ROS responsive nanoparticles loaded with lipid-specific AIEgen for atherosclerosis-targeted diagnosis and bifunctional therapy

Biomaterials, Journal Year: 2022, Volume and Issue: 288, P. 121734 - 121734

Published: Aug. 12, 2022

Language: Английский

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Emerging trends in the nanomedicine applications of functionalized magnetic nanoparticles as novel therapies for acute and chronic diseases

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Aug. 31, 2022

Abstract High-quality point-of-care is critical for timely decision of disease diagnosis and healthcare management. In this regard, biosensors have revolutionized the field rapid testing screening, however, are confounded by several technical challenges including material cost, half-life, stability, site-specific targeting, analytes specificity, detection sensitivity that affect overall diagnostic potential therapeutic profile. Despite their advances in testing, very few classical proven effective commercially viable situations emergency recent COVID-19 pandemic. To overcome these functionalized magnetic nanoparticles (MNPs) emerged as key players advancing biomedical sector with promising applications during ongoing crises. This review focus on understanding developments theranostic (MNPs). Given profound global economic health burden, we discuss impact MNPs acute chronic diseases like small RNA therapeutics, vascular diseases, neurological disorders, cancer, well testing. Lastly, culminate a futuristic perspective scope provide an insight into emerging opportunities whose anticipated to disrupt industry. Graphical

Language: Английский

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Inflammatory endothelium-targeted and cathepsin responsive nanoparticles are effective against atherosclerosis

Theranostics, Journal Year: 2022, Volume and Issue: 12(9), P. 4200 - 4220

Published: Jan. 1, 2022

Rationale: Atherosclerosis is characterized by lipid accumulation, plaque formation, and artery stenosis.The pharmacological treatment a promising therapy for atherosclerosis, but this approach faces major challenges such as targeted drug delivery, controlled release, non-specific clearance.Methods: Based on the finding that cathepsin k (CTSK) enzyme enriched in atherosclerotic lesions, we constructed an integrin αvβ3 CTSK-responsive nanoparticle to control release of rapamycin (RAP) locally.The responsive nanoparticles (T/R NPs) were engineered self-assembly targeting polymer PLGA-PEG-c(RGDfC) CTSK-sensitive PLGA-Pep-PEG.PLGA-Pep-PEG was also modified with pair FRET probe monitor hydrolysis events.Results: Our results indicated RAP@T/R NPs accelerated RAP response CTSK stimulation vitro, which significantly inhibited phagocytosis OxLDL cytokines inflammatory macrophages.Additionally, T/R had prolonged blood retention time increased accumulation early late stage atherosclerosis lesions.RAP@T/R blocked development suppressed systemic local inflammation ApoE -/-mice.Conclusions: hold great promise delivery system safer more efficient atherosclerosis.

Language: Английский

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Assessing the Progression of Early Atherosclerosis Mice Using a Fluorescence Nanosensor for the Simultaneous Detection and Imaging of pH and Phosphorylation

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(3)

Published: Nov. 11, 2022

The inflammatory microenvironment involves changes in pH and protein phosphorylation state is closely related to the occurrence development of atherosclerosis (AS). Herein, we constructed a dual-detection fluorescence nanosensor PCN-NP-HPZ based on post modification MOFs, which realized simultaneous detection imaging through pH-sensitive group piperazine ZrIV node MOFs. sensors were used monitor blood phosphate levels at different time stages during atherosclerotic plaque formation. Two-photon was also performed vascular endothelium. Blood tests combined with two-photon images indicated that early stage AS, tissue lower than normal mice, while higher mice. present study provides new analysis method for assessment disease.

Language: Английский

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Targeting Theranostics of Atherosclerosis by Dual‐Responsive Nanoplatform via Photoacoustic Imaging and Three‐In‐One Integrated Lipid Management

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(5)

Published: Nov. 17, 2022

Atherosclerosis, as a life-threatening cardiovascular disease with chronic inflammation and abnormal lipid enrichment, is often difficult to treat timely due the lack of obvious symptoms. In this work, theranostic nanoplatform constructed for noninvasive in vivo diagnosis, plaque-formation inhibition, lesion reversal atherosclerosis. A three-in-one therapeutic complex packaged along polymeric photoacoustic probe into nanoparticles named PLCDP@PMH, which indicates an atherosclerosis-targeting accumulation reactive oxygen species (ROS)/matrix metalloproteinase (MMP) dual-responsive degradation. The suggests lesion-specific imaging on atherosclerotic mice accurate distinct recognition plaques. At same time, performs integrated management through inhibition macrophages M1-polarization, liver X receptor (LXR)-mediated up-regulation ATP-binding cassette transporter A1/G1 (ABCA1/G1) cyclodextrin-assisted dissolution, lead reduced uptake, enhanced efflux, actuated removal. evaluations reveal that PLCDP@PMH can suppress progression further reverse formed plaques under diet without high fat. Hence, provides candidate theranostics early-stage atherosclerosis delivers impressive potential lesions.

Language: Английский

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Role of PET/CT in diagnosing and monitoring disease activity in rheumatoid arthritis: a review

Annals of Nuclear Medicine, Journal Year: 2024, Volume and Issue: 38(3), P. 165 - 175

Published: Jan. 26, 2024

Abstract Rheumatoid Arthritis (RA) is a systemic inflammatory disorder that commonly presents with polyarthritis but can have multisystemic involvement and complications, leading to increased morbidity mortality. The diagnosis of RA continues be challenging due its varied clinical presentations. In this review article, we aim determine the potential PET/CT assist in evaluate therapeutic response treatment, predict remission. has increasingly been used last decade diagnose, monitor treatment response, remissions, diagnose subclinical complications RA. PET imaging [ 18 F]-fluorodeoxyglucose ([ F]-FDG) most applied radiotracer RA, other tracers are also being studied. F]-FDG, F]-NaF, might lead early identification timely evidence-based management, decreasing Although evolving as promising tool for evaluating managing more evidence required before incorporating standard management

Language: Английский

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Targeted Imaging in Atherosclerosis

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(36), P. 12263 - 12273

Published: Aug. 30, 2022

Atherosclerosis is a chronic inflammatory disease involved in plaque rupture, stroke, thrombosis, and heart attack (myocardial infarction), which leading cause of sudden cardiovascular events. In the past decades, various imaging strategies have been designed employed for diagnosis atherosclerosis. Targeted can accurately distinguish pathological tissues from normal reliably reveal biological information occurrence development By taking advantage versatile techniques, rationally probes targeting biomarkers overexpressed microenvironments activated cells by modifying specific ligands accumulated lesion regions attracted increasing attention. This Perspective elucidates comprehensively targeted strategies, current challenges, future directions precise identification atherosclerosis, beneficial to better understand physiological progression exploit novel strategies.

Language: Английский

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Nanomaterials Responsive to Endogenous Biomarkers for Cardiovascular Disease Theranostics

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(26)

Published: March 31, 2023

Abstract Cardiovascular disease (CVD) is the number one cause of death worldwide, which propels development advanced technologies for CVD diagnosis and treatment. Biomarker‐responsive nanomaterials are appealing therapeutic platforms that provide new horizons theranostics. In this review, recent advances in with endogenous biomarkers as stimuli or targets theranostics presented. First, categories involved comprehensively itemized based on pathological mechanisms including pH, reactive oxygen species, lipids, enzymes, macrophage receptors, subendothelium components, platelet inflammation, osteopontin. The role these bridge‐building between then Next, biomedical applications responsive to treatment elaborated. Finally, challenges future research directions biomarker‐responsive also discussed. This review will scientific guidance facilitate clinical nanomaterials.

Language: Английский

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Trans-corneal drug delivery strategies in the treatment of ocular diseases

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 198, P. 114868 - 114868

Published: May 12, 2023

Language: Английский

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Resveratrol and beyond: The Effect of Natural Polyphenols on the Cardiovascular System: A Narrative Review

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 2888 - 2888

Published: Oct. 25, 2023

Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality worldwide. Unhealthy dietary habits have clearly been shown to contribute development CVDs. Beyond primary nutrients, a healthy diet is also rich in plant-derived compounds. Natural polyphenols, found fruits, vegetables, red wine, clear role improving cardiovascular health. In this review, we strive summarize results relevant pre-clinical clinical trials that focused on some most important natural such as resveratrol flavonoids. addition, aim identify their common sources, biosynthesis, describe mechanism action including regulatory effect signal transduction pathways. Finally, provide scientific evidence regarding benefits moderate, long-term wine consumption.

Language: Английский

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