrogel may not up to specific task it is designed, thus different approaches enhance performance requirements of application in question. The main purpose this review article was summarize most recent trends technology, going through used polymeric materials popular synthesis methods years, strategies enhancing hydrogels' properties, cross-linking manufacture composite hydrogels. In addition, secondary objective briefly discuss other novel applications hydrogels that past few years drawn a lot attention.

Language: Английский

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Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

International Journal of Oral Science, Journal Year: 2021, Volume and Issue: 13(1)

Published: March 16, 2021

Issues caused by maxillofacial tumours involve not only dealing with but also repairing jaw bone defects. In traditional tumour therapy, the systemic toxicity of chemotherapeutic drugs, invasive surgical resection, intractable recurrence, and metastasis are major threats to patients' lives in clinic. Fortunately, biomaterial-based intervention can improve efficiency treatment decrease possibility recurrence metastasis, suggesting new promising antitumour therapies. addition, tissue defects their negatively affect physiological psychological health patients, investment result a multitude burdens society. Biomaterials options because they have good biocompatibility bioactive properties for stimulation regeneration. More interestingly, an integrated material regimen that combines therapy repair is option. Herein, we summarized biomaterial-mediated treatments analysed biomaterials defect repair. Furthermore, proposed superior design dual-functional simultaneous regeneration provide strategy managing quality life patients future.

Language: Английский

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New Insights of Scaffolds Based on Hydrogels in Tissue Engineering

Polymers, Journal Year: 2022, Volume and Issue: 14(4), P. 799 - 799

Published: Feb. 18, 2022

In recent years, biomaterials development and characterization for new applications in regenerative medicine or controlled release represent one of the biggest challenges. Tissue engineering is most intensively studied domain where hydrogels are considered optimum biomedical field. The delicate nature their low mechanical strength limit exploitation tissue engineering. Hence, developing new, stronger, more stable with increased biocompatibility, essential. However, both natural synthetic polymers possess many limitations. Hydrogels based on offer particularly high biocompatibility biodegradability, immunogenicity, excellent cytocompatibility, variable, controllable solubility. At same time, they have poor properties, production costs, reproducibility. Synthetic come to aid through superior strength, reproducibility, reduced ability regulate composition improve processes such as hydrolysis biodegradation over variable periods. mixtures can lead optimization properties obtain ideal scaffolds. Also, incorporating different nanoparticles hydrogel's stability several biological effects. this regard, essential oils drug molecules facilitate desired effect even produce a synergistic effect. This study's main purpose establish needed develop sustainable polymeric These scaffolds be applied regeneration process without producing other side effects environment.

Language: Английский

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Advances in bioactive glass-containing injectable hydrogel biomaterials for tissue regeneration

Acta Biomaterialia, Journal Year: 2021, Volume and Issue: 136, P. 1 - 36

Published: Sept. 23, 2021

Language: Английский

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Biomaterials / bioinks and extrusion bioprinting

Bioactive Materials, Journal Year: 2023, Volume and Issue: 28, P. 511 - 536

Published: June 27, 2023

Bioinks are formulations of biomaterials and living cells, sometimes with growth factors or other biomolecules, while extrusion bioprinting is an emerging technique to apply deposit these bioinks biomaterial solutions create three-dimensional (3D) constructs architectures mechanical/biological properties that mimic those native human tissue organs. Printed have found wide applications in engineering for repairing treating tissue/organ injuries, as well vitro modelling testing validating newly developed therapeutics vaccines prior their use humans. Successful printing subsequent rely on the formulated bioinks, including rheological, mechanical, biological properties, process. This article critically reviews latest developments bioprinting, focusing bioink synthesis characterization, influence Key issues challenges also discussed along recommendations future research.

Language: Английский

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Supramolecular Peptide Nanofiber Hydrogels for Bone Tissue Engineering: From Multihierarchical Fabrications to Comprehensive Applications

Advanced Science, Journal Year: 2022, Volume and Issue: 9(11)

Published: Feb. 7, 2022

Abstract Bone tissue engineering is becoming an ideal strategy to replace autologous bone grafts for surgical repair, but the multihierarchical complexity of natural still difficult emulate due lack suitable biomaterials. Supramolecular peptide nanofiber hydrogels (SPNHs) are emerging biomaterials because their inherent biocompatibility, satisfied biodegradability, high purity, facile functionalization, and tunable mechanical properties. This review initially focuses on fabrications by SPNHs bony extracellular matrix. Structurally, supramolecular peptides based distinctive building blocks can assemble into hydrogels, which be used as nanomorphology‐mimetic scaffolds engineering. Biochemically, bioactive motifs factors covalently tethered or physically absorbed endow various functions depending physiological pharmacological requirements. Mechanically, four strategies summarized optimize biophysical microenvironment regeneration. Furthermore, comprehensive applications about reviewed. The directly in form injectable composite nanoscaffolds, they construct engineered bioprinting bioreactors. Finally, continuing challenges outlook discussed.

Language: Английский

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Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications

Polymers, Journal Year: 2023, Volume and Issue: 15(5), P. 1160 - 1160

Published: Feb. 25, 2023

Self-assembly is a growth mechanism in nature to apply local interactions forming minimum energy structure. Currently, self-assembled materials are considered for biomedical applications due their pleasant features, including scalability, versatility, simplicity, and inexpensiveness. Self-assembled peptides can be applied design fabricate different structures, such as micelles, hydrogels, vesicles, by diverse physical between specific building blocks. Among them, bioactivity, biocompatibility, biodegradability of peptide hydrogels have introduced them versatile platforms applications, drug delivery, tissue engineering, biosensing, treating diseases. Moreover, capable mimicking the microenvironment natural tissues responding internal external stimuli triggered release. In current review, unique characteristics recent advances design, fabrication, well chemical, physical, biological properties presented. Additionally, developments these biomaterials discussed with particular focus on targeted delivery gene stem cell therapy, cancer therapy immune regulation, bioimaging, regenerative medicine.

Language: Английский

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Bioinspired Intrinsic Versatile Hydrogel Fabricated by Amyloidal Toxin Simulant‐Based Nanofibrous Assemblies for Accelerated Diabetic Wound Healing

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(49)

Published: Sept. 9, 2021

Abstract Persistent microbial infection and decreased neovascularization are common issues associated with diabetic wound treatment. Hydrogel dressings that offer intrinsic antibacterial angiogenesis‐inducing may substantially avoid the use of antibiotics or angiogenic agents. Herein, a versatile hydrogel is fabricated using an amyloid‐derived toxin simulant (Fmoc‐LFKFFK‐NH 2 , FLN) as building blocks, inspired by defense strategy Staphylococcus aureus (S. aureus) . The assemblies function both matrix components functional elements for undergoes quick assembly from random monomers to nanofibrils abundant b ‐sheet driven multiple non‐covalent interactions. developed demonstrates excellent biocompatibility accelerates angiogenesis via hypoxia‐inducible factor 1α (HIF‐1α) vascular endothelial growth A (VEGFA) signaling consequence its amyloidal structure. simulant‐based endow broad‐spectrum activity dominated membrane‐disruption mechanism. In addition, exhibits performance compared commercial Prontosan in accelerating healing mice infected methicillin‐resistant S. (MRSA). This study highlights fabrication single component platform, thereby avoiding drug‐related side effects complicated preparations demonstrating profound potential clinical dressing management microbe‐infected wounds.

Language: Английский

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Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: Nov. 16, 2021

Peptide-based hydrogels have captivated remarkable attention in recent times and serve as an excellent platform for biomedical applications owing to the impressive amalgamation of unique properties such biocompatibility, biodegradability, easily tunable hydrophilicity/hydrophobicity, modular incorporation stimuli sensitivity other functionalities, adjustable mechanical stiffness/rigidity close mimicry biological molecules. Putting all these on same plate offers smart soft materials that can be used tissue engineering, drug delivery, 3D bioprinting, wound healing name a few. A plethora work has been accomplished significant progress realized using peptide-based platforms. However, designing hydrogelators with desired functionalities their self-assembled nanostructures is still highly serendipitous nature thus roadmap providing guidelines toward preparing soft-materials applying them goal pressing need hour. This review aims provide concise outline purpose design principles along potential are discussed help selected reports.

Language: Английский

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Engineering bioactive synthetic polymers for biomedical applications: a review with emphasis on tissue engineering and controlled release

Materials Advances, Journal Year: 2021, Volume and Issue: 2(14), P. 4447 - 4478

Published: Jan. 1, 2021

We review strategies for engineering synthetic polymers from fabrication to chemical functionalization biomedical applications. Particular emphasis is devoted related tissue and controlled release

Language: Английский

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