Molecular Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
19(7), P. 1927 - 1951
Published: May 2, 2022
Glioma
is
the
most
common
and
aggressive
primary
intracranial
tumor
within
central
nervous
system.
The
blood–brain
barrier
(BBB)
has
been
a
great
hurdle
for
an
effective
glioma
treatment.
To
effectively
treat
glioma,
various
strategies
have
applied
to
deliver
drugs
brain
by
crossing
BBB.
Nanocarrier-mediated
drug
delivery
emerging
as
noninvasive
system
showing
potential
in
therapy.
In
this
review,
we
will
provide
comprehensive
overview
on
nanocarrier-mediated
related
Following
initial
of
BBB
blood–brain-tumor
(BBTB)
structure
characteristics,
(liposomes,
micelles,
inorganic
systems,
polymeric
nanoparticles,
nanogel
system,
biomimetic
exosomes)
are
discussed.
Finally,
nanotherapeutic
techniques
(imaging-mediated
chemotherapy,
photothermal
therapy,
photodynamic
gene
immunotherapy,
ferroptosis
sonodynamic
chemodynamic
combination
therapy)
treating
summarized.
addition,
review
provides
some
perspectives
clinical
applications
nanomedicines.
Medicinal Research Reviews,
Journal Year:
2023,
Volume and Issue:
43(6), P. 2115 - 2176
Published: May 11, 2023
Abstract
Breast
cancer
is
the
most
malignant
tumor
in
women,
and
there
no
absolute
cure
for
it.
Although
treatment
modalities
including
surgery,
chemotherapy,
radiotherapy
are
utilized
breast
cancer,
it
still
a
life‐threatening
disease
humans.
Nanomedicine
has
provided
new
opportunity
treatment,
which
focus
of
current
study.
The
nanocarriers
deliver
chemotherapeutic
agents
natural
products,
both
increase
cytotoxicity
against
cells
prevent
development
drug
resistance.
efficacy
gene
therapy
boosted
by
nanoparticles
delivery
CRISPR/Cas9,
Noncoding
RNAs,
RNAi,
promoting
their
potential
expression
regulation.
codelivery
can
exert
synergistic
impact
on
tumors
enhance
cellular
uptake
via
endocytosis.
Nanostructures
able
to
induce
photothermal
photodynamic
ablation
cell
death
induction.
provide
microenvironment
remodeling
repolarization
macrophages
antitumor
immunity.
stimuli‐responsive
nanocarriers,
pH‐,
redox‐,
light‐sensitive,
mediate
targeted
suppression
tumors.
Besides,
diagnosis
detect
biomarkers.
Various
kinds
have
been
employed
therapy,
carbon‐,
lipid‐,
polymeric‐
metal‐based
nanostructures,
different
terms
biocompatibility
efficiency.
Biomaterials Research,
Journal Year:
2022,
Volume and Issue:
26(1)
Published: Sept. 30, 2022
Near-infrared-II
(NIR-II,
1000-1700
nm)
light-triggered
photothermal
therapy
(PTT)
has
been
regarded
as
a
promising
candidate
for
cancer
treatment,
but
PTT
alone
often
fails
to
achieve
satisfactory
curative
outcomes.
Hollow
nanoplatforms
prove
be
attractive
in
the
biomedical
field
owing
merits
including
good
biocompatibility,
intrinsic
physical-chemical
nature
and
unique
hollow
structures,
etc.
On
one
hand,
themselves
can
NIR-II
agents
(PTAs),
cavities
of
which
are
able
carry
diverse
therapeutic
units
realize
multi-modal
therapies.
other
PTAs
capable
decorating
on
surface
combine
with
functions
components
encapsulated
inside
synergistic
treatment.
Notably,
generally
serve
photoacoustic
imaging
(PAI)
contrast
(CAs),
means
such
kind
also
expected
multifunctional
all-in-one
nanotheranostics.
In
this
review,
recent
advances
single-modal
PTT,
dual-modal
PTT/photodynamic
(PDT),
PTT/chemotherapy,
PTT/catalytic
PTT/gas
well
PTT/chemodynamic
(CDT)/chemotherapy,
PTT/chemo/gene
PTT/PDT/CDT/starvation
(ST)/immunotherapy
summarized
first
time.
Before
these,
typical
synthetic
strategies
structures
presented,
lastly,
potential
challenges
perspectives
related
these
novel
paradigms
future
research
clinical
translation
discussed.
Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(3), P. 399 - 399
Published: Jan. 26, 2022
Nanomedicine
involves
the
use
of
nanotechnology
for
clinical
applications
and
holds
promise
to
improve
treatments.
Recent
developments
offer
new
hope
cancer
detection,
prevention
treatment;
however,
being
a
heterogenous
disorder,
calls
more
targeted
treatment
approach.
Personalized
Medicine
(PM)
aims
revolutionize
therapy
by
matching
most
effective
individual
patients.
Nanotheranostics
comprise
combination
diagnostic
imaging
incorporated
in
nanosystem
are
developed
fulfill
PM
helping
selection
treatments,
objective
monitoring
response
planning
follow-up
therapy.
Although
well-established
techniques,
such
as
Magnetic
Resonance
Imaging
(MRI),
Computed
Tomography
(CT),
Positron
Emission
(PET)
Single-Photon
(SPECT),
primarily
used
development
theranostics,
Optical
(OI)
offers
some
advantages,
high
sensitivity,
spatial
temporal
resolution
less
invasiveness.
Additionally,
it
allows
multiplexing,
using
multi-color
DNA
barcoding,
which
further
aids
personalized
advances
have
also
given
rise
techniques
permitting
better
penetration,
opening
doors
OI-guided
nanotheranostics.
In
this
review,
we
describe
detail
these
recent
that
may
be
design
develop
efficient
specific
nanotheranostics
drug
delivery.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(4), P. 1367 - 1367
Published: Feb. 17, 2022
The
green
synthesis
of
metal
oxide
nanoparticles
is
presented
as
an
excellent
sustainable
alternative
for
achieving
nanostructures,
with
potential
applications.
This
research
provides
important
information
regarding
the
influence
type
solvent
used
in
extracting
organic
reducing
agents
from
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(51)
Published: May 5, 2023
Abstract
Recently,
2D
transition
metal
carbide,
nitride,
and
carbonitrides
(MXenes)
materials
stand
out
in
the
field
of
tumor
therapy,
particularly
construction
functional
platforms
for
optimal
antitumor
therapy
due
to
their
high
specific
surface
area,
tunable
performance,
strong
absorption
near‐infrared
light
as
well
preferable
plasmon
resonance
effect.
In
this
review,
progress
MXene‐mediated
is
summarized
after
appropriate
modifications
or
integration
procedures.
The
enhanced
treatments
directly
performed
by
MXenes,
significant
improving
effect
MXenes
on
different
therapies,
imaging‐guided
strategies
are
discussed
detail.
Moreover,
existing
challenges
future
development
directions
presented.
Accounts of Chemical Research,
Journal Year:
2023,
Volume and Issue:
56(4), P. 425 - 439
Published: Feb. 6, 2023
ConspectusSurface-modified
lanthanide
nanoparticles
have
been
widely
developed
as
an
emerging
class
of
therapeutics
for
cancer
treatment
because
they
exhibit
several
unique
properties.
First,
a
variety
diagnostic
capabilities
suitable
various
image-guided
therapies.
Second,
large
number
therapeutic
molecules
can
be
accommodated
on
the
surface
nanoparticles,
which
simultaneously
achieve
combined
therapy.
Third,
multivalent
targeting
ligands
easily
modified
to
high
affinity
and
specificity
target
cells.
Last
but
not
least,
engineered
spatially
temporally
controlled
tumor
therapy,
is
critical
developing
precise
personalized
Surface-modified
lanthanide-doped
are
used
in
phototherapy.
This
due
their
optical
properties,
including
anti-Stokes
shifts,
long-lasting
luminescence,
photostability,
capacity
near-infrared
or
X-ray
excitation.
Upon
irradiation,
these
emit
ultraviolet
visible
light,
activates
photosensitizers
photothermal
agents
destroy
Surface
modification
with
special
that
respond
microenvironment
changes,
such
acidic
pH,
hypoxia,
redox
reactions,
turn
into
smart
nanoplatform
light-guided
chemotherapy
gene
Surface-engineered
include
antigens
elicit
tumor-specific
immune
responses,
well
activators
boost
immunity,
allowing
distant
metastatic
tumors
eradicated.
The
design
chemistry
crucial
improving
therapy
without
causing
side
effects.
In
this
Account,
we
classify
surface-modified
four
main
domains:
phototherapy,
radiotherapy,
chemotherapy,
biotherapy.
We
begin
by
introducing
fundamental
bioapplications
then
discuss
recent
developments
phototherapy
(photodynamic
therapy),
biotherapy
(gene
immunotherapy).
also
assess
viability
strategies
eliminating
cells
through
innovative
pathways.
Finally,
future
opportunities
challenges
development
more
efficient
nanoprobes
discussed.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
19, P. 100556 - 100556
Published: Jan. 20, 2023
Biomaterials
and
pertaining
formulations
have
been
very
successful
in
various
diagnostic
therapeutic
applications
because
of
its
ability
to
overcome
pharmacological
limitations.
Some
them
gained
significant
focus
the
recent
decade
for
their
theranostic
properties.
Exosomes
can
be
grouped
as
biomaterials,
since
they
consist
biological
micro/macromolecules
possess
all
properties
a
stable
biomaterial
with
size
nano
range.
Significant
research
has
gone
into
isolation
exploitation
exosomes
potential
agent.
However,
limitations
terms
yield,
efficacy,
target
specificity
are
continuously
being
addressed.
On
other
hand,
several
nano/microformulations
responsive
physical
or
chemical
alterations
were
successfully
stimulated
by
tweaking
characteristics
surrounding
environment
in.
termed
photodynamic,
sonodynamic
thermodynamic
systems.
In
this
regard,
ultrasound
acoustic
systems
extensively
studied
towards
altering
which
applied
on.
review,
we
detailed
about
separately,
consisting
conventional
applications,
drawbacks,
developments
addressing
challenges.
The
information
categorized
sections
that
provide
complete
overview
strategies
diseases.
Then
ultrasound-based
disease
diagnosis
therapy
elaborated,
special
interest
use
enhancing
efficacy
nanomedicines
nanodrug
delivery
systems,
Finally,
discussed
exosomes,
could
future
theranostics.
Small,
Journal Year:
2024,
Volume and Issue:
20(44)
Published: July 6, 2024
Abstract
Sonodynamic
therapy
(SDT),
featuring
noninvasive,
deeper
penetration,
low
cost,
and
repeatability,
is
a
promising
approach
for
deep‐seated
tumors.
However,
the
general
or
only
utilization
of
SDT
shows
efficiency
unsatisfactory
treatment
outcomes
due
to
complicated
tumor
microenvironment
(TME)
process.
To
circumvent
issues,
three
feasible
approaches
enhancing
SDT‐based
therapeutic
effects,
including
sonosensitizer
optimization,
strategies
conquering
hypoxia
TME,
combinational
are
summarized,
with
particular
focus
on
combination
other
modalities,
chemodynamic
therapy,
photodynamic
photothermal
chemotherapy,
starvation
gas
immunotherapy.
In
end,
current
challenges
in
tumors
discussed
enhanced
effects
provided.
It
envisioned
that
this
review
will
provide
new
insight
into
strategic
design
high‐efficiency
sonosensitizer‐derived
nanotheranostics,
thereby
augmenting
accelerating
potential
clinical
transformation.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 3, 2024
Abstract
Background
Off-targeted
distribution
of
chemotherapeutic
drugs
causes
severe
side
effects,
further
leading
to
poor
prognosis
and
patient
compliance.
Ligand/receptor-mediated
targeted
drug
delivery
can
improve
accumulation
in
the
tumor
but
it
always
attenuated
by
protein
corona
barriers.
Results
To
address
these
problems,
a
radically
different
strategy
is
proposed
that
leave
off-targeted
inactive
activate
tumor-distributed
for
cancer-targeting
therapy
microenvironment-independent
manner.
The
feasibility
effectiveness
this
demonstrated
developing
an
ultrasound
(US)-activated
prodrug-loaded
liposome
(CPBSN38L)
comprising
sonosensitizer
chlorin
e6
(Ce6)-modified
lipids
prodrug
pinacol
boronic
ester-conjugated
SN38
(PBSN38).
Once
CPBSN38L
accumulated
internalized
into
cancer
cells,
under
US
irradiation,
Ce6
rapidly
induces
extensive
production
intracellular
reactive
oxygen
species
(ROS),
thereby
initiating
cascade
amplified
ROS-responsive
activation
PBSN38
release
active
inducing
cell
apoptosis.
If
some
injected
distributed
normal
tissues,
exerts
no
pharmacological
activity
on
cells.
exhibited
strong
anticancer
multiple
murine
models
colon
adenocarcinoma
hepatocellular
carcinoma
with
chemotherapy-induced
compared
standard
first-line
irinotecan
topotecan.
Conclusions
This
study
established
side-effect-evitable,
universal,
feasible
therapy.
Graphical
