Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(5), P. 713 - 734
Published: May 3, 2024
Introduction Polymer nanogels are among the most promising nanoplatforms for use in biomedical applications. The substantial interest these drug carriers is to enhance transportation of bioactive substances, reduce side effects, and achieve optimal action on curative sites by targeting delivery triggering release drugs a controlled continuous mode.
Language: Английский
Gels, Journal Year: 2023, Volume and Issue: 9(7), P. 523 - 523
Published: June 27, 2023
Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts water and biological fluids control release based on unique physicochemical properties biocompatibility. Current trends in the development hydrogel systems involve drugs response specific triggers such as pH, temperature, or enzymes targeted reduce potential systemic toxicity. In addition, developing injectable formulations that easily used sustain during this extended time is a growing interest. Another emerging trend synthesis nano other functional substances improving loading efficacy. Following these trends, advanced possessing mechanically improved properties, controlled rates, biocompatibility focus field. More complex multi-drug combination therapies will be developed advancements. polymer-based gaining increasing attention personalized medicine tailored patient, example, combinations, target-specific delivery, improvement disease treatment effectiveness, healthcare cost reduction. Overall, application advancing rapidly, towards more efficient effective future.
Language: Английский
Citations
289
Advanced Science, Journal Year: 2023, Volume and Issue: 11(1)
Published: Nov. 20, 2023
Abstract Deregulated inflammations induced by various factors are one of the most common diseases in people's daily life, while severe inflammation can even lead to death. Thus, efficient treatment has always been hot topic research medicine. In past decades, as a potential biomaterial, stimuli‐responsive hydrogels have focus attention for due their excellent biocompatibility and design flexibility. Recently, thanks rapid development nanotechnology material science, more efforts made develop safer, personal effective therapy some frequent but tough such sepsis, rheumatoid arthritis, osteoarthritis, periodontitis, ulcerative colitis. Herein, from recent studies articles, conventional emerging delivery anti‐inflammatory drugs summarized. And prospects clinical translation future also discussed further detail.
Language: Английский
Citations
49
Gels, Journal Year: 2024, Volume and Issue: 10(4), P. 216 - 216
Published: March 22, 2024
Hydrogels, being hydrophilic polymer networks capable of absorbing and retaining aqueous fluids, hold significant promise in biomedical applications owing to their high water content, permeability, structural similarity the extracellular matrix. Recent chemical advancements have bolstered versatility, facilitating integration molecules guiding cellular activities enabling controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity network imperfections, which adversely affect mechanical properties, diffusion rates, biological activity. In response these challenges, hybrid emerged, aiming enhance strength, drug release efficiency, therapeutic effectiveness. These hydrogels, featuring improved formulations, are tailored for tissue regeneration across both soft hard tissues. The scientific community has increasingly recognized versatile characteristics particularly sector. This comprehensive review delves into recent hydrogel systems, covering diverse types, modification strategies, nano/microstructures. discussion includes innovative fabrication techniques click reactions, 3D printing, photopatterning alongside elucidation mechanisms bioactive molecules. By addressing underscores envisages a promising future various domains field.
Language: Английский
Citations
41
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 509, P. 215790 - 215790
Published: March 20, 2024
Language: Английский
Citations
36
Progress in Materials Science, Journal Year: 2024, Volume and Issue: 145, P. 101293 - 101293
Published: April 5, 2024
Language: Английский
Citations
15
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(31), P. 21401 - 21416
Published: June 26, 2024
Long-acting drug delivery systems are promising platforms to improve patient adherence medication by delivering drugs over sustained periods and removing the need for patients comply with oral regimens. This research paper provides a proof-of-concept development of new optimized in situ forming injectable depot based on tetrabenzylamine-tetraglycine-d-lysine-O-phospho-d-tyrosine peptoid-D-peptide formulation ((NPhe)4GGGGk(AZT)y(p)-OH). The chemical versatility peptoid-peptide motif allows low-molecular-weight be precisely covalently conjugated. After subcutaneous injection, hydrogel forms from solubilized peptoid-peptide-drug response phosphatase enzymes present within skin space. system is able deliver clinically relevant concentrations model drug, antiretroviral zidovudine (AZT), 35 days Sprague–Dawley rats. Oscillatory rheology demonstrated that formation began ∼30 s, an important characteristic reducing initial bursts. Gel continued up ∼90 min. Small-angle neutron scattering data reveal narrow-radius fibers (∼0.78–1.8 nm) closely fit via flexible cylinder elliptical model. inclusion non-native peptoid monomers D-variant amino acids confers protease resistance, enabling enhanced biostability vitro. Drug release proceeds hydrolysis ester linkage under physiological conditions, releasing unmodified form further burst. Subcutaneous administration (NPhe)4GGGGk(AZT)y(p)-OH rats resulted blood plasma 90% maximal inhibitory concentration (IC90) range (30–130 ng mL–1) days.
Language: Английский
Citations
13
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 240 - 240
Published: Feb. 6, 2024
Effective drug delivery is essential for cancer treatment. Drug systems, which can be tailored to targeted transport and integrated tumor therapy, are vital in improving the efficiency of Peptides play a significant role various biological physiological functions offer high design flexibility, excellent biocompatibility, adjustable morphology, biodegradability, making them promising candidates delivery. This paper reviews peptide-mediated focusing on self-assembled peptides peptide–drug conjugates. It discusses mechanisms structural control peptides, varieties roles conjugates, strategies augment peptide stability. The review concludes by addressing challenges future directions.
Language: Английский
Citations
11
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132174 - 132174
Published: May 13, 2024
Language: Английский
Citations
10
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(15), P. 18400 - 18410
Published: April 5, 2024
Drug-resistant bacterial infection and biofilm formation are the key inhibitors of wound healing, new strategies urgently needed to address these issues. In this study, we designed a pH-responsive co-assembled peptide hydrogel inhibit Methicillin-resistant Staphylococcus aureus (MRSA) promote healing. We synthesized cationic short (Nap-FFKKK) with curcumin at pH ∼ 7.8. The loaded was continuously released in weak acid environment (pH 5.5). lysine-rich inhibited MRSA via electrostatic interaction negatively charged cell surface and, thus, provided reinforcing antibacterial effect curcumin. vitro experiments showed that system considerably reduced minimum inhibitory concentration against by 10-fold promoted healing mouse model MRSA-infected wounds. This study provides simple promising strategy treat drug-resistant infections
Language: Английский
Citations
9
Bioengineering, Journal Year: 2023, Volume and Issue: 10(8), P. 910 - 910
Published: Aug. 1, 2023
The intensive development of technologies related to human health in recent years has caused a real revolution. transition from conventional medicine personalized medicine, largely driven by bioprinting, is expected have significant positive impact on patient's quality life. This article aims conduct systematic review bioprinting's potential health-related A literature search was conducted accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. comprehensive undertaken using PubMed, Scopus, Google Scholar, ScienceDirect databases between 2019 2023. We identified some most benefits bioprinting improve life: part production; saving millions lives; reducing rejection risks after transplantation; accelerating process skin tissue regeneration; homocellular model generation; precise fabrication accurate specifications; eliminating need organs donor, thus patient waiting time. In addition, these advances greatly benefit cancer treatment other research, offering medical solutions tailored each individual that could increase chance survival significantly their overall well-being. Although advancements are still research stage, encouraging results scientific studies suggest they verge being integrated into treatment. progress power revolutionize healthcare, promising profound improving life potentially transforming field healthcare.
Language: Английский
Citations
22