Clotrimazole Mucoadhesive Films with Extended-Release Properties for Vaginal Candidiasis-A Hot-Melt Extrusion Application DOI
Kirti V. Sawant, Rasha M. Elkanayati, Ahmed Almotairy

et al.

Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Revolutionizing manufacturing: A comprehensive overview of additive manufacturing processes, materials, developments, and challenges DOI
Kumar Kanishka, Bappa Acherjee

Journal of Manufacturing Processes, Journal Year: 2023, Volume and Issue: 107, P. 574 - 619

Published: Nov. 8, 2023

Language: Английский

Citations

123

4D Printing in Biomedical Engineering: Advancements, Challenges, and Future Directions DOI Creative Commons
Maziar Ramezani, Zaidi Mohd Ripin

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(7), P. 347 - 347

Published: June 29, 2023

4D printing has emerged as a transformative technology in the field of biomedical engineering, offering potential for dynamic, stimuli-responsive structures with applications tissue drug delivery, medical devices, and diagnostics. This review paper provides comprehensive analysis advancements, challenges, future directions engineering. We discuss development smart materials, including polymers, shape-memory bio-inks, well various fabrication techniques employed, such direct-write assembly, stereolithography, multi-material jetting. Despite promising advances, several challenges persist, material limitations related to biocompatibility, mechanical properties, degradation rates; complexities arising from integration multiple resolution accuracy, scalability; regulatory ethical considerations surrounding safety efficacy. As we explore printing, emphasise need innovations, emerging personalised medicine, nanomedicine, bioelectronic devices. Interdisciplinary research collaboration between science, biology, agencies, industry are essential overcoming realising full engineering landscape.

Language: Английский

Citations

113

Biomaterials as Implants in the Orthopedic Field for Regenerative Medicine: Metal versus Synthetic Polymers DOI Open Access

Faisal Dakhelallah Al-Shalawi,

Azmah Hanim Mohamed Ariff, Dong Won Jung

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(12), P. 2601 - 2601

Published: June 7, 2023

Patients suffering bone fractures in different parts of the body require implants that will enable similar function to natural they are replacing. Joint diseases (rheumatoid arthritis and osteoarthritis) also surgical intervention with such as hip knee joint replacement. Biomaterial utilized fix or replace body. For majority these implant cases, either metal polymer biomaterials chosen order have a functional capacity original material. The employed most often for fracture metals stainless steel titanium, polymers polyethene polyetheretherketone (PEEK). This review compared metallic synthetic can be secure load-bearing due their ability withstand mechanical stresses strains body, focus on classification, properties, application.

Language: Английский

Citations

100

3D printing of magneto-active smart materials for advanced actuators and soft robotics applications DOI Creative Commons
Muhammad Yasir Khalid, Zia Ullah Arif, Ali Tariq

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 205, P. 112718 - 112718

Published: Jan. 2, 2024

In the contemporary era, novel manufacturing technologies like additive (AM) have revolutionized different engineering sectors including biomedical, aerospace, electronics, etc. Four-dimensional (4D) printing aka AM of smart materials is gaining popularity among scientific community, which has excellent ability to make soft structures such as robots, actuators, and grippers. These are developed by applying various stimuli pH, temperature, magnetic field, many combinations onto materials. Stimuli in 3D permit shape-morphing behaviors bending, twisting, folding, swelling, rolling, shrinking, origami, or locomotion. A wide variety can be fabricated through incorporation hard particles into resulting magneto-active (MASMs). With this integration, magneto-thermal coupling actuation allows diverse magneto-deformations, facilitating development personalized devices that capable enhanced deformation. review, guidelines provided on for MASMs polymers (MAPs), composites, hydrogels (MAHs) booming flexible wearable biomimetic devices. Moreover, 3D-printed robotics an outstanding capacity adapt complicated situations advanced actuating applications. Finally, some current challenges emerging areas exciting technology been proposed. Lastly, it anticipated technological advancements developing intelligent will a significant impact design real-world

Language: Английский

Citations

88

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers DOI Creative Commons
Ali Tariq, Zia Ullah Arif, Muhammad Yasir Khalid

et al.

Advanced Engineering Materials, Journal Year: 2023, Volume and Issue: 25(21)

Published: Aug. 29, 2023

Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, robots, wearable devices, sensors, self‐expanding structures, and biomedical thanks to their ability change shapes functional properties in response external stimuli including light, humidity, heat, pH, electric field, solvent, magnetic field or combinations two more these stimuli. In recent years, additive manufacturing (AM) aka 3D printing technology SRPs, also known as 4D printing, has gained phenomenal attention different engineering fields, its unique develop complex, personalized, innovative undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, other complex morphological transformations. Herein, an effort made provide insightful information about the AM techniques, type applications including, but not limited tissue engineering, bionics, construction, smart textiles. This article incorporates current challenges prospects, hoping basis utilization this fields. It is expected that amalgamation with SRPs would unparalleled advantages arenas.

Language: Английский

Citations

87

3D/4D printing of cellulose nanocrystals-based biomaterials: Additives for sustainable applications DOI Creative Commons
Muhammad Yasir Khalid, Zia Ullah Arif,

Reza Noroozi

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 251, P. 126287 - 126287

Published: Aug. 11, 2023

Cellulose nanocrystals (CNCs) have gained significant attraction from both industrial and academic sectors, thanks to their biodegradability, non-toxicity, renewability with remarkable mechanical characteristics. Desirable characteristics of CNCs include high stiffness, strength, excellent flexibility, large surface-to-volume ratio. Additionally, the properties can be tailored through chemical modifications for high-end applications including tissue engineering, actuating, biomedical. Modern manufacturing methods 3D/4D printing are highly advantageous developing sophisticated intricate geometries. This review highlights major developments additive manufactured CNCs, which promote sustainable solutions across a wide range applications. this contribution also presents current challenges future research directions CNC-based composites developed techniques myriad engineering sectors wound healing, wearable electronics, robotics, anti-counterfeiting Overall, will greatly help scientists chemistry, materials, biomedicine, other disciplines comprehend underlying principles, properties, additively structures.

Language: Английский

Citations

77

3D printing of stimuli-responsive hydrogel materials: Literature review and emerging applications DOI Creative Commons
Zia Ullah Arif, Muhammad Yasir Khalid, Ali Tariq

et al.

Giant, Journal Year: 2023, Volume and Issue: 17, P. 100209 - 100209

Published: Nov. 15, 2023

Additive manufacturing (AM) aka three-dimensional (3D) printing has been a well-established and unparalleled technology, which is expanding the boundaries of materials science exhibiting an enormous potential to fabricate intricate geometries for healthcare, electronics, construction sectors. In contemporary era, combination AM technology stimuli-responsive hydrogels (SRHs) helps create dynamic functional structures with extreme accuracy, are capable changing their shape, functional, or mechanical properties in response environmental cues such as humidity, heat, light, pH, magnetic field, electric etc. 3D SRHs permits creation on-demand dynamically controllable shapes excellent control over various self-repair, self-assembly, multi-functionality, These accelerate researchers think unthinkable applications. Additively manufactured objects have shown applications like tissue engineering, drug delivery, soft robots, sensors, other biomedical devices. The current review provides recent progress SRHs, more focus on techniques, stimuli mechanisms, shape morphing behaviors, Finally, trends future roadmap additively smart different also presented, will be helpful research. This holds great promise providing fundamental knowledge about diverse

Language: Английский

Citations

73

Polymer Composites in 3D/4D Printing: Materials, Advances, and Prospects DOI Creative Commons
Ayyaz Mahmood,

Fouzia Perveen,

Shenggui Chen

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(2), P. 319 - 319

Published: Jan. 9, 2024

Additive manufacturing (AM), commonly referred to as 3D printing, has revolutionized the landscape by enabling intricate layer-by-layer construction of three-dimensional objects. In contrast traditional methods relying on molds and tools, AM provides flexibility fabricate diverse components directly from digital models without need for physical alterations machinery. Four-dimensional printing is a revolutionary extension that introduces dimension time, dynamic transformations in printed structures over predetermined periods. This comprehensive review focuses polymeric materials exploring their versatile processing capabilities, environmental adaptability, applications across thermoplastics, thermosetting materials, elastomers, polymer composites, shape memory polymers (SMPs), including liquid crystal elastomer (LCE), self-healing 4D printing. also examines recent advancements microvascular encapsulation mechanisms, explores potential supramolecular polymers, highlights latest progress hybrid using polymer-metal polymer-ceramic composites. Finally, this paper offers insights into challenges faced additive composites suggests avenues future research rapidly evolving field.

Language: Английский

Citations

25

Shape-memory and self-healing properties of sustainable cellulosic nanofibers-based hybrid materials for novel applications DOI Creative Commons
Muhammad Yasir Khalid, Zia Ullah Arif, Ans Al Rashid

et al.

Giant, Journal Year: 2024, Volume and Issue: 19, P. 100299 - 100299

Published: June 5, 2024

In the era of smart and sustainable technology driven by naturally occurring materials, various nanocellulose-based materials play a crucial role. Shape memory behaviour self-healing capabilities nanocelluloses are emerging as focal points in numerous research domains. Nanocellulose its derivatives such cellulose nanocrystals (CNC) nanofibers (CNF), currently limelight due to their excellent shape-memory properties, making them suitable for multifunctional devices. this regard, CNF, cutting-edge material, has spurred researchers explore potential developing contemporary personalized health Therefore, timely comprehensive review is essential gain deep insights into effectiveness CNF Herein, we first provide succinct introduction all nanocellulose materials. This also depicts recent advancements breakthroughs large effective synthesis CNF-based hybrid Next, focusing on performance, sheds new light advanced applications Finally, perspectives current challenges opportunities field summarized future an in-depth understanding "CNF-based materials."

Language: Английский

Citations

18

Rheology in Product Development: An Insight into 3D Printing of Hydrogels and Aerogels DOI Creative Commons
Raquel V. Barrulas, Marta C. Corvo

Gels, Journal Year: 2023, Volume and Issue: 9(12), P. 986 - 986

Published: Dec. 17, 2023

Rheological characterisation plays a crucial role in developing and optimising advanced materials the form of hydrogels aerogels, especially if 3D printing technologies are involved. Applications ranging from tissue engineering to environmental remediation require fine-tuning such properties. Nonetheless, their complex rheological behaviour presents unique challenges additive manufacturing. This review outlines vital parameters that influence printability hydrogel aerogel inks, emphasising importance viscosity, yield stress, viscoelasticity. Furthermore, article discusses latest developments modifiers techniques enable precise control over material deposition resolution printing. By understanding manipulating properties these materials, researchers can explore new possibilities for applications as biomedicine or nanotechnology. An optimal ink requires strong shear-thinning smooth extrusion, forming continuous filaments. Favourable thixotropic aid viscosity recovery post-printing, adequate stress G′ structural integrity, preventing deformation collapse printed objects, ensuring high-fidelity preservation shapes. insight into rheology provides tools future design manufacturing rapidly evolving field aerogels.

Language: Английский

Citations

30