Pharmaceutics,
Journal Year:
2021,
Volume and Issue:
13(8), P. 1114 - 1114
Published: July 21, 2021
For
the
last
40
years,
praziquantel
has
been
standard
treatment
for
schistosomiasis,
a
neglected
parasitic
disease
affecting
more
than
250
million
people
worldwide.
However,
there
is
no
suitable
paediatric
formulation
on
market,
leading
to
off-label
use
and
splitting
of
commercial
tablets
adults.
In
this
study,
we
recently
available
technology,
direct
powder
extrusion
(DPE)
three-dimensional
printing
(3DP),
prepare
Printlets™
(3D
printed
tablets)
amorphous
solid
dispersions
with
Kollidon®
VA
64
surfactants
(Span™
20
or
Kolliphor®
SLS).
Printlets
were
successfully
from
both
pellets
powders
obtained
extrudates
by
hot
melt
(HME).
vitro
dissolution
studies
showed
greater
four-fold
increase
in
release,
due
formation
dispersions.
palatability
data
indicated
that
printlets
range
tolerability,
highlighting
taste
masking
capabilities
technology
without
need
additional
excipients.
This
work
demonstrated
possibility
3D
using
forms
HME,
avoiding
filaments
fused
deposition
modelling
3DP.
Moreover,
main
hurdles
praziquantel,
such
as
low
drug
solubility,
inadequate
taste,
high
variable
dose
requirements,
can
be
overcome
technology.
Discover Artificial Intelligence,
Journal Year:
2022,
Volume and Issue:
2(1)
Published: March 7, 2022
Abstract
The
study
of
artificial
intelligence
(AI)
has
been
a
continuous
endeavor
scientists
and
engineers
for
over
65
years.
simple
contention
is
that
human-created
machines
can
do
more
than
just
labor-intensive
work;
they
develop
human-like
intelligence.
Being
aware
or
not,
AI
penetrated
into
our
daily
lives,
playing
novel
roles
in
industry,
healthcare,
transportation,
education,
many
areas
are
close
to
the
general
public.
believed
be
one
major
drives
change
socio-economical
lives.
In
another
aspect,
contributes
advancement
state-of-the-art
technologies
fields
study,
as
helpful
tools
groundbreaking
research.
However,
prosperity
we
witness
today
was
not
established
smoothly.
During
past
decades,
struggled
through
historical
stages
with
several
winters.
Therefore,
at
this
juncture,
enlighten
future
development,
it
time
discuss
past,
present,
have
an
outlook
on
AI.
article,
will
from
perspective
how
challenges
were
faced
path
revolution
both
systems.
Especially,
addition
technical
development
short
mid-term,
thoughts
insights
also
presented
regarding
symbiotic
relationship
humans
long
run.
Journal of Controlled Release,
Journal Year:
2022,
Volume and Issue:
353, P. 1107 - 1126
Published: Dec. 25, 2022
Colonic
drug
delivery
can
facilitate
access
to
unique
therapeutic
targets
and
has
the
potential
enhance
bioavailability
whilst
reducing
off-target
effects.
Delivering
drugs
colon
requires
considered
formulation
development,
as
both
oral
rectal
dosage
forms
encounter
challenges
if
colon's
distinct
physiological
environment
is
not
appreciated.
As
opportunities
surrounding
colonic
multiply,
success
of
novel
pharmaceuticals
lies
in
their
design.
This
review
provides
a
modern
insight
into
key
parameters
determining
effective
design
development
colon-targeted
medicines.
Influential
features
governing
release,
dissolution,
stability,
absorption
are
first
discussed,
followed
by
an
overview
most
reliable
strategies.
Finally,
appropriate
vitro,
vivo,
silico
preclinical
investigations
presented,
with
goal
inspiring
strategic
new
therapeutics.
International Journal of Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
631, P. 122480 - 122480
Published: Dec. 9, 2022
Three-dimensional
(3D)
printing
is
an
emerging
technology
with
great
potential
in
pharmaceutical
applications,
providing
innovative
solutions
for
both
patients
and
industry.
This
offers
precise
construction
of
the
structure
dosage
forms
can
benefit
drug
product
design
by
versatile
release
modes
to
meet
clinical
needs
facilitating
patient-centric
treatment,
such
as
personalized
dosing,
accommodate
treatment
specific
disease
states
or
patient
populations.
Utilization
3D
also
facilitates
digital
development
manufacturing.
Development
at
early
stages
commercial
scale
manufacturing
has
substantially
advanced
recent
years.
In
this
review,
we
discuss
how
accelerates
early-stage
development,
including
pre-clinical
research
phase
human
studies,
late-stage
well
patients.
The
advantages,
current
status,
challenges
employing
large
dosing
are
introduced
respectively.
considerations
efforts
regulatory
agencies
address
discussed.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(1), P. 145 - 145
Published: Jan. 7, 2022
3D
printing,
or
additive
manufacturing,
has
gained
considerable
interest
due
to
its
versatility
regarding
design
as
well
in
the
large
choice
of
materials.
It
is
a
powerful
tool
field
personalized
pharmaceutical
treatment,
particularly
crucial
for
pediatric
and
geriatric
patients.
Polysaccharides
are
abundant
inexpensive
natural
polymers,
that
already
widely
used
food
industry
excipients
cosmetic
formulations.
Due
their
intrinsic
properties,
such
biocompatibility,
biodegradability,
non-immunogenicity,
etc.,
polysaccharides
largely
investigated
matrices
drug
delivery.
Although
an
increasing
number
interesting
reviews
on
manufacturing
delivery
being
published,
there
gap
concerning
printing
polysaccharides.
In
this
article,
we
will
review
recent
advances
focused
applications.
Among
family
polysaccharides,
present
focus
cellulose
derivatives,
chitosan
sodium
alginate,
printed
by
fused
deposition
modeling
extrusion-based
printing.
